Review
Health Care Sciences & Services
Giacomo Colletti, Mattia Di Bartolomeo, Sara Negrello, Roy G. Geronemus, Bernard Cohen, Luigi Chiarini, Alexandre Anesi, Raimondo Femino, Ilaria Mariotti, Gregory M. Levitin, Linda Rozell-Shannon, Riccardo Nocini
Summary: This systematic review explores the potential effects of multiple general anesthesia (mGA) procedures on neurodevelopment in patients under 4 years old. The study found that children receiving mGA may be at a greater risk of neurodevelopmental delay. A total of 264,759 unexposed children and 11,027 exposed children were assessed, with significant differences in neurodevelopmental outcomes. Therefore, careful risk/benefit considerations are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Leilei Huang, Yong Zhang
Summary: This systematic review and meta-analysis compared the effects of intravenous anesthetics and inhalation anesthetics on the occurrence of POCD in elderly patients undergoing non-cardiac surgery. The results showed that inhalation anesthesia was comparable to intravenous anesthesia in terms of short-term POCD occurrence, but may cause greater damage to the nervous system.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Chongshan Gu, Lize Wang, Yingjian He, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Tie Fan, Mi Li, Zhaoqing Fan
Summary: This study found that there was no significant difference in recurrence-free survival between local anesthesia and general anesthesia in breast-conserving surgery. However, breast-conserving surgery under local anesthesia was found to be less expensive.
Article
Pharmacology & Pharmacy
Xuyang Nie, Xiaonan Gao, Jinglin Gao, Tianfang Heng, Yuqi Zhang, Yaqi Sun, Zhangying Feng, Li Jia, Mingxia Wang
Summary: The aim of this study was to establish a population pharmacokinetics (PopPK) model of nalbuphine and evaluate the suitability of bodyweight or fixed dosage regimen. The pharmacokinetics of nalbuphine was adequately described by a two-compartment model, with the hourly net fluid volume infused (HNF) identified as a significant covariate. However, the effect of HNF on dosage adjustment was limited. The fixed dosage regimen showed lower PK variability compared to the body weight dosage regimen.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Surgery
Sandeep Bhushan, Xin Huang, Yuanqiong Duan, Zongwei Xiao
Summary: No significant difference was found in the incidence of postoperative cognitive dysfunction after either general or regional anesthesia in elderly patients undergoing hip fracture surgery. Anesthesia choices for hip-fracture surgery may be based on the individual characteristics of each patient rather than anticipated differences in clinical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Anesthesiology
Ya-Ting Du, Ya-Wei Li, Bin-Jiang Zhao, Xiang-Yang Guo, Yi Feng, Ming-Zhang Zuo, Cong Fu, Wei-Jie Zhou, Huai-Jin Li, Ya-Fei Liu, Tong Cheng, Dong-Liang Mu, Yuan Zeng, Peng-Fei Liu, Yan Li, Hai-Yan An, Sai-Nan Zhu, Xue-Ying Li, Hui-Juan Li, Yang-Feng Wu, Dong-Xin Wang, Daniel I. Sessler
Summary: This study showed that in elderly patients undergoing major thoracic and abdominal surgery, combined epidural-general anesthesia with epidural analgesia did not improve overall or cancer-specific long-term mortality, nor did it improve recurrence-free survival. Therefore, the choice between different anesthesia approaches can be made based on patient and clinician preference.
Article
Surgery
Konstantinos Sebekos, Keren Guiab, George Stamelos, Gweniviere Capron, William Brigode, Stathis Poulakidas, Faran Bokhari
Summary: This study compared the outcomes of below-knee amputation (BKA) surgeries performed by general surgeons, orthopedic surgeons, and vascular surgeons. The results showed no significant difference in mortality rates among the three specialties, but patients who had the surgery performed by orthopedic surgeons had fewer complications. Rating: 8/10.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Xianlin Zhu, Min Yang, Junying Mu, Zaiping Wang, Liang Zhang, Hongbai Wang, Fuxia Yan
Summary: This meta-analysis investigated the effect of general anesthesia (GA) vs. regional anesthesia (RA) on the incidence of postoperative delirium (POD) in surgical patients. The results showed that GA was not significantly associated with an increased risk of POD compared to RA.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Mohammad Z. Siddiqui, Muhammad Z. Chauhan, Alvin F. Stewart, Ahmed B. Sallam
Summary: The use of local anesthesia (LA) in VR surgery has been found to significantly reduce anesthesia, surgical, and recovery times, as well as lower costs.
