Intractable epilepsy and the P-glycoprotein hypothesis

Reaction Dynamics of ATP Hydrolysis Catalyzed by P-Glycoprotein

(2014) Michele Scian et al.   BIOCHEMISTRY

Human ABC Transporters at blood-CNS Interfaces as Determinants of CNS Drug Penetration

(2014) Catarina Chaves et al.   CURRENT PHARMACEUTICAL DESIGN

Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs

(2014) NJ Gogtay et al.   Journal of Postgraduate Medicine

In vivo P-glycoprotein function before and after epilepsy surgery

(2014) M. Bauer et al.   NEUROLOGY

Potential role for human P-glycoprotein in the transport of lacosamide

(2013) Chunbo Zhang et al.   EPILEPSIA

Predicting pharmacoresistance in pediatric epilepsy

(2013) Elaine C. Wirrell   EPILEPSIA

Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy

(2013) Uzma Shaheen et al.   EPILEPSY RESEARCH

Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models

(2013) Haruka Nakanishi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy

(2013) Khaled Saad et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Changes in CNS cells in Hyperammonemic portal hypertensive rats

(2013) Silvina Tallis et al.   JOURNAL OF NEUROCHEMISTRY

The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children

(2013) Mehmet Seven et al.   MOLECULAR BIOLOGY REPORTS

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp

(2013) David Dickens et al.   PLoS One

Overcoming multidrug-resistancein vitroandin vivousing the novel P-glycoprotein inhibitor 1416

(2012) Yan Xu et al.   BIOSCIENCE REPORTS

Structural and Functional Properties of Human Multidrug Resistance Protein 1 (MRP1/ABCC1)

(2012) S.-M. He et al.   CURRENT MEDICINAL CHEMISTRY

Evidence-based review on the natural history of the epilepsies

(2012) Dieter Schmidt et al.   CURRENT OPINION IN NEUROLOGY

P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

(2012) Gwen McCaffrey et al.   JOURNAL OF NEUROCHEMISTRY

Association Between Lamotrigine Concentrations and ABCB1 Polymorphisms in Patients With Epilepsy

(2012) Mila Lovrić et al.   THERAPEUTIC DRUG MONITORING

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

(2012) Joost Verbeek et al.   EJNMMI Research

Inhibition by dexmedetomidine of the activation of spinal dorsal horn glias and the intracellular ERK signaling pathway induced by nerve injury

(2011) Ling Liu et al.   BRAIN RESEARCH

In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein

(2011) Chunbo Zhang et al.   EPILEPSIA

Interrater reliability of the international consensus definition of drug-resistant epilepsy: A pilot study

(2011) Xiao-ting Hao et al.   EPILEPSY & BEHAVIOR

Antiepileptic drugs modulate P-glycoproteins in the brain: A mice study with 11C-desmethylloperamide

(2011) Lieselotte Moerman et al.   EPILEPSY RESEARCH

Association ofABCB1gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis

(2011) Batoul Sadat Haerian et al.   PHARMACOGENOMICS

Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled rats

(2010) Xinyue Jing et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulating P-glycoprotein regulation: Future perspectives for pharmacoresistant epilepsies?

(2010) Heidrun Potschka   EPILEPSIA

In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein

(2010) Chunbo Zhang et al.   LIFE SCIENCES

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium–pilocarpine

(2009) Yi Guo et al.   NEUROLOGICAL RESEARCH

The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins

(2009) Carlos Luna-Tortós et al.   PHARMACEUTICAL RESEARCH

Gene-wide tagging study of association betweenABCB1polymorphisms and multidrug resistance in epilepsy in Han Chinese

(2009) Patrick Kwan et al.   PHARMACOGENOMICS

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas 

(2008) ARZU SAGLAM et al.   APMIS

High Levels of P-Glycoprotein Activity in Human Lymphocytes in the First 6 Months of Life

(2008) C Giraud et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The clinical impact of pharmacogenetics on the treatment of epilepsy

(2008) Wolfgang Löscher et al.   EPILEPSIA

Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

(2008) Jens P. Bankstahl et al.   EPILEPSY RESEARCH

Several major antiepileptic drugs are substrates for human P-glycoprotein

(2008) Carlos Luna-Tortós et al.   NEUROPHARMACOLOGY

Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro

(2008) Hui-wen Yang et al.   NEUROSCIENCE LETTERS

Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

(2008) D. S. Miller et al.   PHARMACOLOGICAL REVIEWS

The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood–brain barrier in patients with generalized epilepsy

(2008) Silvio Basic et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA