Article
Emergency Medicine
Amy M. DeLaroche, Fabrice I. Mowbray, Maryam Bohsaghcheghazel, Kristina Zalewski, Katherine Obudzinski
Summary: Early administration of IV Mg was associated with more timely delivery of first-line asthma therapies, such as bronchodilators and systemic corticosteroids. Factors associated with early administration of IV Mg included hypoxia, respiratory rate, retractions, and prior hospital use for asthma-related complaints.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ashir Mehra, Francisco Gomez, Holly Bischof, Daniel Diedrich, Krzysztof Laudanski
Summary: Poor outcomes in Subarachnoid Hemorrhage (SAH) can be attributed to Delayed Cerebral Ischemia (DCI), a unique form of secondary neurological injury. DCI is characterized by new neurological insults that occur beyond 72 hours after the hemorrhage, even without radiographic evidence of vasospasm. Recent evidence suggests that Cortical Spreading Depolarizations (CSDs) may be responsible for DCI, triggering neuroinflammation, microthrombi formation, and vasoconstriction. Ketamine and Nimodipine show promise in treating and preventing CSDs, but further research is needed to determine their therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Claudia Desole, Simona Gallo, Annapia Vitacolonna, Francesca Montarolo, Antonio Bertolotto, Denis Vivien, Paolo Comoglio, Tiziana Crepaldi
Summary: HGF and its receptor MET play crucial roles in the nervous system, not only involved in neuronal growth and survival, but also in synaptogenesis during brain development. Furthermore, HGF exerts neuroprotective effects in adulthood, aiding in the treatment of neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Longfei Wu, Haiqing Song, Chi Zhang, Anxin Wang, Bowei Zhang, Chiyu Xiong, Xianbo Zhuang, Yingzhuo Zang, Chenghao Li, Qi Fang, Chuanqiang Qu, Lihua Wang, Mei Zhang, Hao Li, Xiaoli Wang, Yanan Li, Lei Xia, Zhigang Yao, Zhi Nie, Ying Gao, Xunming Ji
Summary: This study evaluated the efficacy and safety of Xuesaitong soft capsules in patients with ischemic stroke through a multicenter, double-blind, placebo-controlled randomized clinical trial. The results showed that compared with the control group, Xuesaitong soft capsules significantly increased functional independence at 3 months and had good safety. Therefore, Xuesaitong soft capsules may be a safe and effective alternative therapy to improve prognosis in patients with ischemic stroke.
Article
Medicine, General & Internal
Serhat Imamoglu, Ebru Yalin Imamoglu, Serkan Erdenoz, Alev Cumbul, Unal Uslu, Samil AktaS, Fahri Ovali
Summary: The study showed that magnesium sulfate could reduce apoptosis, preserve RGCs, and decrease retinal VEGFR-2 and GFAP expressions in a preterm hypoxic-ischemic rat model.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Integrative & Complementary Medicine
Xiao-Hong Ba, Xiao-Di Wang, Yong-Yi Dai
Summary: This study supports the beneficial effect of magnesium in reducing the risk of delayed cerebral ischemia and found that immediate intracranial magnesium therapy combined with intravenous hydrogen treatment after subarachnoid hemorrhage can increase the rate of good recovery. Further high-quality studies are needed to confirm this finding.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: The study found that Tat-p27 can inhibit neuronal damage by reducing oxidative stress, alpha-synuclein expression, and inflammatory responses.
NEUROCHEMICAL RESEARCH
(2021)
Article
Microbiology
Xiao Lan, Jie Zhang, Zaifeng Wang, Ruiyong Zhang, Wolfgang Sand, Liang Zhang, Jizhou Duan, Qingjun Zhu, Baorong Hou
Summary: The study investigates the accelerated corrosion of magnesium alloys in a mudflat environment, where a strain of sulfate-reducing prokaryote (SRP) was found to increase the corrosion rate. Pitting occurred in both biotic and abiotic systems.
