Article
Neurosciences
Francesco Bove, Francesco Cavallieri, Anna Castrioto, Sara Meoni, Emmanuelle Schmitt, Amelie Bichon, Eugenie Lhommee, Pierre Pelissier, Andrea Kistner, Eric Chevrier, Eric Seigneuret, Stephan Chabardes, Franco Valzania, Valerie Fraix, Elena Moro
Summary: Research on patients with Parkinson's disease (PD) shows that the side of motor symptom onset does not significantly affect the outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS).
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Carlo Alberto Artusi, Claudia Ledda, Domiziana Rinaldi, Elisa Montanaro, Alberto Romagnolo, Gabriele Imbalzano, Mario Giorgio Rizzone, Maurizio Zibetti, Leonardo Lopiano, Marco Bozzali
Summary: The study highlights the importance of axial symptoms and response to levodopa in predicting the therapeutic effect of deep brain stimulation (DBS) in Parkinson's disease (PD) patients, with disease duration also playing a significant role.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Zahra Eghlidos, Zahra Rahimian, Gholamreza Vadiee, Soodeh Jahangiri
Summary: This meta-analysis examines the effect of deep brain stimulation (DBS) on non-motor symptoms (NMS) in Parkinson's disease (PD) patients. The results indicate that bilateral subthalamic nucleus DBS significantly reduces total NMS scores, as well as scores in various NMS domains such as sleep, miscellaneous symptoms, urinary problems, sexual dysfunction, and attention/memory issues.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Feng Zhang, Feng Wang, Weiguo Li, Ning Wang, Chunlei Han, Shiying Fan, Peng Li, Lifeng Xu, Jianguo Zhang, Fangang Meng
Summary: STN-DBS can improve motor symptoms and quality of life in PD patients. The closer the stimulation is to the STN dorsolateral sensorimotor area, the higher the DBS is to improve motor symptoms in PD patients.
Article
Clinical Neurology
Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
Summary: Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. The UPDRS part I score and higher impulsivity might be associated with QOL after STN-DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Martina Bockova, Eva Vytvarova, Martin Lamos, Petr Klimes, Pavel Jurak, Josef Halamek, Sabina Goldemundova, Marek Balaz, Ivan Rektor
Summary: The response to subthalamic nucleus deep brain stimulation (STN-DBS) varies individually and is difficult to predict. While most patients did not show changes in global network organization, suboptimal responders exhibited decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas. The supplementary motor area was demonstrated to play an important role in the optimal response to DBS, with good responders showing increased node strength and eigenvector centrality in this brain region.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)