Article
Medicine, General & Internal
Yi-Ting Kao, Chuen-Chau Chang, Chun-Chieh Yeh, Chaur-Jong Hu, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao
Summary: Patients who previously suffered a stroke had increased risks of mortality and complications after surgeries. Comparing the outcomes of stroke patients who received general anesthesia and neuraxial anesthesia, it was found that patients with general anesthesia had higher risks of postoperative complications and mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Laura Hernandez-Hernandez, Catalina Sanz, Elena Marcos-Vadillo, Asuncion Garcia-Sanchez, Esther Moreno, Felix Lorente, David Gonzalez-de-Olano, Ignacio Davila, Maria Isidoro-Garcia
Summary: This study analyzed TPSAB1 mRNA expression and gene dose in a four-member family with high BST, and found that the elevated total BST in the family members correlated with a significant increase in tryptase gene expression and dose.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Nan Zhao, Jie Zeng, Lin Fan, Chao Zhang, YuJia Wu, Xin Wang, Feng Gao, Cong Yu
Summary: The study found that intravenous infusion of alfentanil can reduce the incidence of emergence delirium in children after general anesthesia. The lower dose of 0.2 mu g/kg/min of alfentanil resulted in fewer adverse reactions and shorter discharge delay.
Review
Oncology
Ru Li, Mousumi Beto Mukherjee, Zhaosheng Jin, Hengrui Liu, Kevin Lin, Qiuyue Liu, James P. Dilger, Jun Lin
Summary: This meta-analysis examined the effect of general anesthetics on metastasis and recurrence after cancer surgery. It showed that propofol-based total intravenous anesthesia is associated with a lower risk of metastasis/recurrence and lower IL-6 level compared to inhalational anesthesia. Pre-clinical studies confirmed these findings and explored potential mechanisms.
Article
Biology
George A. Mashour, Ben J. A. Palanca, Mathias Basner, Duan Li, Wei Wang, Stefanie Blain-Moraes, Nan Lin, Kaitlyn Maier, Maxwell Muench, Vijay Tarnal, Giancarlo Vanini, E. Andrew Ochroch, Rosemary Hogg, Marlon Schwartz, Hannah Maybrier, Randall Hardie, Ellen Janke, Goodarz Golmirzaie, Paul Picton, Andrew R. McKinstry-Wu, Michael S. Avidan, Max B. Kelz
Summary: Studying the recovery process of consciousness from unconsciousness in healthy individuals undergoing anesthesia showed that cognitive functions recover over time, with executive function returning first, contrary to initial hypotheses. Early involvement of the prefrontal cortex in recovery is consistent with the global neuronal workspace theory.
Review
Medicine, General & Internal
Alessandro De Cassai, Federico Geraldini, Annalisa Boscolo, Laura Pasin, Tommaso Pettenuzzo, Paolo Persona, Marina Munari, Paolo Navalesi
Summary: Spinal anesthesia in vertebral lumbar surgery can reduce postoperative pain and analgesic requirement, decrease the incidence of postoperative nausea and vomiting, and improve patient satisfaction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Montserrat Fernandez-Rivas, Ismael Gomez Garcia, Alejandro Gonzalo-Fernandez, Manuel Fuentes Ferrer, Sabine Dolle-Bierke, Guadalupe Marco-Martin, Barbara K. Ballmer-Weber, Riccardo Asero, Simona Belohlavkova, Kirsten Beyer, Frederic de Blay, Michael Clausen, Mareen R. Datema, Ruta Dubakiene, Kate E. C. Grimshaw, Karin Hoffmann-Sommergruber, Jonathan O'B Hourihane, Monika Jedrzejczak-Czechowicz, Andre C. Knulst, Tanya Kralimarkova, Thuy-My Le, Nikolaos G. Papadopoulos, Todor A. Popov, Lars K. Poulsen, Ashok Purohit, Suranjith L. Seneviratne, Angela Simpson, Atanasios Sinaniotis, Mirjana Turkalji, Sonia Vazquez-Cortes, Rosialzira N. Vera-Berrios, Antonella Muraro, Margitta Worm, Graham Roberts, Ronald van Ree, Cristina Fernandez-Perez, Paul J. Turner, Elizabeth N. Clare Mills
Summary: The study team developed and validated a severity score for food allergic reactions, with ordinal and numerical formats. Through internal and external validation, the score demonstrated good discrimination, classification, and calibration in emergency situations.
