Review
Biochemistry & Molecular Biology
MacLean C. Sellars, Catherine J. Wu, Edward F. Fritsch
Summary: This article reviews the immunologic concepts of cancer vaccines and highlights the challenges they face. Recent technological advances provide new opportunities for studying cancer vaccines, such as neoantigen prediction and genetically engineered models.
Article
Polymer Science
Yoichi Okayama, Taejun Eom, Michael Czuczola, Allison Abdilla, Jacob R. Blankenship, Kaitlin R. Albanese, Javier Read de Alaniz, Christopher M. Bates, Craig J. Hawker
Summary: The synthetic utility of heterotelechelic polydimethylsiloxane (PDMS) derivatives was enhanced by using a specifically designed silyl hydride (Si-H)-based initiator for anionic ring-opening polymerization (AROP) of hexamethylcyclotrisiloxane (D-3) monomers. The resulting PDMS polymers had high chain-end fidelity and heterotelechelic functionality. In situ termination of the propagating chain end with different chlorosilanes and functionalized alkenes further increased the diversity of the PDMS derivatives. The living nature of the polymerization allowed for the synthesis of narrow-dispersity polymers with a wide range of molar masses. Additionally, the feasibility of synthesizing supersoft bottlebrush networks using the PDMS macromonomers was demonstrated.
Editorial Material
Multidisciplinary Sciences
Ewen Callaway
Summary: New technologies may offer stronger or wider immunity, but they will face competition for market share.
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bosse, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren, Jon Cuccui
Summary: We have developed a novel biotechnological platform called MAGIC, which overcomes the limitations of current conjugate vaccine design methods and improves the yield of glycoconjugates. We have also improved MAGIC to allow rapid installation of glycoengineering components, eliminate the use of antibiotics, and reduce reliance on protein induction agents. Additionally, we demonstrate the versatility of the MAGIC platform in performing glycoengineering in genetically less tractable bacterial species. The MAGIC system promises to be a rapid, robust, and versatile method for developing vaccines against serious bacterial pathogens.
MICROBIAL CELL FACTORIES
(2023)
Review
Biochemistry & Molecular Biology
Mohammed Yusuf Zanna, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Suri Arshad, Abdul Razak Mariatulqabtiah, Saulol Hamid Nur-Fazila, Md Isa Nur Mahiza
Summary: Dendritic cells are crucial antigen-presenting cells in the immune system, playing a significant role in activating T cells and maintaining immune balance. Their distribution and dynamic perspectives in various animal species, as well as their roles in diseases, have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chengcheng Liu, Wenwen Qi, Zhenxiao Teng, Runtong Xu, Yue Xi, Yiming Qin, Fenglei Xu, Lei Shi, Miaoqing Zhao, Ming Xia
Summary: This study suggests that NGR-PM-SHI could be a novel strategy for targeted treatment of allergic rhinitis through the NF-kappa B pathway by targeting PARP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Nathifa A. Moyo, Dave Westcott, Rachel Simmonds, Falko Steinbach
Summary: This study investigates the interaction between EAV and host immune cells, specifically dendritic cells (DC), using an optimized eqMoDC system. The results show that EAV is able to replicate in monocytes and mature MoDC, and has an effect on cell morphology, phenotype, and function. EAV evades host anti-viral immunity through inhibition of antigen presentation early after infection and by killing infected DC during replication.
Article
Immunology
Sara Sadat Aghamiri, Bhanwar Lal Puniya, Rada Amin, Tomas Helikar
Summary: Dendritic cells (DCs) are professional antigen-presenting cells that play a critical role in shaping immunity. Researchers have developed a logical and predictive model of DC function, integrating the heterogeneity of DCs population, APC function, and cell-cell interaction, to study cell dynamics and disease environments, providing a platform for vaccine design, drug discovery, and immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
E. Hancox, M. J. Derry, M. J. Greenall, S. Huband, L. Al-Shok, J. S. Town, P. D. Topham, D. M. Haddleton
Summary: Fluoro-poly(acrylic acid) heterotelechelic homopolymers have been synthesized to mimic the ultrafine domains of high chi-low N diblock copolymers. The thermodynamically stable nanomorphologies of lamellar or hexagonally packed cylinders were obtained by heating/cooling ramps. These telechelic homopolymers mimic high chi-ultralow N diblock copolymers and enable reproducible targeting of nanomorphologies with incredibly small, tunable domain size.
Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Alessio Alesci, Gioele Capillo, Angelo Fumia, Emmanuele Messina, Marco Albano, Marialuisa Aragona, Patrizia Lo Cascio, Nunziacarla Spano, Simona Pergolizzi, Eugenia Rita Lauriano
Summary: This study aimed to characterize intestinal dendritic cells (DCs) from myxines to teleosts using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II. The findings reveal the presence of DCs and DC-like cells phylogenetically from myxines to teleosts, providing new insights into the evolution of the immune system and the role of sentinel cells in body defense.
Article
Immunology
Durga Reddi, Lydia Durant, David Bernardo, Alistair Noble, Nicholas R. English, Philip Hendy, Graeme C. Clark, Joann L. Prior, Ethel Diane Williamson, Stella C. Knight
Summary: The study demonstrated the in vitro priming of naïve human T cells against heat-killed B. pseudomallei by co-culturing with syngeneic, pulsed dendritic cells. Myeloid DCs showed a major response to B. pseudomallei, contributing significantly to the expression of migration marker CCR7 and secretion of proinflammatory cytokines TNF alpha and IL1 beta. The study suggests that this approach could be used to screen for human cellular response to candidate vaccines and enhance cell-mediated immunity against intracellular pathogens.
Review
Pharmacology & Pharmacy
Hannah M. VanBenschoten, Kim A. Woodrow
Summary: Recent estimates show that one in two sexually active individuals will acquire a sexually transmitted infection by age 25, highlighting the importance of vaccination against STIs. Vaginal immunization is a promising strategy to combat transmission via the vaginal mucosa by overcoming immune tolerance and establishing tissue resident memory immune cells. Research is focusing on exploring the potential of vaginal vaccine studies and the role of mucosal adjuvants and delivery systems in enhancing immunity.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Chemistry, Medicinal
Amy E. Nielsen, Joseph D. Hantho, Rock J. Mancini
FUTURE MEDICINAL CHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Keun Ah Ryu, Bethany McGonnigal, Troy Moore, Tawnya Kargupta, Rock J. Mancini, Aaron P. Esser-Kahn
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Anthony J. Burt, Joseph D. Hantho, Amy E. Nielsen, Rock J. Mancini
Meeting Abstract
Oncology
Amy E. Nielsen, Rock J. Mancini
Article
Nanoscience & Nanotechnology
Can Yang Zhang, Wenjing Lin, Jin Gao, Xutong Shi, Maryam Davaritouchaee, Amy E. Nielsen, Rock J. Mancin, Zhenjia Wang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Agricultural Engineering
Maryam Davaritouchaee, William C. Hiscox, Jose Martinez-Fernandez, Xiao Fu, Rock J. Mancini, Shulin Chen
INDUSTRIAL CROPS AND PRODUCTS
(2019)
Article
Chemistry, Multidisciplinary
Austin T. Ryan, Anunay J. Pulukuri, Maryam Davaritouchaee, Armina Abbasi, Aaron T. Hendricksen, Larissa K. Opp, Anthony J. Burt, Amy E. Nielsen, Rock J. Mancini
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Chemistry, Medicinal
Anthony J. Burt, Parvaneh Ahmadvand, Larissa K. Opp, Austin T. Ryan, ChulHee Kang, Rock J. Mancini
Article
Chemistry, Medicinal
Anunay J. Pulukuri, Anthony J. Burt, Larissa K. Opp, Colin M. McDowell, Maryam Davaritouchaee, Amy E. Nielsen, Rock J. Mancini
Summary: Studies show that in MDR cancers, P-gp mediated drug efflux can impact the efficacy of TLR 7/8 agonists, with Imiquimod potentially being the best substrate for P-gp.
Article
Engineering, Chemical
Maryam Davaritouchaee, Shulin Chen, Rock J. Mancini
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Meeting Abstract
Immunology
Rock Mancini, Austin Ryan, Anunay Pulukri, Maryam Davaritouchaee, Armina Abbasi, Aaron Hendricksen, Larissa Opp, Anthony Burt, Amy Nielsen
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Rock Mancini, Maryam Davaritouchaee, Aaron Hendricksen, Amy Nielsen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Maryam Davaritouchaee, William C. Hiscox, Evan Terrell, Rock J. Mancini, Shulin Chen
Meeting Abstract
Chemistry, Multidisciplinary
Rock Mancini, Amy Nielsen, Joe Hantho, Anthony Burt
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Meeting Abstract
Chemistry, Multidisciplinary
Joe Hantho, Rock Mancini, Amy Nielsen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
