Review
Orthopedics
Camila Grant, Cameron N. Fick, Judith Welsh, Jenny McConnell, Frances T. Sheehan
Summary: This study revealed significant methodological variability in the literature on patellofemoral pain, hindering the determination of pain causes and limiting the generalizability of results. While meta-analyses supported the diagnostic value of maltracking in patellofemoral pain, issues with inconsistent measurement methods and inadequate control for confounding variables persist.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Engineering, Aerospace
Or D. Dantsker, Mirco Theile, Marco Caccamo
Summary: This work presents a cyber-physical prototyping and testing framework for enabling the rapid development of UAVs. The framework allows for iteration throughout the entire development process and includes seven novel methods and tools applicable to various areas of fixed-wing UAV development.
Article
Engineering, Biomedical
Emily R. Triolo, Brett F. BuSha
Summary: The study aimed to design and build a five-fingered powered assistive exoskeleton for the human hand, and assess its ability to augment grip strength and assist in daily activities. The results showed that the device significantly reduced forearm muscle activity and improved grasping and pinching efforts, but did not provide benefits for maintaining minimal pinching effort or certain functional tests.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Biophysics
Cameron N. Fick, Rafael Jimenez-Silva, Frances T. Sheehan, Camila Grant
Summary: Due to the multifactorial nature of patellofemoral pain, it is often difficult to identify the exact cause of pain for individual patients. This retrospective study found that demographic factors such as weight and height can influence the patellofemoral kinematics in patients with patellofemoral pain. Specifically, weight influenced patellar shift and flexion, while height influenced patellar flexion. The findings suggest the importance of considering demographic factors in future studies and clinical interventions.
JOURNAL OF BIOMECHANICS
(2022)
Review
Orthopedics
Filippo Migliorini, Andromahi Trivellas, Jorg Eschweiler, Marcel Betsch, Markus Tingart, Nicola Maffulli
Summary: This systematic review evaluated the use of pedicled quadriceps tendon autograft for primary MPFL reconstruction in patients with recurrent patellofemoral instability. The results showed significant improvements in clinical scores postoperatively, with low complication rates. This technique appears to be a suitable choice for patients with recurrent patellar instability, although more studies are needed to compare its efficacy with other graft sources.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Business
Birgit Pena Haeufler, Dietfried Globocnik, Paola Landaeta Saldias, Soren Salomo
Summary: This research proposes rapid validity testing (RVT) as a method to reduce uncertainty in the front-end of innovation processes and increase the likelihood of achieving high-quality innovation outcomes on time and within budget. The effectiveness of RVT is influenced by technological turbulence, the organization's long-term orientation, and risk propensity. Empirical evidence from the study suggests that organizations implementing RVT in their innovation activities achieve higher performance in their innovation programs.
JOURNAL OF PRODUCT INNOVATION MANAGEMENT
(2021)
Article
Thermodynamics
Jhen-Syuan Huang, Chin-Hsiang Cheng
Summary: This paper presents a theoretical model for analyzing the performance of a rotary-integral Stirling cryocooler. Transient variations of thermodynamic properties are used to predict cooling temperature and capacity. A precise evaluation method for the regenerator is introduced, and temperature and pressure dependent thermophysical properties are considered. An experimental prototype is manufactured and numerical results from the model are validated. The results show good agreement between the predicted and measured values, indicating the effectiveness of the proposed model. Parametric studies are also conducted to explore performance enhancements.
