Article
Food Science & Technology
Phung Diep Huy Vu, Akkaratch Rodklongtan, Pakamon Chitprasert
Summary: The study found that the encapsulant weight ratio of whey protein isolate-lignin complex significantly affects the survival rate of spray-dried probiotics, with the 9:1 ratio offering the best protection. Lignin improves the survival of probiotics by enhancing the structure and antioxidant properties of WPI.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Alireza Behnamifar, Shaban Rahimi, Mohammad Amir Karimi Torshizi, Mohsen Sharafi, J. L. Grimes
Summary: This study investigated the effects of alpha-lipoic acid supplementation on the semen quality and fertility parameters of aging breeder roosters, finding that appropriate levels of ALA can improve sperm quality, while higher doses do not result in further improvement.
Review
Biochemistry & Molecular Biology
Onchuma Mueangson, Aongart Mahittikorn, Nsoh Godwin Anabire, Wanida Mala, Manas Kotepui
Summary: This study examined the relationship between malondialdehyde (MDA) concentrations and Plasmodium infections. The results showed that MDA concentrations were significantly elevated in patients with malaria compared to uninfected controls, indicating an increase in oxidative stress and lipid peroxidation. MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria.
Article
Plant Sciences
Zhen Zhang, Shasha Yang, Xia Lin, You Huang, Xinyi Wei, Jinwei Zhou, Rui Li, Bin Deng, Chaomei Fu
Summary: The study investigated the essence of Spleen-Yang deficiency (SYD) through metabolomics and revealed the anti-SYD action mechanisms of Fuzi Lizhong pill (FLZP). Results showed that FLZP regulated biomarkers related to SYD, alleviating diarrhea and gastrointestinal motility disorder, and exhibiting anti-peroxidation, anti-inflammatory, and immune regulation effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Adam Wronski, Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: Psoriasis is an immune-mediated skin disease characterized by excessive proliferation and keratinization of epidermal cells, resulting in psoriatic lesions. It is caused by pathological interaction with immune cells, particularly lymphocytes, which are responsible for systemic inflammation. Oxidative stress and lipid peroxidation products exacerbate the inflammation. This review focuses on the changes in lipid peroxidation products and their influence on protein structures during psoriasis development, emphasizing the importance of understanding their role in the design of preventive cosmetics or anti-psoriasis therapies.
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Article
Food Science & Technology
Wenjie Wang, Zhiwen Zhang, Xiaoying Liu, Xiaoji Cao, Lianzhu Wang, Yuting Ding, Xuxia Zhou
Summary: Malondialdehyde (MDA) is an important indicator of lipid oxidation in food. However, the reaction between MDA and nitrite in salted lean pork leads to an underestimation of lipid oxidation in traditional assays. This study successfully improved the accuracy of MDA quantification by using GC-MS analysis with deuterium substituted MDA as an internal standard and applying perfluorophenylhydrazine as a derivative reagent.
