Article
Computer Science, Information Systems
Yamin Li, Wen Shi, Zhian Liu, Jing Li, Qiang Wang, Xiangguo Yan, Zehong Cao, Gang Wang
Summary: The study utilized advanced EEG microstate spectral analysis to evaluate brain states during propofol-induced sedation, showing promising performance in estimating the level of sedation. The selected spectral features demonstrated better performance in estimating brain states during sedation, exhibiting high correlations with individual behavioral data.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Multidisciplinary Sciences
Fangyun Tian, Laura D. Lewis, David W. Zhou, Gustavo A. Balanza, Angelique C. Paulk, Rina Zelmann, Noam Peled, Daniel Soper, Laura A. Santa Cruz A. Mercado, Robert A. Peterfreund, Linda S. Aglio, Emad N. Eskandar, G. Rees Cosgrove, Ziv M. Williams, R. Mark Richardson, Emery N. Brown, Oluwaseun Akeju, Sydney S. Cash, Patrick L. Purdon
Summary: By analyzing intracranial recordings, the authors found that ketamine engages different brain areas in distinct frequency-dependent patterns, which may be related to its dissociative and antidepressant effects. These findings could have implications for the development of biomarkers and new therapeutics for depression.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Neeraj Saxena, Suresh D. Muthukumaraswamy, Lewys Richmond, Adele Babic, Krish D. Singh, Judith E. Hall, Richard G. Wise, Alexander D. Shaw
Summary: The study revealed that propofol and dexmedetomidine produce contrasting effects on visual induced GBR, VEF, PMBR and MEF at equisedative doses.
Article
Anesthesiology
Lei Zhang, Kun Fang, Shengwei Tao, Liyun Deng, Hua Li, Yuanyuan Cao, Lei Wang, Fengqiong Yu, Erwei Gu
Summary: This study found that during propofol general anesthesia, dexmedetomidine (Dex) can induce EEG changes, enhancing slow waves and theta oscillation while reducing alpha oscillation, indicating that Dex helps deepen the depth of propofol-induced anesthesia.
PERIOPERATIVE MEDICINE
(2021)
Article
Clinical Neurology
Sowmya M. Ramaswamy, Maud A. S. Weerink, Michel M. R. F. Struys, Sunil B. Nagaraj
Summary: The study aims to investigate whether dexmedetomidine-induced deep sedation mimics natural sleep patterns using large-scale EEG recordings and machine learning techniques. The random forest algorithm trained on non-rapid eye movement stage 3 (N3) EEG patterns predicted dexmedetomidine-induced deep sedation state with high accuracy, outperforming other machine learning models. Power in the delta band, theta band, and beta band were identified as important features for prediction.
Review
Pharmacology & Pharmacy
Hua-Ze Ding, Yi-Ling Dong, Kai-Yue Zhang, Jia-Yu Bai
Summary: Dexmedetomidine administration had no significant effect on 28/30-day mortality and ventilator-free days in septic patients, but it could shorten the length of ICU stay.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Yi-Ting Chen, Cheuk-Kwan Sun, Kuan-Yu Wu, Ying-Jen Chang, Min-Hsien Chiang, I-Wen Chen, Shu-Wei Liao, Kuo-Chuan Hung
Summary: This study compared the sedation outcomes of dexmedetomidine and propofol during drug-induced sleep endoscopy (DISE). The results showed that compared with propofol, dexmedetomidine was associated with lower mSaO2 levels and a higher risk of hypoxemia, but provided higher satisfaction among endoscopic performers. However, propofol resulted in a shorter time to fall asleep and a lower risk of sedation failure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yoshinari Morimoto, Megumi Hayashi, Yuki Yao, Hitomi Nishizaki, Hidechika Ishii, Lou Mikuzuki, Kouji Hara
Summary: In elderly patients with severe dementia, intravenous sedation with MID caused a decrease in cerebral blood flow (CBF), while sedation with DEX maintained CBF.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Dmitriy Viderman, Fatima Nabidollayeva, Federico Bilotta, Yerkin G. Abdildin
Summary: This meta-analysis compared dexmedetomidine and propofol for intraoperative sedation in awake craniotomy and found no significant difference between the two in terms of intraoperative adverse events, patient satisfaction, or procedure duration, except for higher surgeon satisfaction in the dexmedetomidine group.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Review
Pharmacology & Pharmacy
Po Huang, Xiangchun Zheng, Zhi Liu, Xiaolei Fang
Summary: The meta-analysis compared dexmedetomidine and propofol for sepsis patients undergoing mechanical ventilation and found no significant difference in 28-day mortality, but dexmedetomidine showed benefits in reducing ICU stay, mechanical ventilation duration, and improving organ function. Further high-quality trials are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Michael P. Puglia, Duan Li, Aleda M. Leis, Elizabeth S. Jewell, Chelsea M. Kaplan, Megan Therrian, Minkyung Kim, UnCheol Lee, George A. Mashour, Phillip E. Vlisides
Summary: The study found that cortical complexity increases with age and decreases during general anesthesia. This association remained significant even when controlling for spectral changes during anesthetic-induced perturbations in consciousness, but not with developmental age.