THERMAL SCIENCE AND ENGINEERING PROGRESS
(2023)
Article
Multidisciplinary Sciences
Carlie Rein, Mehmet Toner, Derin Sevenler
Summary: Soft lithography allows rapid prototyping of precise microfluidic features using a deformable elastomer like polydimethylsiloxane (PDMS). However, for applications where flexibility of PDMS is a drawback, more rigid materials like epoxy and glass have been proposed. Devices fabricated from epoxy and glass offer superior mechanical performance, feature resolution, and solvent compatibility compared to alternatives. This article presents a detailed step-by-step method for fabricating rigid microfluidic devices from soft lithography patterned epoxy and glass, demonstrating their use in high throughput cell focusing with rigid high aspect ratio spiral microchannels.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Orthopedics
Nikolaos K. Paschos
Summary: When looking at stars, we are looking back in time as it takes years for their light to reach us. Similarly, in evaluating data on osteoarthritis after patellofemoral surgery, the type of procedure performed and whether it causes the arthritis or the patellofemoral instability itself does is important to consider. Recent evidence suggests that surgical restoration of the anatomy and biomechanics of the patellofemoral joint can significantly reduce the risk of osteoarthritis, which is caused by recurrent patellofemoral instability leading to cartilage degeneration. However, the loading of cartilage and possible over-constraint from surgery can also contribute to arthritis.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Review
Medicine, General & Internal
Yong-qiang Zhang, Zhao Zhang, Meng Wu, Ya-dong Zhou, Sheng-lin Tao, Ya-long Yang, Yang Li, Jun-liang Liu, Peng Li, Yun-sheng Teng, Yong-ming Guo
Summary: MPFL reconstruction is a reliable technique for the treatment of patellofemoral instability. The SchOttle point remains the mainstream method for determining the femoral attachment, with the patellar attachment for single-bundle located at the junction of the proximal one third and the distal two third of the longitudinal axis of the patella. For double-bundles, one is located at the proximal one third of the medial patellar edge and another is at the center of the patellar edge. Adjusting the graft tension during surgery is crucial.
Article
Orthopedics
Junjie Xu, Zipeng Ye, Yi Qiao, Caiqi Xu, Kang Han, Jiebo Chen, Shikui Dong, Jinzhong Zhao
Summary: The study compared the graft length change patterns in different medial patellofemoral ligament reconstruction methods and found that anatomic reconstruction had more isometric graft behavior, while nonanatomic attachments and reconstructions resulted in significant anisometric graft length changes and limited favorable isometric ranges.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Orthopedics
Alexander E. Loeb, Jack Farr, Shital N. Parikh, Andrew J. Cosgarea
Summary: Noniatrogenic medial patellar dislocations are extremely rare, and treatment for first-time medial patellar instability in patients without known risk factors should follow the same nonoperative principles as lateral instability with no known risk factors. Surgery may be appropriate for patients with documented risk factors and recurrence.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Yuta Fujii, Shuji Nakagawa, Yuji Arai, Hiroaki Inoue, Hiroyuki Kan, Manabu Hino, Kenta Kaihara, Yasuo Mikami
Summary: The post-operative outcomes of MPFL reconstruction for recurrent patellar dislocation are favorable, but it is important to note the potential insufficient union between the bone tunnel and tendon graft, as well as elongation of the necrotic tendon graft, which may alter the alignment of the patellofemoral joint within three months after the operation.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Engineering, Manufacturing
Saja Aabith, Richard Caulfield, Omid Akhlaghi, Anastasia Papadopoulou, Shervanthi Homer-Vanniasinkam, Manish K. Tiwari
Summary: Direct-write printing has been instrumental in additive manufacturing, especially in extrusion-based printing, expanding the range of materials and applications. However, the synthesis and preparation of printing inks for direct-write printing can be complex. This study develops a precise 3D printable polymer that allows for the easy prototyping of micrometre-scale silicone structures without the need for cleanroom facilities.