Article
Multidisciplinary Sciences
Hailah M. Almohaimeed, Hanan Waly, Nasser S. Abou Khalil, Khaled M. A. Hassanein, Basal Sulaiman M. Alkhudhairy, Elham A. Abd-Allah
Summary: This study investigated the neuroprotective effects of gum Arabic nanoemulsion (GANE) in bromobenzene (BB)-induced neurological lesions. The results demonstrated that GANE can reverse redox imbalance and apoptotic pathways caused by BB, and alleviate neuropathological damage.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Afoon Talaie, Hanieh Jafary, Fardin Faraji, Ali Akbar Malekirad
Summary: This study found that migraine patients had lower serum selenium levels and higher MDA levels, while TAC levels were not significantly different compared to healthy individuals. The lower selenium and higher MDA levels were significantly associated with migraine, indicating that oxidative stress may play an important role in the pathogenesis of migraine.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Plant Sciences
Roberto O. Ybanez-Julca, Javier Palacios, Daniel Asuncion-Alvarez, Ivan Quispe-Diaz, Chukwuemeka R. Nwokocha, Ricardo Diego Duarte Galhardo de Albuquerque
Summary: Red maca, a plant cultivated in the Andes since the time of the Incas, has numerous therapeutic properties. This study used UHPLC-ESI-MS/MS to identify its phytochemical composition and evaluated its effects on acrylamide-induced oxidative stress. The results showed that oral administration of the aqueous extract of red maca prevented an increase in malondialdehyde levels, reduced liver enzyme levels, and ameliorated oxidative stress. Additionally, 25 secondary metabolites were identified in the extract, which may contribute to its antioxidant protective role.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Vadim Z. Z. Lankin, Alla K. K. Tikhaze, Arthur M. M. Melkumyants
Summary: This mini review discusses the role of malondialdehyde (MDA) in the molecular mechanisms of primary atherosclerotic vascular wall lesions. It highlights the important role of chemically modified LDL particles containing MDA in atherogenesis, rather than oxidized LDL. The review also presents experimental evidence of MDA damaging the endothelial glycocalyx, impairing the endothelium's ability to regulate arterial tone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Esmat Atefepour, Mohammad Saadatian, Moazzam Hassanpour Asil, Babak Rabiei
Summary: The use of silver nanoparticles and 8-hydroxyquinoline citrate as pulse treatment, combined with sucrose, significantly increased the vase life and quality of cut Gerbera flowers.
SCIENTIA HORTICULTURAE
(2021)
Article
Biochemistry & Molecular Biology
Azza A. A. Attia, Jehan M. M. Sorour, Neama A. A. Mohamed, Tagreed T. T. Mansour, Rasha A. A. Al-Eisa, Nahla S. S. El-Shenawy
Summary: This study aimed to investigate the protective role of vitamin E in improving cardiotoxicity induced by cyclophosphamide in rats. The results showed that vitamin E could attenuate the elevation of cardiac markers, increase in lipid profiles, reduction in antioxidant enzyme activities, and increase in lipid peroxidation. In addition, vitamin E was found to improve the histopathological alterations caused by cyclophosphamide.
Article
Public, Environmental & Occupational Health
Marek Zmyslony, Pawel Bienkowski, Alicja Bortkiewicz, Jolanta Karpowicz, Jaroslaw Kieliszek, Piotr Politanski, Konrad Rydzynski
Article
Energy & Fuels
Jaroslaw Kieliszek, Joanna Wyszkowska, Jaromir Sobiech, Robert Puta
Review
Biochemistry & Molecular Biology
Edyta Janik, Marcin Niemcewicz, Michal Ceremuga, Lukasz Krzowski, Joanna Saluk-Bijak, Michal Bijak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Microbiology
Edyta Janik, Maciej Bartos, Marcin Niemcewicz, Leslaw Gorniak, Michal Bijak
Summary: The new coronavirus, officially designated as SARS-CoV-2, began to spread globally in late 2019, leading to a pandemic declaration by the World Health Organization in March 2020. Effective preventive measures, such as social distancing, mask usage, good hygiene practice, and additional protection for healthcare professionals, are crucial in controlling virus transmission.
Review
Biochemistry & Molecular Biology
Angela Dziedzic, Joanna Saluk-Bijak, Elzbieta Miller, Marcin Niemcewicz, Michal Bijak
Summary: The study found that infection with the novel coronavirus may have serious consequences for patients with multiple sclerosis, potentially leading to neurodegenerative diseases such as demyelination. Infection with the novel coronavirus can trigger cytokine storm syndrome, increasing the risk of developing acute cerebrovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Edyta Janik, Marcin Niemcewicz, Marcin Podogrocki, Joanna Saluk-Bijak, Michal Bijak
Summary: COVID-19 is a respiratory disease caused by SARS-CoV-2, for which finding effective drugs remains a urgent target for the global scientific community. The pathogenesis is mainly related to virus replication and excessive immune/inflammatory response. Treatment options include antiviral and immunomodulatory/anti-inflammatory agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Edyta Janik, Marcin Niemcewicz, Marcin Podogrocki, Michal Ceremuga, Leslaw Gorniak, Maksymilian Stela, Michal Bijak
Summary: Mycotoxins are a wide range of fungal metabolites that contaminate various agricultural commodities and pose a risk to public health. Different methods, such as chromatographic and immunochemical techniques, as well as novel approaches like biosensors, have been developed for the detection and identification of mycotoxins in food products.
