Article
Polymer Science
Manuel Nunez-Martinez, Sandra Arias, Julian Bergueiro, Emilio Quinoa, Ricardo Riguera, Felix Freire
Summary: A novel method was used to prepare PPA-Au nanocomposites by avoiding interactions between the polymer and gold ions, and using strong thiol-Au connections to restrict conformational changes in the polymer. This approach successfully achieved the ordered alignment and stability of nanoparticles along the polymer chain.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Kinga Zelechowska-Matysiak, Evangelia-Alexandra Salvanou, Penelope Bouziotis, Tadeusz Budlewski, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
Summary: In this article, we introduce a multimodal radiobioconjugate composed of doxorubicin, Au-198, and trastuzumab for targeted therapy of HER2+ cancers. The radiobioconjugate showed high affinity to HER2 receptors and induced cell cycle arrest and apoptosis in vitro. In spheroid models, it demonstrated dose-dependent additive and synergistic effects. Biodistribution and therapeutic efficacy studies in tumor-bearing mice exhibited promising results.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Fozia Iram, Abida Yasmeen, Shazma Massey, Mohammad S. Iqbal, Sumreen Asim, Misbah Irshad, Hina Zahid, Athar Y. Khan, Syed G. T. Kazimi
Summary: Gold and silver nanoparticles were successfully synthesized using arabinoglucan from Lallemantia royleana seeds, showing high stability without the need for additional reducing or stabilizing agents. The nanoparticles exhibited excellent optical properties, with potential applications in surface-enhanced Raman spectroscopy. Silver nanoparticles demonstrated dose-dependent biological activities, including cytotoxicity against brine shrimps, HeLa cell lines, and tumors caused by A. tumefaciens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Ga-Hyun Kim, Minji Kim, Jerome K. Hyun, So-Jung Park
Summary: Here, we report the directional stimuli-responsive self-assembly of gold nanoparticles (AuNPs) coated with a thermoresponsive block copolymer (BCP), poly(ethylene glycol)-b-poly(N-isopropylacrylamide) (PEG-b-PNIPAM), and charged small molecules. The temperature-induced self-assembly resulted in one-dimensional (1D) or two-dimensional (2D) structures in salt solutions, with the morphology dependent on the ionic strength of the medium. Salt-free self-assembly was achieved by modulating the surface charge using positively charged small molecules, with the assembly type determined by the ratio between the small molecule and PEG-b-PNIPAM. This study demonstrates an effective approach for on-demand directional self-assembly of nanoparticles (NPs) with controlled morphology, interparticle distance, and optical properties.
Article
Materials Science, Multidisciplinary
Huan Wang, Bokai Liao, Yuebin Xi, Yunhui Feng, Huixiang Wu
Summary: In this study, a composite material of titanium dioxide (TiO2), gold nanoparticles (AuNPs), and polystyrene (PS) (TiO2/Au/PS) with excellent fluorescent and photoelectric properties was fabricated. The TiO2/Au/PS composite exhibited much stronger fluorescent emission compared to its single component counterparts and any pairwise combination. Furthermore, it also showed a stronger photogenerated current compared to TiO2/PS due to the synergistic enhancement effect.
Article
Chemistry, Multidisciplinary
Manlin Zhang, Michael Lindner-D'Addario, Mahdi Roohnikan, Violeta Toader, Robert Bruce Lennox, Linda Reven
Summary: This study investigates the dispersion of ethylene oxide oligomers and polymers, both free and tethered to gold nanoparticles, in blue phase liquid crystals (BPLC). The results show that the functionalization and molecular weight of the gold nanoparticles can affect the stability and temperature range of the blue phase.
