Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin

A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis

(2012) Luz E. Núñez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway

(2012) Nidhi Tibrewal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigating Mithramycin Deoxysugar Biosynthesis: Enzymatic Total Synthesis of TDP-D-Olivose

(2011) Guojun Wang et al.   CHEMBIOCHEM

Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

(2011) Xiuling Chi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

(2011) Richard W. Gantt et al.   NATURAL PRODUCT REPORTS

Characterization of JadH as an FAD- and NAD(P)H-Dependent Bifunctional Hydroxylase/Dehydrase in Jadomycin Biosynthesis

(2010) Yihua Chen  et al.   CHEMBIOCHEM

Real-time NMR monitoring of intermediates and labile products of the bifunctional enzyme UDP-apiose/UDP-xylose synthase

(2009) Paul Guyett et al.   CARBOHYDRATE RESEARCH

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

(2008) María Pérez et al.   CHEMBIOCHEM

Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

(2008) Irfan Baig et al.   JOURNAL OF NATURAL PRODUCTS

Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

(2008) B. D. Ames et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA