Article
Geriatrics & Gerontology
Elena Kainz, Neelke Juilfs, Ulrich Harler, Ursula Kahl, Caspar Mewes, Christian Zoellner, Marlene Fischer
Summary: This study aimed to investigate the association between cognitive reserve and delayed neurocognitive recovery in the early postoperative period. The findings suggest that higher cognitive reserve in elderly patients undergoing major non-cardiac surgery reduces the risk of subsequent delayed neurocognitive recovery in the early postoperative period.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Delin Zhang, Yi Shen, Zhiyun Chen, Yang Guo, Zaifeng Gao, Jian Huang, Xiqian Lu
Summary: Cognitive dysfunction after anesthesia and surgery has long been recognized. Recent empirical evidence shows that patients may experience social cognition dysfunction (SCD), particularly deficits in emotion recognition, following cardiac surgery. This study focused on examining patients' abilities of biological motion (BM) emotion perception and action perception before and after anesthesia and surgery. Results revealed that while action perception remained intact after cardiac surgery, 18.3% of patients exhibited deficits in emotion perception, further confirming the existence of SCD after anesthesia and surgery.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Catherine M. Wagner, Melissa J. Clark, Patricia F. Theurer, Shelly C. Lall, Hassan W. Nemeh, Richard S. Downey, David E. Martin, Reza R. Dabir, Zewditu E. Asfaw, Phillip L. Robinson, Steven D. Harrington, Divyakant B. Gandhi, Jennifer F. Waljee, Michael J. Englesbe, Chad M. Brummett, Richard L. Prager, Donald S. Likosky, Karen M. Kim, Kiran H. Lagisetty, Alexander A. Brescia
Summary: Discharging select patients without an opioid prescription after cardiac surgery appears to be well tolerated, with a low incidence of postdischarge opioid prescriptions.
ANNALS OF THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Tracey Bowden, Catherine S. Hurt, Julie Sanders, Leanne M. Aitken
Summary: This systematic review aimed to identify preoperative and postoperative predictors of cognitive dysfunction in adults following cardiac surgery. The results suggest that age and education level significantly impact cognitive outcome, indicating that older patients and those with lower educational levels should be prioritized for interventions to improve cognitive function. Further high-quality research exploring predictors of postoperative cognitive dysfunction is needed.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Surgery
Tomokazu Kishiki, Hiroshi Hasegawa, Hideaki Yoshino, Nobuyoshi Aso, Aiko Iioka, Takashi Wakamatsu, Kazuna Honda, Isao Kataoka, Sangchul Kim, Shun Ishii, Satoshi Isobe, Toshiya Shirota, Mayumi Ide, Seiichi Taniai, Kumi Moriyama, Tomoko Yorozu, Haruhiko Kondo, Yoshihiro Sakamoto, Nobutsugu Abe, Eiji Sunami
Summary: Frailty factors, including physical frailty and mental and cognitive functions, change after non-cardiac surgery in older adults.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Emanuela Bianciardi, Giulia Raimondi, Tonia Samela, Marco Innamorati, Lorenzo Maria Contini, Leonardo Procenesi, Mariantonietta Fabbricatore, Claudio Imperatori, Paolo Gentileschi
Summary: This study aimed to investigate neurocognitive and psychopathological predictors of surgical efficacy in terms of weight loss, with findings suggesting that pre-operative binge eating symptoms are associated with lower weight loss four years post-surgery. Ongoing clinical monitoring and interventions may be necessary for affected patients, highlighting the importance of neuropsychological assessment in bariatric surgery candidates for tailored rehabilitative interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Feng Xu, Qingtong Zhang, Dongsheng Xuan, Shuai Zhao, Yafeng Wang, Linlin Han, Shiqian Huang, Hongyu Zhu, Tingting Wang, Xiangdong Chen
Summary: This study found that daytime variation may affect recovery after general anesthesia, and afternoon surgery may provide better protection compared to morning surgery.
