Industrial Applications of the Diels-Alder Reaction

One Hundred Years of Vitamins-A Success Story of the Natural Sciences

(2012) Manfred Eggersdorfer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic approaches to the 2010 new drugs

(2012) Kevin K.-C. Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics

(2012) Rohit Singh et al.   CHEMICAL REVIEWS

Scalable Synthesis of Enantiomerically Pure Bicyclo[2.2.2]octadiene Ligands

(2012) Stefan Abele et al.   JOURNAL OF ORGANIC CHEMISTRY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Isoindolone Formation via Intramolecular Diels–Alder Reaction

(2012) Matthew Ball et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction

(2012) Bruce G. Anderson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Safety Assessment of Diels–Alder Reactions with Highly Reactive Acrylic Monomers

(2012) Stefan Abele et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Nitrosocarbonyl Hetero-Diels-Alder Reaction as a Useful Tool for Organic Syntheses

(2011) Brian S. Bodnar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

(2011) Javier Magano et al.   CHEMICAL REVIEWS

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxazole as an Electron-Deficient Diene in the Diels–Alder Reaction

(2011) Galdina Vanessa Suárez-Moreno et al.   ORGANIC LETTERS

Design and Scale-Up of Diels–Alder Reactions for the Practical Synthesis of 5-Phenylbicyclo[2.2.2]oct-5-en-2-one

(2011) Jacques-Alexis Funel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

High-Temperature Diels–Alder Reactions: Transfer from Batch to Continuous Mode

(2011) Stefan Abele et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Design and Scale-Up of a Practical Enantioselective Route to 5-Phenylbicyclo[2.2.2]oct-5-en-2-one

(2011) Stefan Abele et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent synthetic approaches to oseltamivir phosphate (Tamiflu™) for the treatment of influenza

(2011) Javier Magano   TETRAHEDRON

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context

(2010) Hans-Jürgen Federsel   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic approaches to the 2009 new drugs

(2010) Kevin K.-C. Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Synthetic Approaches to the 2008 New Drugs

(2010) Kevin K.-C. Liu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Practical Synthesis of the PDE4 Inhibitor, KW-4490

(2010) Arata Yanagisawa et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale

(2010) David H. Brown Ripin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantioselective synthesis of (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid

(2010) Beat Wirz et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Synthesis of (−)-β-Santalol by a Copper-Catalyzed Enynol Cyclization-Fragmentation Reaction

(2009) Charles Fehr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

(2009) Frank Ruebsam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza

(2009) Javier Magano   CHEMICAL REVIEWS

Recent applications of intramolecular Diels–Alder reactions to natural product synthesis

(2009) Martin Juhl et al.   CHEMICAL SOCIETY REVIEWS

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

(2009) Linda E. Keown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists

(2009) Jinlong Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[(2R)-2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical Candidate

(2009) Atsushi Satoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Large-Scale Preparation of (+)-p-Menth-2-ene-1,8-diol, a Key Intermediate in the Synthesis of Δ-9-Tetrahydrocannabinol

(2009) John E. Cabaj et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Endo-selective Diels–Alder reaction of methacrylonitrile: application to the synthesis of Georgywood

(2009) Andras Borosy et al.   TETRAHEDRON

Asymmetric Diels-Alder Reactions of α,β-Unsaturated Aldehydes Catalyzed by a Diarylprolinol Silyl Ether Salt in the Presence of Water

(2008) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A survey of the syntheses of active pharmaceutical ingredients for antiretroviral drug combinations critical to access in emerging nations

(2008) Eloan dos Santos Pinheiro et al.   ANTIVIRAL RESEARCH

Alkyne chemistry in crop protection

(2008) Clemens Lamberth   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

(2008) Jöel Robichaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biophysical Studies, and Antiproliferative Activity of Platinum(II) Complexes Having 1,2-Bis(aminomethyl)carbobicyclic Ligands

(2008) Jordi de Mier-Vinué et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity

(2008) Samuel Chackalamannil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents

(2008) John B. Matson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Approaches to the 2007 New Drugs

(2008) Kevin Liu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity of Drugs

(2008) Vasulinga T. Ravikumar et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay

(2007) I.P. Lee et al.   FOOD AND CHEMICAL TOXICOLOGY