Article
Orthopedics
Jay R. Ebert, Michael Fallon, David J. Wood, Gregory C. Janes
Summary: MACI showed high levels of satisfaction and adequate graft survivorship as visualized on MRI at 10.5 to 16 years after surgery. Most patients reported high levels of satisfaction with their ability to participate in sports, but previous surgical procedures may be negatively associated with certain outcome measures.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arya Haj-Mirzaian, Bahram Mohajer, Ali Guermazi, Frank W. Roemer, Bashir Zikria, Shadpour Demehri
Summary: This study aimed to investigate the association between kneeling activity and worsening of patellofemoral joint cartilage damage in subjects with and without patella alta. The results showed that a higher frequency of kneeling activity was associated with increased risk of cartilage score worsening, especially for those engaging in kneeling activity for >= 6 days per week. Further stratification analysis indicated a more significant association between kneeling activity and cartilage score deterioration in patients with patella alta.
EUROPEAN RADIOLOGY
(2021)
Review
Orthopedics
Alessandra Colombini, F. Libonati, S. Lopa, G. M. Peretti, M. Moretti, L. de Girolamo
Summary: This study evaluated the long-term efficacy of autologous chondrocyte implantation (ACI) and matrix-assisted chondrocyte implantation (MACI) in treating knee cartilage defects in patients with osteoarthritis (OA). Results showed that both ACI and MACI showed sustained clinical improvements and delayed the need for arthroplasty.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Orthopedics
Hayden B. Schuette, Matthew J. Kraeutler, John B. Schrock, Eric C. McCarty
Summary: A systematic review comparing primary versus secondary autologous chondrocyte implantation (ACI) in knee joints found that patients undergoing secondary ACI have a significantly higher risk of treatment failure and may experience worse subjective outcomes compared to those undergoing primary ACI.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Matthias Jung, Dimitrios C. Karampinos, Christian Holwein, Joachim Suchowierski, Thierno D. Diallo, Alexandra S. Gersing, Fabian Bamberg, Frederic A. Baumann, Stefan Ruschke, Pia M. Jungmann
Summary: The study evaluated the association of MRI parameters of cartilage repair tissue and subchondral bone marrow with morphologic and clinical outcomes after MACI with ABG of the knee. The results showed that MRI parameters were correlated with cartilage repair tissue quality and clinical symptoms.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Daniel Koerner, Christoph E. Gonser, Stefan Doebele, Christian Konrads, Fabian Springer, Gabriel Keller
Summary: This study presents patient-reported outcome measures following matrix-associated autologous chondrocyte implantation and autologous bone grafting for high-stage osteochondral lesions of the talus in adolescents. The results show heterogeneous outcomes, with long-term limitations mainly affecting sports and recreational activities. Osteochondral lesions of the talus are associated with osteoarthritis, but significant progression was not found after the described procedures in the long term.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Anthony G. Schache, Prasanna Sritharan, Adam G. Culvenor, Brooke E. Patterson, Luke G. Perraton, Adam L. Bryant, Ali Guermazi, Hayden G. Morris, Timothy S. Whitehead, Kay M. Crossley
Summary: Patellofemoral joint (PFJ) osteoarthritis is common following anterior cruciate ligament reconstruction (ACLR) and altered joint loading may contribute. This study examined the relationship between PFJ loading and prevalent and worsening PFJ osteoarthritis post-ACLR. The results showed that lower peak PFJ contact force was associated with prevalent early PFJ osteoarthritis at 1-year post-ACLR and a higher risk of worsening PFJ osteoarthritis between 1- and 5-years post-ACLR.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Jay R. Ebert, Michael Fallon, David J. Wood, Gregory C. Janes
Summary: The study found that an accelerated return to full weight bearing after matrix-induced autologous chondrocyte implantation (MACI) at 6 weeks provided comparable clinical and MRI-based outcomes beyond 5 years post-surgery, without jeopardizing the graft. This 6-week protocol is faster than previously proposed and studied protocols.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
Alexandre Barbieri Mestriner, Jakob Ackermann, Gergo Merkely, Pedro Henrique Schmidt Alves Ferreira Galvao, Luiz Felipe Morlin Ambra, Andreas H. Gomoll
Summary: The etiology of cartilage lesions did not affect clinical outcomes after second-generation ACI in the PFJ in this retrospective study.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Sprlakova-Pukova, Alena Stouracova, Martin Repko, Eva Koritakova, Jaroslav Tintera, Marek Dostal, Tomas Otasevic
Summary: The study found that there were no significant differences in the treatment effects of microfractures and scaffold implantation on cartilage defects at 6, 12, and 18 months. More substantial decrease in GAGs concentration was observed at month 6 with microfracture treatment, while the greatest decline was seen at month 12 with implantation. The decline in GAGs content and cartilage quality was also significant in the reference area and close surroundings.