Article
Allergy
Sara Fransson, Jonas Bredtoft Boel, Holger F. Mosbech, Lars K. Poulsen, Samine Ruff, Lene H. Garvey
Summary: This study investigated the rate of severe allergic reactions to direct oral drug provocation in penicillin allergy patients stratified to be at low risk, as well as barriers to penicillin allergy de-labeling and future use of penicillins. The results showed that direct oral provocation without preceding tests was safe in low-risk patients, with no cases of anaphylaxis or severe delayed hypersensitivity. However, benign delayed skin reactions still occurred.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Maria Anna Bruusgaard-Mouritsen, Bettina Margrethe Jensen, Lars K. Poulsen, Jeanne Duus Johansen, Lene Heise Garvey
Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Allergy
Lars H. Blom, Ewa A. Bartko, Thea K. R. Moller, Lars K. Poulsen, Bettina M. Jensen
Letter
Allergy
Ewa A. A. Bartko, Jesper Elberling, Lars K. K. Poulsen, Bettina M. M. Jensen
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Letter
Allergy
Victor Lendal, Sara Fransson, Holger Mosbech, Jonas Bredtoft Boel, Natasha Kahlhofen, Lars H. Blom, Lars K. Poulsen, Lene H. Garvey
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Letter
Allergy
Sara Fransson, Jonas Bredtoft Boel, Anne Holm, Natasha Kahlhofen, Janni Hjortlund, Holger F. Mosbech, Lars K. Poulsen, Susanne Reventlow, Lene H. Garvey
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Sara Fransson, Christina Monnerup Damving, Jonas Bredtoft Boel, Magnus Arpi, Ida Gjorup Skinhoj, Jens Otto Jarlov, Holger F. Mosbech, Lars K. Poulsen, Lene H. Garvey
Summary: This study investigated the proportion of patients with penicillin allergy labels in a Danish hospital and classified them into no risk, low risk, and high-risk categories based on guidelines. The results showed that 10% of inpatients had a penicillin allergy label, and 17% of them could potentially have their label removed without allergy testing.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia de las Vecillas, Rob C. Aalberse, Nathalie Acevedo, Lorenz Aglas, Friedrich Altmann, Karla L. Arruda, Riccardo Asero, Barbara Ballmer-Weber, Domingo Barber, Kirsten Beyer, Tilo Biedermann, Maria Beatrice Bilo, Simon Blank, Philipp P. Bosshard, Heimo Breiteneder, Helen A. Brough, Merima Bublin, Dianne Campbell, Luis Caraballo, Jean Christoph Caubet, Giorgio Celi, Martin D. Chapman, Maksymilian Chruszcz, Adnan Custovic, Rebecca Czolk, Janet Davies, Nikolaos Douladiris, Bernadette Eberlein, Motohiro Ebisawa, Anna Ehlers, Philippe Eigenmann, Gabriele Gadermaier, Mattia Giovannini, Francisca Gomez, Rebecca Grohman, Carole Guillet, Christine Hafner, Robert G. Hamilton, Michael Hauser, Thomas Hawranek, Hans Juergen Hoffmann, Thomas Holzhauser, Tomona Iizuka, Alain Jacquet, Thilo Jakob, Bente Janssen-Weets, Uta Jappe, Marek Jutel, Tanja Kalic, Sandip Kamath, Sabine Kespohl, Joerg Kleine-Tebbe, Edward Knol, Andre Knulst, Jon R. Konradsen, Peter Korosec, Annette Kuehn, Gideon Lack, Thuy-My Le, Andreas Lopata, Olga Luengo, Mika Maekelae, Alessandro Maria Marra, Clare Mills, Martine Morisset, Antonella Muraro, Anna Nowak-Wegrzyn, Roni Nugraha, Markus Ollert, Kati Palosuo, Elide Anna Pastorello, Sarita Ulhas Patil, Thomas Platts-Mills, Anna Pomes, Pascal Poncet, Ekaterina Potapova, Lars K. Poulsen, Christian Radauer, Suzana Radulovic, Monika Raulf, Pierre Rouge, Joaquin Sastre, Sakura Sato, Enrico Scala, Johannes M. Schmid, Peter Schmid-Grendelmeier, Denise Schrama, Helene Senechal, Claudia Traidl-Hoffmann, Marcela Valverde-Monge, Marianne van Hage, Ronald van Ree, Kitty Verhoeckx, Stefan Vieths, Magnus Wickman, Josefina Zakzuk, Paolo M. Matricardi, Karin Hoffmann-Sommergruber