Article
Biochemistry & Molecular Biology
Yuanyuan Gao, Fei Yan
Summary: This study compared the sedation effects of DEX-Midazolam and DEX-Propofol in patients undergoing major abdominal surgery. The results showed no significant differences in hemodynamic and respiratory changes between the two groups at different time intervals, as well as no significant differences in post-operative complications.
CURRENT DRUG METABOLISM
(2022)
Article
Clinical Neurology
Yali Chen, Shitong Li, Fan Wu, Ling Zou, Jun Zhang
Summary: The study demonstrates that propofol produces state-dependent effects on cortico-cortical undirected and directed functional connectivity. Propofol-induced unconsciousness is characterized by a decrease in functional connectivity and changes in the direction of information flow in the brain regions. This supports the idea that propofol-induced loss of consciousness may be through disrupting network interactions and cortical coordination.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Meteorology & Atmospheric Sciences
Florian Richter, Corneli Keim, Jerome Caron, Jasper Krauser, Dennis Weise, Mark Wenig
Summary: Wide-field spectrometers for Earth observation missions require in-flight radiometric calibration using the Sun as a known reference. Diffusers are used to scatter incoming light for homogeneous illumination, but can introduce interference patterns known as speckles leading to spectral features. Various methods have been implemented to characterize these features, with a proposed measurement technique based on acquiring monochromatic speckles for predicting spectral features in imaging spectrometers with few input parameters.
ATMOSPHERIC MEASUREMENT TECHNIQUES
(2021)
Article
Anesthesiology
Hansol Kim, Youngwon Kim, Jinyoung Bae, Seokha Yoo, Young-Jin Lim, Jin-Tae Kim
Summary: In this study of 103 patients undergoing spinal anesthesia, remimazolam showed superior sedation efficacy, shorter duration of effect, and fewer adverse events compared to dexmedetomidine. However, respiratory depression was more common with the use of remimazolam.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Anesthesiology
Tina B. McKay, James Rhee, Katia Colon, Katherine Adelsberger, Isabella Turco, Ariel Mueller, Jason Qu, Oluwaseun Akeju
Summary: This study aimed to identify novel serum biomarkers specific to postoperative delirium after major cardiac surgery, shedding light on the pathologic processes involved in delirium and its sequelae. Through a multiplexed proteomic approach, an increase in levels of FGF-21, FGF-23, interleukin-6, and monocyte chemotactic protein-3 in postoperatively delirious patients was identified, suggesting their role as potential systemic biomarkers for postoperative delirium after cardiac surgery.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Clinical Neurology
Zeynab Alshelh, Ludovica Brusaferri, Atreyi Saha, Erin Morrissey, Paulina Knight, Minhae Kim, Yi Zhang, Jacob M. Hooker, Daniel Albrecht, Angel Torrado-Carvajal, Michael S. Placzek, Oluwaseun Akeju, Julie Price, Robert R. Edwards, Jeungchan Lee, Roberta Sclocco, Ciprian Catana, Vitaly Napadow, Marco L. Loggia
Summary: This study suggests that patients with different chronic pain conditions exhibit neuroinflammation, which is accompanied by neurophysiological changes and correlates with clinical presentation. These findings contribute to the subtyping of distinct pain syndromes and provide potential targets for precision medicine.