Article
Chemistry, Analytical
Shimayali Kaushal, Anil Kumar, Sanjeev Soni, Nitin Kumar Singhal
Summary: A hybrid antibody biosensor based on graphene oxide-coated gold nanoparticles was developed for fast, specific, and high sensitivity foodborne bacterial detection. The biosensor showed colorimetric and spectrophotometric changes up to 10(3) and 10(2) CFU, respectively, when incubated with Escherichia coli and Salmonella typhimurium for 5 minutes. Immobilized antibodies on the hybrid nanoparticle biosensor were specific to bacteria and exhibited specific photoablation of bacteria upon infrared exposure. This antibody-functionalized biosensor allowed for rapid optical detection and extermination of foodborne bacteria.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Joanna Korpanty, Lucas R. Parent, Nathan C. Gianneschi
Summary: In the study, the radiolytic environment experienced by a polymer in water during LCTEM was examined, showing the significant mitigation effect of IPA on polymer damage and the enhancement effect of GNPs. The combination of experiments and simulations provided a generalizable strategy for assessing radiolysis mitigation or enhancement. The study highlights the caution needed for LCTEM experiments involving inorganic nanoparticles and suggests an increased use of scavengers for various LCTEM studies.
Article
Chemistry, Multidisciplinary
Milad Torabfam, Mona Nejatpour, Tuce Fidan, Hasan Kurt, Meral Yuce, Mustafa Kemal Bayazit
Summary: The challenge of continuously manufacturing nanocomposites with a narrow size distribution has been overcome using a microwave-powered fluidic system (MWFS). By adjusting the microwave power, flow rate, and concentration of reagents, the study successfully produced nylon-6 nanocomposites with evenly distributed silver nanoparticles. The size of the nanoparticles can be controlled by the polymer concentration and microwave power.
Article
Chemistry, Multidisciplinary
Parinaz Fathi, Ayman Roslend, Kritika Mehta, Parikshit Moitra, Kai Zhang, Dipanjan Pan
Summary: Increasing the fluorescence quantum yield of fluorophores is a key interest in biomedical imaging, with biliverdin showing promise in response to UV irradiation without photobleaching. Chelating biliverdin with metals further enhances its fluorescence behavior, suggesting UV irradiation and metal chelation can be utilized to tailor the fluorescence behavior of imaging probes.
Article
Nanoscience & Nanotechnology
Praveen, Shuko Suzuki, Idriss Blakey, Peta L. Clode, Martin Saunders, Matthew B. Myers, Traian Chirila, Murray Baker
Summary: Poly(2-hydroxyethyl methacrylate) hydrogels doped with gold nanoparticles (Au-PHEMA) were prepared through photochemically and thermally induced phase separation polymerization. The resulting hydrogels exhibited a network morphology suitable for surface-enhanced Raman scattering applications.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Kinga Zelechowska-Matysiak, Kamil Wawrowicz, Mateusz Wierzbicki, Tadeusz Budlewski, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
Summary: In this study, a novel bioconjugate (DOX-AuNPs-Tmab) consisting of gold nanoparticles (AuNPs) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), was synthesized. The bioconjugate exhibited specific binding to HER2 receptors and demonstrated high specificity of binding and internalization capabilities to HER2-positive cancer cells. Cytotoxicity experiments showed that DOX-AuNPs-Tmab significantly reduced cancer cell metabolic activity and surface area of spheroids, inducing cell cycle arrest and late apoptosis. These findings suggest that DOX-AuNPs-Tmab has great potential for targeted therapy of HER2-positive tumors.
Review
Polymer Science
Shuaikai Ren, Mengjie Wang, Chunxin Wang, Yan Wang, Changjiao Sun, Zhanghua Zeng, Haixin Cui, Xiang Zhao
Summary: This review highlighted the importance of non-viral vectors in gene therapy and drug delivery, due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production. The review summarized various non-viral vectors including polymers, liposomes, gold nanoparticles, mesoporous silica nanoparticles and carbon nanotubes, discussing their physicochemical characteristics, synthesis methods, functional modifications, and research applications, as well as future research directions.
Review
Pharmacology & Pharmacy
Xiaohan Ma, Jonathan C. Knowles, Alessandro Poma
Summary: Molecular imprinting technology has made significant advancements in the design and production of MIP nanoparticles (MIP NPs) as antibody substitutes. However, its overall sustainability and biodegradability have been questioned. This review aims to examine the production and purification strategies of MIP NPs from a sustainability and waste management perspective.