ACADEMIC RADIOLOGY
(2021)
Article
Orthopedics
Kyoung Ho Yoon, Sang Jun Song, Sung Hyun Hwang, Woo Jae Jang, Cheol Hee Park
Summary: This study retrospectively analyzed the clinical, radiographic, and MR results of CCP-ACI in patients with ODs up to 10mm in depth. The results showed that CCP-ACI provided acceptable mid-term outcomes without the need for bone grafting.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Yufeng Liu, Ning Ma, Zhe Zhao, Quanyi Guo
Summary: This retrospective study evaluated the safety, efficacy, and outcomes of using allogenic next-generation MACI for the treatment of cartilage defects in the knee joint. The results showed that this method is a safe and effective option with lasting benefits for over 5 years. The size of the defects was found to have a significant impact on postoperative clinical outcomes.
ORTHOPAEDIC SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Yang Fan, Yan-Wei Lin, Ruo-Yang Shi, Ling-Zhan Yu, Rui Wu, Qiu-Ying Yao, Luke D. Wesemann, Jiani Hu, Qi Liu, Yan Zhou, Sheng Chen, Lian-Ming Wu
Summary: Creatine distribution in myocardial segments of idiopathic inflammatory myopathy (IIM) patients was measured using cardiovascular magnetic resonance (CMR) chemical exchange saturation transfer (CEST) creatine mapping. CEST showed increased sensitivity in detecting subclinical myocardial changes compared to conventional CMR mapping sequences, making it a promising CMR sequence for screening subclinical myocardial damage.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Moritz Riedl, Henriette Bretschneider, Michael Dienst, Klaus-Peter Guenther, Stefan Landgraeber, Jorg Schroeder, Siegfried Trattnig, Stefan Fickert
Summary: Injectable matrix-associated, autologous chondrocyte transplantation (MACT) can significantly improve symptoms, function, and quality of life in patients with focal chondral lesions caused by femoroacetabular impingement (FAI) of the hip joint, while successfully repairing the cartilage defect.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Linyao Li, Maojuan Liu, Siyu Deng, Xiaokang Zhu, Yang Song, Erqun Song
Summary: A peptide-modified magnetic resonance tuning (MRET) probe was used to achieve highly sensitive magnetic resonance imaging (MRI) of bacterial infection in vivo by responding to matrix metallopeptidase 2 (MMP-2) highly expressed in bacteria-infected microenvironments. The probe showed T-2-weighted signal and T-1-weighted signal, allowing for accurate differentiation between sterile inflammation and bacterial infection.
Article
Anesthesiology
Robert Waller, Anne Julia Smith, Thomas Graven-Nielsen, Lars Arendt-Nielsen, Michele Sterling, Jaro Ilari Karppinen, Peter Bruce O'Sullivan, Leon Melville Straker, Helen Slater
Article
Surgery
Jay R. Ebert, Nils O. Nivbrant, Victoria Petrov, Piers Yates, David J. Wood
Summary: This study evaluated the 2-year clinical results and periprosthetic bone mineral density (BMD) changes in patients undergoing primary cemented total hip arthroplasty (THA) using a new femoral stem. The results showed that the new stem demonstrated good clinical outcomes, consistent BMD changes, and similar patterns of post-operative micromotion compared to other successful cemented stems.
ANZ JOURNAL OF SURGERY
(2022)
Article
Orthopedics
Michael Beere, Jay R. Ebert, Brendan Joss, Timothy Ackland
Summary: This study investigated the suitability of isometric strength testing methods as an alternative to isokinetic assessment for identifying knee extensor strength asymmetry. The results suggest that isometric methods can be used to assess knee extensor strength in the absence of isokinetic testing equipment, with consideration of test angles being important. ACL reconstruction patients demonstrated greater asymmetry in knee extensor strength compared to healthy controls, highlighting the importance of assessing strength deficits in this population.
Article
Orthopedics
Jay R. Ebert, Robert Nairn, William Breidahl, Peter T. Annear
Summary: Comparable outcomes were observed after double-bundle ACLR using autologous hamstrings with, or without, LARS augmentation. Therefore, while these outcomes do not justify the additional use of synthetic augmentation given the lack of further benefit and additional cost, higher rates of graft failure, synovitis and early osteoarthritic change previously reported were not observed.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Nutrition & Dietetics
Marc K. K. Smith, Jonathan M. D. Staynor, Amar El-Sallam, Jay R. R. Ebert, Tim R. R. Ackland
Summary: Smartphone applications now provide accessible in-home monitoring of individual health biomarkers. This research assessed the longitudinal agreement of a novel smartphone application for measuring body composition during a weight loss intervention. The results showed small mean differences between the smartphone app and the ground truth methods, indicating acceptable accuracy. The smartphone app offers significant benefits in terms of cost, accessibility, and user comfort.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Orthopedics
Benjamin A. Southi, Callum Fryer, Jay Ebert, Tim Ackland, Markus S. Kuster, Nicholas D. Calvert
Summary: This study compared the kneeling ability and self-reported knee function of patients with distal tibia fractures managed with either intramedullary nailing (IMN) or open reduction internal fixation (ORIF) with compression plating. The results showed that patients with IMN had significantly worse kneeling function compared to their non-affected limb and the ORIF group. Additionally, the IMN group had worse overall knee function compared to the ORIF group.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Orthopedics
Jay R. Ebert, Antony C. Raymond, Randeep S. Aujla, Peter D'Alessandro
Summary: For patients with symptomatic FAIS lasting more than 6 months, intra-articular hip injection and structured exercise rehabilitation program can significantly improve hip pain, symptoms, and physical function, making nonoperative management possible.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Jay R. Ebert, Mikhil Jain, Gregory C. Janes
Summary: This study aimed to evaluate the clinical outcome, patient satisfaction, re-injury and re-operation rates of patients 7-10 years after augmented hip abductor tendon repair. The results showed good clinical scores, high patient satisfaction and an acceptable re-injury rate at 7-10 years after the surgery.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
John P. Scanlon, Antony C. Raymond, Randeep S. Aujla, Satyen Gohil, Jay R. Ebert, Li-On Lam, Shahbaz S. Malik, Ashley Simpson, Jacobus H. Otto, Declan Neeson, Peter D'Alessandro
Summary: The study aims to report the outcomes of patients with osteochondral injuries secondary to acute traumatic patella dislocation treated with combined early fragment fixation and MPFL reconstruction using a quadriceps tendon graft. The results suggest that the combined approach using a quadriceps tendon graft offers good radiological and patient-reported outcomes.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Medicine, Research & Experimental
Jay R. Ebert, Agnes Magi, Eve Unt, Ele Prans, David J. Wood, Sulev Koks
Summary: This study aimed to identify genetic variations associated with high-level athletic performance and lower limb musculoskeletal injury. Through genome-wide association analysis, the researchers discovered single-nucleotide polymorphisms (SNPs) that are related to performance and injury. The findings are important for the development of individualized training and injury rehabilitation programs.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Orthopedics
Mira Marinova, Abayasankar Sundaram, Katie Holtham, Jay R. Ebert, David Wysocki, Daniel Meyerkort, Ross Radic
Summary: The study aimed to compare the effectiveness of cryocompression treatment with usual care protocol on early post-operative recovery following total knee arthroplasty. The results showed that cryocompression treatment significantly improved knee extension during the initial two-week intervention period, but no further significant differences were observed between the groups during or after the intervention.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Jay R. Ebert, William Breidahl, Sven Klinken, Peter T. Annear
Summary: This study developed and assessed a MRI-based scoring tool for evaluating surgical repair after proximal hamstring avulsions and its correlation with patient-reported outcome. The results showed excellent reliability of the scoring tool and its potential value in both research and clinical settings.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
Anne Smith, Kate M. Dunn
JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Orthopedics
Jay R. Ebert, Peter Edwards, Peter T. Annear
Summary: This study evaluated the clinical outcomes of ACLR using autologous hamstrings augmented with suture tape. The results showed good clinical outcomes, high rates of return to sport, and low re-injury rates at 24 months.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)