Article
Hospitality, Leisure, Sport & Tourism
Lei Gao, Arlen Gaba, Peng Li, Richa Saxena, Frank A. J. L. Scheer, Oluwaseun Akeju, Martin K. Rutter, Kun Hu
Summary: This study found that the heart rate recovery (HRR) during exercise is associated with future risk for delirium in middle-to older-aged individuals. Those with lower HRR have a higher risk for developing delirium.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Surgery
Feng Liang, Kathryn Baldyga, Qimin Quan, Ashok Khatri, Shawn Choi, Jeanine Wiener-Kronish, Oluwaseun Akeju, M. Brandon Westover, Kathryn Cody, Yuan Shen, Edward R. Marcantonio, Zhongcong Xie
Summary: This study aimed to identify blood biomarkers of postoperative delirium and found that preoperative plasma concentrations of Tau-PT217 and Tau-PT181 were associated with the presence and severity of delirium after surgery.
Article
Clinical Neurology
Abigail A. Bucklin, Wolfgang Ganglberger, Syed A. Quadri, Ryan A. Tesh, Noor Adra, Madalena Da Silva Cardoso, Michael J. Leone, Parimala Velpula Krishnamurthy, Aashritha Hemmige, Subapriya Rajan, Ezhil Panneerselvam, Luis Paixao, Jasmine Higgins, Muhammad Abubakar Ayub, Yu-Ping Shao, Elissa M. Ye, Brian Coughlin, Haoqi Sun, Sydney S. Cash, B. Taylor Thompson, Oluwaseun Akeju, David Kuller, Robert J. Thomas, M. Brandon Westover
Summary: This study investigated the prevalence, severity, and risk factors of sleep-disordered breathing in ICU patients. The results showed that sleep-disordered breathing and sleep apnea events are common in ICU and are associated with hypoxia and periodic breathing. Limited bio-signals can be used for detection, but risk factors are insufficient for predicting the severity of AHI.
SLEEP AND BREATHING
(2023)
Article
Critical Care Medicine
Aiman Suleiman, Peter Santer, Ronny Munoz-Acuna, Maximilian Hammer, Maximilian S. Schaefer, Luca J. Wachtendorf, Sandra Rumyantsev, Lorenzo Berra, Shubham Chamadia, Oluwaseun Johnson-Akeju, Elias N. Baedorf-Kassis, Matthias Eikermann
Summary: This study found that ketamine infusion can increase inspiratory flow and reduce inspiratory work of breathing in intubated, spontaneously breathing patients, as well as activate the electroencephalogram. These characteristics might facilitate weaning from mechanical ventilation.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Clinical Neurology
Patrick A. Stokes, Preetish Rath, Thomas Possidente, Mingjian He, Shaun Purcell, Dara S. Manoach, Robert Stickgold, Michael J. Prerau
Summary: Transient oscillatory events in the sleep electroencephalogram, particularly sleep spindles, play important roles in memory consolidation, aging, and psychiatric and neurodegenerative disorders. This paper introduces a novel approach to electroencephalographic phenotyping, characterizing a generalized class of transient time-frequency events using continuous dynamics. The results demonstrate the stereotyped temporal evolution of transient events during sleep and the potential clinical applications in identifying differences in patients with schizophrenia.