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Chemistry, Multidisciplinary
Liliang Huang, Haixin Lin, Cindy Y. Zheng, Edward J. Kluender, Rustin Golnabi, Bo Shen, Chad A. Mirkin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Physical
Seung-Hoon Lee, Taegon Oh, Jehyeok Ryu, Chad A. Mirkin, Jae-Won Jang
CHEMISTRY OF MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Peng-Cheng Chen, Yuan Liu, Jingshan S. Du, Brian Meckes, Vinayak P. Dravid, Chad A. Mirkin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
C. Adrian Figg, Peter H. Winegar, Oliver G. Hayes, Chad A. Mirkin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Multidisciplinary Sciences
Shunzhi Wang, Sarah S. Park, Cassandra T. Buru, Haixin Lin, Peng-Cheng Chen, Eric W. Roth, Omar K. Farha, Chad A. Mirkin
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Caroline D. Kusmierz, Katherine E. Bujold, Cassandra E. Callmann, Chad A. Mirkin
ACS CENTRAL SCIENCE
(2020)
Article
Multidisciplinary Sciences
Jingshan S. Du, Donghoon Shin, Teodor K. Stanev, Chiara Musumeci, Zhuang Xie, Ziyin Huang, Minliang Lai, Lin Sun, Wenjie Zhou, Nathaniel P. Stern, Vinayak P. Dravid, Chad A. Mirkin
Article
Chemistry, Multidisciplinary
Zachary J. Urbach, Sarah S. Park, Steven L. Weigand, James E. Rix, Byeongdu Lee, Chad A. Mirkin
Summary: The study demonstrates that in a magnetic field, cubic Fe3O4 nanoparticles functionalized with DNA can exhibit unexpected crystallographic alignment of the entire superlattice, expanding the potential of crystal engineering with DNA through physical and chemical control.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ho Fung Cheng, Shunzhi Wang, Chad A. Mirkin
Summary: Recent studies have shown that PAEs can behave as electron equivalents at small size and low DNA grafting density, however, the polydispersity in the number of DNA strands on the surfaces of these NPs limits the structural uniformity and tailorability of NP-based EEs. By assembling molecularly precise EEs with complementary NP-based PAEs, three distinct metallic phases can be formed, demonstrating that molecular-based EEs can influence specific phase formation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Jingshan S. Du, Wenjie Zhou, Sara M. Rupich, Chad A. Mirkin
Summary: The structure of MTPs is determined by specific crystallographic features, and their formation pathways include growth from multiply twinned seeds or stepwise formation of new twin boundaries on single-crystalline seeds. Recent studies have utilized in situ transmission electron microscopy to provide real-time evidence for both pathways, which will aid in the design of robust MTP syntheses. Further research on the structural evolution and energetics of nanoparticles is needed for a complete understanding of MTP formation pathways.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Ho Fung Cheng, McKinley K. Paul, Andrea D'Aquino, Charlotte L. Stern, Chad A. Mirkin
Summary: The study reveals that in a multiphasic solvent environment, dynamic weak-link approach (WLA) complexes demonstrated the ability to shuttle between aqueous and organic phases and modulate their denticity as they partition into different phases. This highly reconfigurable property of WLA complexes can be utilized to design biphasic reaction networks or chemical separations driven by straightforward salt metathesis reactions.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sasha B. Ebrahimi, Devleena Samanta, Benjamin E. Partridge, Caroline D. Kusmierz, Ho Fung Cheng, Arabela A. Grigorescu, Jorge L. Chavez, Peter A. Mirau, Chad A. Mirkin
Summary: Researchers have developed a strategy based on forced intercalation (FIT) to transduce subtle changes in aptamer structures into fluorescent readouts, expanding the scope of aptamer recognition for detecting steroids. This technology offers advantages such as rapid readout, simple instrumentation, and low sample volumes for studying steroids in clinical samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Adam Ponedal, Shengshuang Zhu, Anthony J. Sprangers, Xiao-Qi Wang, David C. Yeo, Daniel C. S. Lio, Mengjia Zheng, Matthew Capek, Suguna P. Narayan, Brian Meckes, Amy S. Paller, Chenjie Xu, Chad A. Mirkin
ACS APPLIED BIO MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Abha Gosavi, Chad Mirkin, Justin Notestein
Article
Chemistry, Analytical
Sarah E. Anderson, Natalie S. Fahey, Jungsoo Park, Patrick T. O'Kane, Chad A. Mirkin, Milan Mrksic