Article
Clinical Neurology
Alexander Perdomo-Pantoja, Hesham Mostafa Zakaria, Ann Liu, Yohannes Tsehay, Carly Weber-Levine, Gordon Mao, Nicholas Theodore
Summary: This study presented a case of vascular myelopathy secondary to the occlusion of the Adamkiewicz artery by an intrathecal catheter, which resolved after decompression. Meticulous, multidisciplinary neurological and radiological evaluations were essential in diagnosing and treating the patient's condition. Despite being exceedingly rare, direct compression of the Adamkiewicz artery by an intrathecal catheter should be considered in the evaluation of vascular myelopathy causes.
OPERATIVE NEUROSURGERY
(2022)
Article
Clinical Neurology
Ofer Sadan, Hannah Waddel, Renee Moore, Chen Feng, Yajun Mei, David Pearce, Jacqueline Kraft, Cederic Pimentel, Subin Mathew, Feras Akbik, Pouya Ameli, Alexis Taylor, Lisa Danyluk, Kathleen S. Martin, Krista Garner, Jennifer Kolenda, Amit Pujari, William Asbury, Blessing N. R. Jaja, R. Loch Macdonald, C. Michael Cawley, Daniel L. Barrow, Owen Samuels
Summary: This study describes the experience of using intrathecal nicardipine in patients with subarachnoid hemorrhage. Compared to untreated patients, the treated group had a lower rate of delayed cerebral ischemia, improved functional outcome, but higher rates of ventriculoperitoneal shunting.
JOURNAL OF NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Ping-Heng Tan, Jasmine Ji, Chung-Hsi Hsing, Radika Tan, Ru-Rong Ji
Summary: Type I interferons (IFNs) play a crucial role in the nervous system, exhibiting antiviral activity and regulating cognition, neuronal activity, and pain. The interaction between neuroinflammation and neuro-glial cells significantly influences the effects of type I IFNs. Understanding the signaling of type I IFNs in neurons and non-neuronal cells can improve the treatment of neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Shijie Lv, Kunchi Zhao, Ran Li, Chunyang Meng, Guangchun Li, Fei Yin
Summary: This study used RNA-Seq high-throughput sequencing and bioinformatics analysis to investigate the molecular mechanisms underlying spinal cord ischemia-reperfusion (SCI/R) injury. EGFR was found to be downregulated in the spinal cord of SCI/R mice and may function via mediating the JAK2/STAT3 signaling pathway. In vitro and in vivo experiments confirmed that EGFR inhibits SCI/R-induced neuronal apoptosis by activating the JAK2/STAT3 signaling pathway, thus improving spinal cord injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dan Fu, Cai Chen, Liang He, Jingjuan Li, Aiguo Li
Summary: Mild hypothermia attenuates spinal cord ischemia-induced injury and inflammation by inhibiting the TLR4/NF-κB pathway and promoting microglial M2 polarization.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Yasuhiro Itoh, Vibhu Sahni, Sara J. Shnider, Holly McKee, Jeffrey D. Macklis
Summary: How CNS circuits form spatially and functionally organized domains is not well understood. The segmental specificity of corticospinal connectivity exemplifies the regional specificity of axon projections. Multiple molecularly distinct subpopulations of corticospinal neurons innervate the cervical cord for enhanced precision of forelimb movement.
Article
Cell & Tissue Engineering
Kaveena Autar, Xiufang Guo, John W. Rumsey, Christopher J. Long, Nesar Akanda, Max Jackson, Narasimhan S. Narasimhan, Julbert Caneus, Dave Morgan, James J. Hickman
Summary: This study developed a phenotypic model of hiPSC-derived cortical neurons and characterized their maturation process using various analysis methods. It also demonstrated the potential application of this model in disease modeling.
