Article
Neurosciences
Yinghui Li, Yingying Yue, Suzhen Chen, Wenhao Jiang, Zhi Xu, Gang Chen, Zixin Zhu, Liangliang Tan, Yonggui Yuan
Summary: This study found that anhedonic major depressive disorder (MDD) patients have higher serum levels of cytokines and cortisol, and a combination of IL-6, CRP, and cortisol can serve as an early marker for distinguishing anhedonic MDD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Wei Zheng, Li-Mei Gu, Chen-Hui Sun, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Yu-Ping Ning
Summary: This study found that repeated ketamine infusions appeared to be effective at rapidly ameliorating anhedonia in Chinese individuals suffering from MDD and BD, with similar efficacy between the two groups.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Simona Scheggi, Graziano Pinna, Giulia Braccagni, Maria Graziella De Montis, Carla Gambarana
Summary: Peroxisome proliferator-activator receptors (PPARs) play a role in regulating lipid and glucose metabolism, controlling inflammatory processes, and modulating various brain functions. Among them, PPAR gamma is particularly important in neuropsychiatric and neurodegenerative disorders, with its localization in neuronal circuits involved in emotion modulation and stress response, as well as its role in neurodevelopment and neuroinflammation. Future clinical trials should evaluate the efficacy of PPAR gamma agonists in the treatment of mood and neurodevelopmental disorders such as depression, schizophrenia, and ASD, based on robust preclinical evidence and initial results of clinical studies.
Article
Behavioral Sciences
Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A. Slattery, Yurdaguel Zopf, Stephanie L. Borgland, Andreas Reif, Sharmili Edwin Thanarajah
Summary: Type 2 diabetes and major depressive disorder (MDD) are highly comorbid and leading causes of disability. This review discusses the potential molecular mechanisms underlying their association by examining the effects of insulin on dopaminergic signaling and behavior in the brain. It also explores the impact of insulin resistance on depressive symptoms and anhedonia, and its relevance for treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Montse Flores-Garcia, Arianna Rizzo, Maria Zelai Garcon-Poca, Victor Fernandez-Duenas, Jordi Bonaventura
Summary: Chronic pain and depression lead to a significant socioeconomic burden. This review focuses on the role of the ventral tegmental area (VTA) as a hub where pain and emotional processing converge, and discusses the feasibility of using VTA as a therapeutic target. The dopaminergic system and VTA have been extensively studied in mood disorders, but less attention has been given to their involvement in pain and mood-related consequences.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Clinical Neurology
Henrik Heitmann, Till F. M. Andlauer, Thomas Korn, Mark Muhlau, Peter Henningsen, Bernhard Hemmer, Markus Ploner
Summary: Fatigue, depression, and pain are common symptoms in multiple sclerosis (MS) patients, with recent neuroimaging and neuroimmunological findings suggesting that dysfunctional reward processing may represent a shared mechanism for these symptoms. Therapeutic focus on monoaminergic neurotransmission is key, but current treatments have limitations in addressing these symptoms effectively.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Chuanzhen Zhao, Kevin M. Cheung, I-Wen Huang, Hongyan Yang, Nako Nakatsuka, Wenfei Liu, Yan Cao, Tianxing Man, Paul S. Weiss, Harold G. Monbouquette, Anne M. Andrews
Summary: Implantable aptamer-field-effect transistor (FET) neuroprobes were developed for monitoring neurotransmitters, enabling femtomolar serotonin detection limits in brain tissue. This study opens opportunities for integrated neural activity recordings at high spatiotemporal resolution by combining these aptamer-FET sensors with other types of Si-based implantable probes.
Article
Neurosciences
Hiroki Kawashima, Yuri Aono, Yuriko Watanabe, John L. Waddington, Tadashi Saigusa
Summary: This study demonstrates that accumbal OX2 receptors, not OX1 receptors, inhibit basal dopamine efflux, while blocking OX2 receptors increases dopamine efflux. OX1 receptors have no effect on dopamine efflux.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Summary: In this study, researchers found that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behavior in mice.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Juanjuan Ren, Zhiguo Wu, Daihui Peng, Jia Huang, Weiping Xia, Jingjing Xu, Chenglei Wang, Lvchun Cui, Yiru Fang, Chen Zhang
Summary: This study investigated the differences in anhedonia and its cognitive correlates between first episode of depression (FED) and recurrent depression (RD). The results showed that RD patients had more severe symptoms of anhedonia and cognitive impairment compared to FED patients. There was a significant correlation between cognitive symptoms and anhedonia, and different medications had different effects on cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt
Summary: This study used a rat model of PTSD to investigate the effects of stress on monoamine concentrations in brain regions associated with PTSD in female rats. The findings indicate that stress exposure can lead to long-term alterations in monoamine function in female rats, suggesting potential interventions using MAOIs as a treatment for PTSD in women.
Article
Clinical Neurology
Qi Liu, Benjamin A. Ely, Joshua J. Schwartz, Carmen M. Alonso, Emily R. Stern, Vilma Gabbay
Summary: This study found that lack of pleasure (anhedonia) in adolescent patients with depression may be a predictor of future depression and suicidal ideation. Specifically, activation in the left angular gyrus was associated with future depression, while activation in key salience and pain network regions was associated with future anhedonia.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Wei Tang, Hongyang Liu, Lixian Chen, Ke Zhao, Yaoyao Zhang, Ke Zheng, Cheng Zhu, Tiansheng Zheng, Jiahong Liu, Dandan Wang, Lingfang Yu, Xinyu Fang, Chen Zhang, Kuan-Pin Su
Summary: The study revealed that patients with anhedonia in major depressive disorder exhibit different inflammatory characteristics compared to patients without anhedonia. Elevated plasma CFH levels may serve as a potential biomarker for anhedonia in subtyping MDD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Joseph R. Cohen, Hena Thakur
Summary: The study explored the variation of adolescent depressive symptoms, depressed mood, and anhedonia across intersecting identities over time. The findings suggest that the impact of identity on depression outcomes is tenfold that of temporal effects, and certain groups, such as multiracial, late adolescent, and female adolescents, are particularly vulnerable to depression. Limitations include the exclusion of certain facets of identity and the use of a unidimensional measure of poverty.
JOURNAL OF AFFECTIVE DISORDERS
(2022)