Summary: Since the discovery of IgE as a mediator of allergic diseases, our knowledge about its immunological mechanisms has greatly increased. Innovations in bioscience and technology have facilitated the production of well-defined molecules for component-resolved diagnosis, allowing personalized management of allergic diseases. The Molecular Allergology User's Guide 2.0 provides updated information on allergen molecules, their clinical relevance, and diagnostic algorithms, serving as a valuable resource for clinicians and scientists.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ewa A. Bartko, Lars H. Blom, Jesper Elberling, Lars K. Poulsen, Bettina M. Jensen
Summary: Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). In this study, the basophil homing potential and receptor profile of CU were investigated. It was found that unstimulated basophils in CU showed higher expression of skin-associated and scavenger receptors, and lower expression of the lung-associated receptor compared to healthy basophils. IgE-mediated activation increased the expression of certain receptors and amplified the skin-homing potential of CU basophils.
Article
Allergy
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Juergen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
Summary: This guideline from the European Academy of Allergy and Clinical Immunology provides recommendations for diagnosing IgE-mediated food allergy, including clinical history, tests for determining IgE sensitization, and the use of oral food challenges for confirmation.
Article
Allergy
Lars H. Blom, Lasse B. Schmidt, Claus R. Johnsen, Jesper Elberling, Lars K. Poulsen, Lene H. Garvey
Article
Allergy
J. H. Akkerdaas, A. Cianferoni, E. Islamovic, J. Kough, G. S. Ladics, S. McClain, L. K. Poulsen, A. Silvanovich, L. Pereira Mouries, R. van Ree
Summary: This study evaluates the impact of experimental and endogenous food matrices on the susceptibility of homologous proteins with different degrees of allergenicity to proteases. The results demonstrate that protein-rich food matrices delay pepsin digestion but do not help in understanding the differences in allergenicity between homologous proteins.
FRONTIERS IN ALLERGY
(2022)
Article
Allergy
Peter Stoffersen, Per S. Skov, Lars K. Poulsen, Bettina M. Jensen
Summary: The study investigated the concentration of sIgE required for successful passive sensitization using birch pollen allergy as a model. The results demonstrate that the IgE titer is strikingly robust in predicting the ability to sensitize basophils and produce a measurable histamine release.
FRONTIERS IN ALLERGY
(2022)
Article
Allergy
Nanna Juel-Berg, Lau Fabricius Larsen, Niels Kuechen, Ida Norgil, Kirsten Skamstrup Hansen, Lars K. Poulsen
Summary: The study found that in Denmark, clinically relevant tree nut allergy is generally associated with allergies to two or more tree nuts, with close to half of the subjects also allergic to peanuts. There are two distinct allergic phenotypes, with most hazelnut allergic subjects also allergic to walnut, and all but one subject with cashew allergy being dual allergic to pistachio. These findings are supported by strong sIgE correlations between hazelnut and walnut, and close to total sIgE correlation between cashew and pistachio.
FRONTIERS IN ALLERGY
(2022)