ADDITIVE MANUFACTURING
(2022)
Article
Orthopedics
Nik Zlak, Alan Kacin, David Martincic, Matej Drobnic
Summary: This study evaluated the predicting factors for patient-reported outcomes and revision interventions following surgical treatment of patellofemoral instability. The results showed that surgical treatment significantly improved knee function and patient quality of life. However, there is a risk of second surgical interventions, mainly due to hardware or arthrofibrosis.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Daiwei Yao, Imran Akram, Kiriakos Daniilidis, Luc Labey, Bernardo Innocenti, Carsten Tibesku
Summary: This study compared the effectiveness of BKA and TKA in restoring the kinematics of the knee joint, finding that under passive conditions, BKA can achieve similar kinematics to a natural knee joint, but no functional advantage of BKA over TKA was detected under weight-bearing conditions.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Caroline Struijk, Wouter Van Genechten, Peter Verdonk, Aaron J. Krych, Allan B. Dietz, Andre J. van Wijnen, Daniel B. F. Saris
Summary: This study demonstrates the feasibility of injecting doses of MSCs (>0.1 million) in meniscus allograft tissue with active cell proliferation, migration, and robust cell survival.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Albert H. van Houten, Petra J. C. Heesterbeek, Gerjon Hannink, Luc Labey, Ate B. Wymenga
Summary: This study assessed the impact of insert articular surface geometry on AP translation and VV laxity in balanced PCL-retaining TKA. Results showed limited effect of insert geometry on stability, and reconstructed knee approximated the laxity of the native knee.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Orthopedics
Jacques Hernigou, Peter Verdonk, Yasuhiro Homma, Rene Verdonk, Stuart B. Goodman, Philippe Hernigou
Summary: Orthoregeneration is a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing and function, using various options like drugs, surgery, scaffolds, biologics, and physical stimuli. The goal of regenerative medicine is to enhance tissue healing after musculoskeletal injuries, with promising and established treatment modalities for conditions like osteonecrosis and chondral lesions involving the hip.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Orthopedics
Andrew D. Firth, Dianne M. Bryant, Robert Litchfield, Robert G. McCormack, Mark Heard, Peter B. MacDonald, Tim Spalding, Peter C. M. Verdonk, Devin Peterson, Davide Bardana, Alex Rezansoff, Alan M. J. Getgood
Summary: This study identified predictors of ACL graft failure in high-risk patients and indicated that adding a lateral extra-articular tenodesis (LET) and using a larger graft diameter can significantly reduce the odds of asymmetric pivot shift. Conversely, factors such as younger age, greater posterior tibial slope, high-grade knee laxity, and earlier return to sport were associated with increased odds of graft rupture.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Rheumatology
Marie-Noelle Horcajada, Maurice Beaumont, Nicolas Sauvageot, Laure Poquet, Madleen Saboundjian, Berenice Costes, Peter Verdonk, Geoffrey Brands, Jean Brasseur, Didier Urbin-Choffray, Marc Vandenberghe, Karl Brabants, Kurt De Vlam, Werner Fache, Bernard Jandrain, Vincent Grek, Michel Malaise, Yves Henrotin
Summary: The study found that olive leaf extract (OLE) has limited effects on knee functionality and biomarkers of bone/cartilage metabolism and inflammation, but may be effective in patients with severe walking pain. OLE can be used to relieve knee joint pain and enhance mobility.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Orthopedics
Hana Marmura, Andrew Firth, Lachlan Batty, Dianne M. Bryant, Alan M. J. Getgood
Summary: Repairing the medial meniscus may result in a small reduction in PROM scores at two-year follow-up, but these differences are not likely to be important to patients or clinicians.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Raju Easwaran, Moin Khan, Parag Sancheti, Ashok Shyam, Mohit Bhandari, Anil S. Ranawat, Savyasachi Thakkar, Shital Parikh, Volker Musahl, Siddharth Joglekar, Ajit J. Deshmukh, Kevin Plancher, Nikhil Verma, David McAllister, Peter Verdonk, Sebastien Lustig, Amit Chandrateya, Robert Smigleiski, Gandhi Solayar, Bancha Chernchujit, Patrick Yung, Nicolaas Budhiparama, Yuichi Hoshino, Nathan White, David Parker, Mark Clatworthy, Charlie Brown, Mojieb Manzary, David Rajan, Abhay Narvekar, Sachin Tapasvi, Dinshaw Pardiwala, Ranjit Panigrahi, S. Arumugam, Vikash Kapoor, Bharat Mody, Jitender Maheshwari, Vivek Dahiya, Clement Joseph, Mukesh Laddha, Ashok Rajgopal
Summary: There is a lack of consensus on the need for Venous Thrombo Embolism (VTE) prophylaxis following arthroscopic knee surgery and open soft tissue knee reconstruction. This study conducted a modified Delphi questionnaire to gather opinions from international experts. The results showed that there are certain patient factors, prolonged surgery duration, and family history of thrombogenic events that should be taken into consideration for prophylaxis. The study concluded that there is a select group of patients undergoing arthroscopic surgery that justify the usage of VTE prophylaxis.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Parth Lodhia, Goris Nazari, Dianne Bryant, Alan Getgood, Robert McCormack
Summary: In patients undergoing ACL reconstructions with 4-strand and 5-strand hamstring autografts of >= 8mm diameter for ACLR or ACLR + LET, there were no significant differences in clinical outcomes and patient-reported outcomes at the 24-month follow-up. The 5-strand hamstring autograft configuration is a viable option for producing larger-diameter ACL grafts.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Neurosciences
Laure Everaert, Eirini Papageorgiou, Anja Van Campenhout, Luc Labey, Kaat Desloovere
Summary: The prevalence and specific features of AFOs in children with CP were examined, and it was found that rigid AFOs were most commonly prescribed. AFOs were found to improve gait, particularly for specific gait patterns such as crouch and apparent equinus.