Article
Multidisciplinary Sciences
Josue Chirinos, Isabella M. Turco, Raffaele F. Di Fenza, Stefano Gianni, Grant Larson, Joseph Swingle, Oluwaseun Akeju, Lorenzo Berra
Summary: The COVID-19 pandemic has had a significant impact on non-COVID-19 clinical research, but little is known about how patients have responded to clinical trial recruitment during this time. This study investigated the effect of the pandemic on patient consent rates for non-COVID-19 clinical trials, finding a significant decrease in consent rates during the pandemic.
Article
Medicine, General & Internal
Jason Z. Qu, Ariel Mueller, Tina B. McKay, Brandon Westover, Kenneth T. Shelton, Shahzad Shae, David A. D'Alessandro, Lorenzo Berra, Emery N. Brown, Timothy T. Houle, Oluwaseun Akeju
Summary: This study aimed to evaluate whether nighttime dexmedetomidine administration could reduce the incidence of postoperative delirium in elderly patients undergoing cardiac surgery. The results showed a significant reduction in delirium incidence on the first postoperative day in the dexmedetomidine group. Although the difference in delirium incidence within three days postoperatively was not statistically significant between the two groups, the results still had clinical significance. There were no significant differences between the groups in secondary outcomes and safety.
Article
Clinical Neurology
Lei Gao, Peng Li, Nicole Gaykova, Xi Zheng, Chenlu Gao, Jacqueline M. Lane, Richa Saxena, Frank A. J. L. Scheer, Martin K. Rutter, Oluwaseun Akeju, Kun Hu
Summary: This study found a bidirectional link between delirium and dementia, suggesting that they may be mutually related. Furthermore, disturbances in the sleep-wake rhythm were associated with an increased risk of delirium and progression to dementia. These findings highlight the importance of sleep-wake rhythm in cognitive function.
ANNALS OF NEUROLOGY
(2023)
Letter
Anesthesiology
Gonzalo Boncompte, Haoqi Sun, Maria F. Elgueta, Javiera Benavides, Marcela Carrasco, Maria I. Morales, Natalia Caldron, Victor Contreras, M. Brandon Westover, Luis I. Cortinez, Oluwaseun Akeju, Juan C. Pedemonte
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Multidisciplinary Sciences
Fangyun Tian, Laura D. Lewis, David W. Zhou, Gustavo A. Balanza, Angelique C. Paulk, Rina Zelmann, Noam Peled, Daniel Soper, Laura A. Santa Cruz A. Mercado, Robert A. Peterfreund, Linda S. Aglio, Emad N. Eskandar, G. Rees Cosgrove, Ziv M. Williams, R. Mark Richardson, Emery N. Brown, Oluwaseun Akeju, Sydney S. Cash, Patrick L. Purdon
Summary: By analyzing intracranial recordings, the authors found that ketamine engages different brain areas in distinct frequency-dependent patterns, which may be related to its dissociative and antidepressant effects. These findings could have implications for the development of biomarkers and new therapeutics for depression.
NATURE COMMUNICATIONS
(2023)
Letter
Anesthesiology
Kwame Wiredu, Ariel Mueller, Tina B. Mckay, Alkananda Behera, Shahzad Shaefi, Oluwaseun Akeju
Article
Multidisciplinary Sciences
Weihua Ding, Liuyue Yang, Eleanor Shi, Bowon Kim, Sarah Low, Kun Hu, Lei Gao, Ping Chen, Wei Ding, David Borsook, Andrew Luo, Jee Hyun Choi, Changning Wang, Oluwaseun Akeju, Jun Yang, Chongzhao Ran, Kristin L. Schreiber, Jianren Mao, Qian Chen, Guoping Feng, Shiqian Shen
Summary: This study reveals that the level of endocannabinoid signaling in the thalamic reticular nucleus decreases after chronic sleep disruption, leading to increased pain sensitivity. By uncovering this mechanism, a better understanding of the pain issues caused by sleep disruption can be achieved, providing new insights for related treatments and interventions.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Anesthesiology
Isaac Freedman, Andre Dempsey, Mark Hocevar, Oluwaseun Akeju, Timothy Gaulton
ANESTHESIA AND ANALGESIA
(2023)