Review
Endocrinology & Metabolism
Seungyup Sun, Nicklaus H. Diggins, Zachary J. Gunderson, Jill C. Fehrenbacher, Fletcher A. White, Melissa A. Kacena
Review
Endocrinology & Metabolism
Luke G. McVeigh, Anthony J. Perugini, Jill C. Fehrenbacher, Fletcher A. White, Melissa A. Kacena
CURRENT OSTEOPOROSIS REPORTS
(2020)
Editorial Material
Medicine, General & Internal
Melissa A. Kacena, Fletcher A. White
Review
Cell Biology
Xingjuan Chen, Gagandeep Sooch, Isaac S. Demaree, Fletcher A. White, Alexander G. Obukhov
Article
Clinical Neurology
Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman, Fletcher A. White
JOURNAL OF HEADACHE AND PAIN
(2020)
Editorial Material
Cell Biology
Priya R. Kirtley, Gagandeep S. Sooch, Fletcher A. White, Alexander G. Obukhov
Article
Oncology
Tatsuo Okui, Masahiro Hiasa, Shoji Ryumon, Kisho Ono, Yuki Kunisada, Soichiro Ibaragi, Akira Sasaki, G. David Roodman, Fletcher A. White, Toshiyuki Yoneda
Summary: Bone pain caused by breast cancer metastasis is a common complication and a major factor in increased mortality. Studies suggest that HMGB1 secreted by breast cancer cells induces BCABP through binding to RAGE on sensory neurons.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Clinical Neurology
Xingjie Ping, Zhi Chai, Weiping Wang, Cungen Ma, Fletcher F. A. White, Xiaoming Jin
Summary: Blocking RAGE and TLR4 signaling pathways significantly increased seizure threshold, reduced spontaneous seizure events, increased neuronal and inhibitory interneuron densities in the lesioned cortex, and decreased astrocyte and microglia densities in the treatment groups, suggesting a potential strategy for preventing posttraumatic epilepsy.
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Review
Clinical Neurology
Andreea Radulescu, Fletcher A. White, Chantal Chenu
Summary: Progress has been made in bone fracture repair research, but pain scoring and management in rodent fracture models remain challenging. Animal models for fracture pain provide a quantitative evaluation and study of new therapeutic approaches.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Eun Jin Ahn, Fletcher A. White, Ye Jin Cho, Chong Wha Baek, Yong Hun Jung, Ji Wung Kwon
Summary: This study evaluated the efficacy of immature Rubus occidentalis extract (iROE) on acid-induced hyperalgesia and investigated the mechanism involved. The antihyperalgesic effect of immature and mature ROEs was compared.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Neurosciences
Kelly M. Naugle, Sam Corrona, Jared A. Smith, Tyler Nguyen, Jonathan Saxe, Fletcher A. White
Summary: Lower levels of physical activity in the first month after mild TBI predict decreased conditioned pain modulation and greater pain catastrophizing in patients with mild TBI. Conversely, greater self-reported physical activity, especially moderate PA, 1 to 2 weeks after injury, predicted better pain inhibitory capacity on the CPM test at 1 month after injury in patients with mTBI. Additionally, greater sedentary behavior was associated with worse pain inhibition on the CPM test and greater pain catastrophizing at 1 month after injury.
Review
Medicine, General & Internal
Hyun Jin Min, Kyung Soo Kim, Geun Joo Choi, Hyun Kang, Fletcher A. White
Summary: The study aimed to evaluate the concentrations of high-mobility group box 1 and heat-shock protein 70 in the upper and lower airways of healthy individuals through meta-analysis. Results showed significant heterogeneity in the concentrations of these proteins in different airway locations and age groups. Heat-shock protein 70 had significantly higher concentrations in the upper airway compared to the lower airway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Yohance Allette, Youngsook Kim, Jared Smith, Matthew Ripsch, Fletcher White
Meeting Abstract
Endocrinology & Metabolism
Melissa Kacena, Zachary Gunderson, Aamir Tucker, Natalie Taylor-Nguyen, Peter Malicky, Rachel Blosser, Fletcher White
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)