Review
Microbiology
Edyta Janik, Marcin Niemcewicz, Marcin Podogrocki, Ireneusz Majsterek, Michal Bijak
Summary: Since the discovery of the SARS-CoV-2 responsible for COVID-19 in December 2019, the virus has continually mutated, with three variants of concern and four variants of interest being distinguished in recent months and requiring close monitoring.
Article
Biotechnology & Applied Microbiology
Ewelina Maculewicz, Bozena Antkowiak, Oktawiusz Antkowiak, Anna Borecka, Andrzej Mastalerz, Agata Leonska-Duniec, Kinga Huminska-Lisowska, Monika Michalowska-Sawczyn, Aleksandra Garbacz, Katarzyna Lorenz, Ewa Szarska, Lukasz Dziuda, Anna Cywinska, Pawel Cieszczyk
Summary: This study further confirms the involvement of IL-1 family genes in the genetic background of obesity. While certain single-nucleotide polymorphisms (SNPs) within the IL1A, IL1B, and IL1RN genes were not associated with BMI and fat % in the tested population, the SNP-SNP interaction of IL1B x IL1RN was associated with both BMI and fat %.
Review
Biochemistry & Molecular Biology
Edyta Janik, Marcin Niemcewicz, Marcin Podogrocki, Michal Ceremuga, Maksymilian Stela, Michal Bijak
Summary: T-2 toxin, the most toxic fungal secondary metabolite produced by different Fusarium species, is commonly found in contaminated cereal-based food and feed made from wheat, barley, rye, oats, and maize. Various decontamination techniques have been developed to mitigate the concentration of T-2 toxin in agricultural commodities, but complete degradation of this toxin is believed to be impossible.
Article
Genetics & Heredity
Ewelina Maculewicz, Magdalena Dzitkowska-Zabielska, Bozena Antkowiak, Oktawiusz Antkowiak, Andrzej Mastalerz, Aleksandra Garbacz, Myosotis Massidda, Aleksandra Bojarczuk, Lukasz Dziuda, Pawel Cieszczyk
Summary: This study investigated the relationship between SNPs of IL10 and IL10RB genes and the risk of obesity in young men. The results showed a significant association between the interaction of IL10 (rs1518110) and IL10RB (rs2834167) and Fat% value exceeding 20.
Article
Genetics & Heredity
Ewelina Maculewicz, Bozena Antkowiak, Oktawiusz Antkowiak, Andrzej Mastalerz, Agnieszka Bialek, Anna Cywinska, Anna Borecka, Kinga Huminska-Lisowska, Aleksandra Garbacz, Katarzyna Lorenz, Ewa Szarska, Monika Michalowska-Sawczyn, Lukasz Dziuda, Pawel Cieszczyk
Summary: In this study, no relationship was found between obesity parameters and IL-6 gene polymorphisms in a homogeneous group of young, male military professionals. The results suggest that even with a genetic predisposition, the impact on individuals with mild obesity can be reduced by changes in lifestyle.
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Magdalena Wieckowska, Monika Szyposzynska, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Michal Bijak
Summary: T-2 toxin, produced by various Fusarium species, can infect crops such as wheat, barley, and corn. This in vitro study reveals that T-2 toxin induces necrosis in human skin fibroblast cells, providing new insights into its toxic mechanism on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Edyta Janik, Michal Ceremuga, Marcin Niemcewicz, Michal Bijak
MEDICINA-LITHUANIA
(2020)
Review
Biochemistry & Molecular Biology
Edyta Janik, Marcin Niemcewicz, Michal Ceremuga, Maksymilian Stela, Joanna Saluk-Bijak, Adrian Siadkowski, Michal Bijak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
