Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 44, Pages 11756-11761Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403835
Keywords
fluorescence; gold; molecular imaging; nanoparticles; SERS
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Funding
- Damon Runyon Cancer Research Foundation [DRR-29-14]
- Dana Foundation Brain and ImmunoImaging
- Neuroscience Scholar Award
- Bayer HealthCare Pharmaceuticals/RSNA Research Scholar
- MSKCC Molecular Imaging and Nanotechnology Center Grant
- MSKCC Technology Development Grant
- MSKCC Brain Tumor Center Grant
- Society of MSKCC Research Grant
- Geoffrey Beene Cancer Research Center at MSKCC Grant Award
- Shared Resources Award
- Cancer Center Core Grant (CCSG) [P30 CA008748]
- [NIH R01EB017748]
- [K08CA16396]
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SERS nanoprobes for in vivo biomedical applications require high quantum yield, long circulation times, and maximum colloidal stability. Traditional synthetic routes require high metal-dye affinities and are challenged by unfavorable electrostatic interactions and limited scalability. We report the synthesis of a new near-IR active poly(N-(2-hydroxypropyl) methacrylamide) (pHPMA). The integration of various SERS reporters into a biocompatible polymeric surface coating allows for controlled dye incorporation, high colloidal stability, and optimized in vivo circulation times. This technique allows the synthesis of very small (<20 nm) SERS probes, which is crucial for the design of excretable and thus highly translatable imaging agents. Depending on their size, the schizophotonic nanoparticles can emit both SERS and fluorescence. We demonstrate the capability of this all-in-one gold surface coating and SERS reporter for multiplexed lymph-node imaging.
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