Article
Computer Science, Information Systems
Yang Zhang, Mathieu Bressel, Sander De Groof, Francois Domine, Luc Labey, Laurent Peyrodie
Summary: This paper presents a novel lower-limb exoskeleton design for children, with adjustable size to suit children from 8 to 12 years old. The exoskeleton employs six active joints on the knee and hip, actuated by Brushless DC motors and Harmonic Drive gears. The controller is based on a finite state machine model and utilizes weight shift between two feet to generate the gait trajectory. An innovative automatic step-triggering mechanism is proposed, based on ground reaction force sensor feedback. User interfaces on the exoskeleton and host PC are designed for easy operation. Experimental results show that the exoskeleton effectively follows the gait trajectory and enables users to complete tasks with reduced effort.
Review
Rehabilitation
Sophie Vervullens, Lotte Meert, Isabel Baert, Rob J. E. M. Smeets, Peter Verdonk, Frank Rahusen, Mira Meeus
Summary: This study analyzed whether non-surgical, non-pharmacological prehabilitation in patients with knee osteoarthritis awaiting total knee arthroplasty was stratified based on clinical phenotypes or specific individual characteristics and summarized and compared the long-term effects of stratified and non-stratified care on pain, satisfaction, function, and quality of life. The study found that stratified prehabilitation targeting specific clinical phenotypes had a positive impact on function at 6 months, while stratified prehabilitation targeting specific individual characteristics had a positive impact on satisfaction. Non-stratified prehabilitation had positive effects on pain and function.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Computer Science, Information Systems
Sander De Groof, Yang Zhang, Laurent Peyrodie, Luc Labey
Summary: This paper presents a torque-controlled hip flexion/extension exoskeleton designed for individuals with cerebral palsy. It aims to mitigate hip extension deficit and excessive hip flexion observed in specific gait patterns. The exoskeleton features series elastic actuators and individualized orthotics, providing a higher extension torque during the stance phase.
Article
Orthopedics
Theofylaktos Kyriakidis, Nikolaos Tasios, Bruno Vandekerckhove, Peter Verdonk, Michiel Cromheecke, Rene Verdonk
Summary: This study evaluated the functional outcomes after posterior capsular release in patients with fixed flexion deformity greater than 15 degrees. The results demonstrated that posterior open release via the posteromedial approach was an efficient and safe procedure for treating persistent fixed flexion deformity following total knee arthroplasty at two years of follow-up.
ACTA ORTHOPAEDICA BELGICA
(2022)
Article
Orthopedics
Romulo Silva, Eva Campos Pereira, Marco Distefano, Roskams Toon, Jeroen Verhaegen, Koen Lagae, Peter Verdonk
Summary: In this article, a technique using a vascular prosthesis to augment the repair of the knee extensor apparatus is presented. This method promotes healing, does not cause donor morbidity or rejection risk, and allows for earlier mobilization and rehabilitation. Promising results were achieved in various cases with different etiologies requiring reinforcement.
