Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation

A Bioreducible Polymer for Efficient Delivery of Fas-Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis

(2012) Min Suk Shim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Hybrid Nanoconjugates for Efficient In Vivo Delivery of Immunomodulating Oligonucleotides and Enhanced Antitumor Immunity

(2012) Ji Hyun Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor-Homing Poly-siRNA/Glycol Chitosan Self-Cross-Linked Nanoparticles for Systemic siRNA Delivery in Cancer Treatment

(2012) So Jin Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation

(2012) Keita Un et al.   HEPATOLOGY

Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models

(2012) Yihua Loo et al.   JOURNAL OF CONTROLLED RELEASE

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Reactive and Bioactive Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery

(2011) Nathan P. Gabrielson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo

(2011) Patric Lundberg et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Ionic polypeptides with unusual helical stability

(2011) Hua Lu et al.   Nature Communications

Multiplexed supramolecular self-assembly for non-viral gene delivery

(2010) Nathan P. Gabrielson et al.   BIOMATERIALS

Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon

(2010) Hamed Laroui et al.   BIOMATERIALS

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

(2010) Christina Kriegel et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

(2010) Sang-Soo Kim et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles

(2009) Hao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

(2009) Lichen Yin et al.   BIOMATERIALS

Golimumab

(2009) C. Dulsat et al.   DRUGS OF THE FUTURE

Transport of chitosan–DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes

(2009) Irina Kadiyala et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination

(2009) Virginie Fievez et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Solid polymeric microparticles enhance the delivery of siRNA to macrophages in vivo

(2009) S. Lee et al.   NUCLEIC ACIDS RESEARCH

Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs

(2008) Yu-Hsin Lin et al.   JOURNAL OF CONTROLLED RELEASE

Gene transfer to hemophilia A mice via oral delivery of FVIII–chitosan nanoparticles

(2008) Katherine Bowman et al.   JOURNAL OF CONTROLLED RELEASE

Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-α

(2008) Lei Dong et al.   JOURNAL OF CONTROLLED RELEASE

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY