Article
Chemistry, Analytical
Qingfang Niu, Pengyue Jin, Yu Huang, Lifang Fan, Caihong Zhang, Cheng Yang, Chuan Dong, Wenting Liang, Shaomin Shuang
Summary: In this study, a novel nanocomposite 3D-rGO/Pd@Au/CM-beta-CD was developed for the electrochemical enantiorecognition of tyrosine. Under the optimized determining conditions, this approach accurately determines the relative content of l- or d-Tyr enantiomers in a racemic solution.
Article
Chemistry, Physical
Jingchao Chen, Ximing Huang, Na Li, Haixia Guo, Zhiming Gao, Huibo Shao
Summary: This study investigated the interaction between an amino acid and a simulated cell membrane through hydrogen bonding, revealing that increasing negative surface charge density enhances the strength of hydrogen bonds. This was supported by the larger values of the binding constants. The research provided valuable insights for the quantitative analysis of hydrogen bonds between amino acids and simulated cell membranes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Shah Ekramul Alom, Rajaram Swaminathan
Summary: UV-Visible absorption and luminescence from non-aromatic groups in proteins, known as Protein Charge Transfer Spectra (ProCharTS), are currently being investigated. This study showed that various charged amino acids, homo-polypeptides, and a protein rich in aspartate, histidine, and arginine displayed ProCharTS. The results suggest that ProCharTS can be used as a spectral probe to study the structure of proteins rich in charged amino acids.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Organic
Kiran Bajaj, Karishma Pidiyara, Shahid Khan, Prabhat N. Jha, Rajeev Sakhuja, Dalip Kumar
Summary: This study focused on the synthesis and characterization of fluorescent labeled glutamine and asparagine derivatives with high fluorescence quantum yields and excellent photostabilities using traceless Staudinger ligation. The successful permeation of these fluorescent amino acids into cellular components demonstrated their potential as fluorescent probes for chemical biology.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Joongoo Lee, Kevin J. Schwarz, Hao Yu, Antje Kruger, Eric Anslyn, Andrew D. Ellington, Jeffrey S. Moore, Michael C. Jewett
Summary: This study reports a method for fluorescent labeling of amino acids catalyzed by flexizyme, and demonstrates the site-specific incorporation of these fluorescent amino acids into peptides by the ribosome in vitro through genetic code reprogramming.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yaxian Lin, Yangyang Jiang, Ziwei Zhao, Yueyang Lu, Xinping Xi, Chengbang Ma, Xiaoling Chen, Mei Zhou, Tianbao Chen, Chris Shaw, Lei Wang
Summary: Temporin-PKE is a novel peptide extracted from the skin secretion of Pelophylax kl. esculentus, which displays strong antimicrobial activity and cytotoxicity. Strategies for modifications include incorporating positively charged residues, D-amino acids, and altering the side chain amino acids. The optimal analogue, Temporin-PKE-3K, exhibits dual efficient functions, strong antimicrobial and anticancer activity.
Article
Chemistry, Multidisciplinary
Sahabaj Mondal, Surajit Singh, Ananda Shit, Santosh Kumar, Debasish Haldar
Summary: The tryptophan-mediated photo cleavage of disulfide bonds and resulting defibrillation process has been demonstrated. A supramolecular fiber-like network structure is formed through the self-assembly of dibenzyloxycarbonyl-L-cystine by non-covalent interactions, resulting in a hydrogel. The hydrogel shows thixotropic properties and is responsive to heat and pH. However, UV irradiation leads to disulfide bond cleavage, causing defibrillation and a gel-to-sol transition. The fiber exhibits amyloid-like structure and positive results in the Congo red assay.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Simona Rinaldi, Sabrina Di Giovanni, Giuliano Palocci, Michela Conto, Roberto Steri, Carmela Tripaldi
Summary: This study investigated the impact of milk heat pre-treatment and pasteurization level on the protein digestibility of produced cheese. In vitro digestion method was used to analyze the peptide profile and amino acids released in digestion. The results showed the importance of heat treatment management on protein digestibility in soft cheese.
Review
Chemistry, Multidisciplinary
Yulun Wu, Huangxu Li, Tiancheng Liu, Ming Xu
Summary: This review comprehensively examines the use of proteins and their subunits in addressing engineering issues in various rechargeable batteries. The latest advances in electrode, electrolyte, separator, and other components are discussed, with a particular emphasis on the impact of biomolecules on electrochemical properties.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Jinjin Xue, Panpan Liu, Lin Feng, Lin Zheng, Anhui Gui, Xueping Wang, Shengpeng Wang, Fei Ye, Jing Teng, Shiwei Gao, Pengcheng Zheng
Summary: The effects of different fixation methods on the chemical characteristics of green tea were studied. The results showed that high-temperature fixation induced changes in protein oxidation, degradation of flavonoid glycosides, and epimerization of catechins, leading to the accumulation of amino acids, peptides, flavonoids, and catechins, which influenced the taste of green tea.
Article
Chemistry, Multidisciplinary
Yiyin Xia, Janet To, Ning-Yu Chan, Side Hu, Heng Tai Liew, Seetharamsing Balamkundu, Xiaohong Zhang, Julien Lescar, Surajit Bhattacharjya, James P. Tam, Chuan-Fa Liu
Summary: This study found that Asn(OH) is an unnatural substrate for PALs, and successfully synthesized a new MMP2 inhibitor cyclic peptide using Asn(OH)-mediated cyclization, with the hydroxamic acid moiety as the key pharmacophore. Several bioactive Asp-containing cyclic peptides were also synthesized using this approach, demonstrating the effectiveness of substrate engineering in expanding the application of PAL ligation in the synthesis of therapeutic cyclic peptides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Article
Plant Sciences
Zivile Taraseviciene, Aloyzas Velicka, Aurelija Paulauskiene
Summary: The research showed that foliar application of amino acids can significantly increase the total phenol content in mint plants, especially with the most pronounced effect from tryptophane. Different mint varieties have varied responses to amino acid applications, highlighting the individualized nature of biophenol content based on factors such as foliar application and variety.
Article
Biochemical Research Methods
Hayden R. Anderson, Wei L. Reeves, Andrew T. Bockus, Paolo Suating, Amy G. Grice, Madeleine Gallagher, Adam R. Urbach
Summary: We have developed a novel insulin derivative that exhibits high nanomolar affinity for the synthetic receptor cucurbit[7]uril (Q7), potentially enabling the development of continuous insulin detection methods for diabetes management.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Stanislav Zalis, Jan Heyda, Filip Sebesta, Jay R. Winkler, Harry B. Gray, Antonin Vlcek
Summary: The study elucidates the mechanism of charge transport over long distances through hole hopping via tryptophan/tyrosine chains, with experimental and theoretical analyses revealing key factors influencing the process. Experimental kinetics investigations demonstrated the acceleration effect of closely spaced tryptophans on long-range electron transfer, while theoretical calculations identified crossings between sensitizer-localized and charge-separated states in excited-state trajectories.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