ANNALS OF MEDICINE
(2023)
Article
Surgery
Yangzi Zhu, Meiyan Zhou, Xiuqin Jia, Wei Zhang, Yibing Shi, Shengjie Bai, Sanketh Rampes, Marcela P. Vizcaychipi, Congyou Wu, Kai Wang, Daqing Ma, Qi Yang, Liwei Wang
Summary: The goal of this study was to investigate the changes in functional connectivity (FC) after cardiac surgery and its relationship with cognitive deficits and systemic inflammation. Seventeen patients who underwent cardiac valve replacement and age-matched healthy controls were included in the study. Results showed that executive function was significantly impaired after cardiac surgery. The surgical patients demonstrated decreased FC within the executive control network and attenuated negative connectivity in the default mode network, which were related to increased tumor necrosis factor-a levels and decreased executive function up to day 7 after surgery.
Article
Anesthesiology
Hassan Hamadnalla, Daniel I. Sessler, Christopher A. Troianos, Jonathan Fang, Eva Rivas, Chao Ma, Edward J. Mascha, Alparslan Turan
Summary: The study aimed to determine when postoperative delirium first occurs and to assess evaluation strategies with lowest frequency of testing. Postoperative delirium is common among patients undergoing elective coronary artery bypass and/or valve surgery. Delirium is most often detected in the mornings, with the majority of cases identified by the end of the first postoperative day. Evaluating patients twice daily for four days can detect almost all delirium cases, making it a sufficient approach for clinical and research purposes.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Nathalie Roy, M. Fernanda Parra, Morgan L. Brown, Lynn A. Sleeper, Laura Carlson, Barbara Rhodes, Meena Nathan, Kshitij P. Mistry, Pedro J. del Nido
Summary: This study evaluated the adherence and outcomes of a comprehensive enhanced recovery program in congenital cardiac surgery. The results showed that patients following the program had reduced opioid use, increased rates of extubation in the operating room, and shorter mechanical ventilation durations.
ANNALS OF THORACIC SURGERY
(2022)
Article
Anesthesiology
Paul Michel Mertes, Michel Kindo, Julien Amour, Christophe Baufreton, Lionel Camilleri, Thierry Caus, Didier Chatel, Bernard Cholley, Alain Curtil, Jean-Philippe Grimaud, Remi Houel, Fehmi Kattou, Jean-Luc Fellahi, Catherine Guidon, Pierre Gregoire Guinot, Guillaume Lebreton, Sandrine Marguerite, Alexandre Ouattara, Sophie Provenchere Fruithiot, Bertrand Rozec, Jean-Philippe Verhove, Andre Vincentelli, Helene Charbonneau
Summary: This study provides recommendations for Enhanced Recovery After Cardiac Surgery (ERACS) using a multimodal approach of perioperative medicine. The aim is to improve patient satisfaction, reduce postoperative mortality and morbidity, and decrease length of hospital stays. 33 recommendations were agreed upon by a panel of experts, based on extensive research and analysis.
ANESTHESIE & REANIMATION
(2022)
Review
Medicine, General & Internal
Caroline Tresch, Marine Lallemant, Rajeev Ramanah
Summary: This study aimed to review the influence of enhanced rehabilitation on outcomes of pelvic organ prolapse surgery. The findings showed no significant difference in operating time, complications, blood loss, and pain scores before and after the adoption of the enhanced recovery after surgery (ERAS) program. However, there was a noticeable decrease in intravenous intakes, opioid administration, length of stay, and overall hospital costs with the adoption of ERAS. Patients were also able to mobilize more rapidly and reported higher satisfaction levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anoop N. Koshy, Davide Cao, Matthew A. Levin, Samantha Sartori, Gennaro Giustino, Htoo Kyaw, Bimmer Claessen, Zhongjie Zhang, Johny Nicolas, Anton Camaj, Anastasios Roumeliotis, Rishi Chandiramani, Rashi Bedekar, Zaha Waseem, Shiv Bagga, Annapoorna Kini, Samin K. Sharma, Roxana Mehran
Summary: This study aimed to identify predictors of antiplatelet therapy cessation in patients undergoing noncardiac surgery following percutaneous coronary intervention (PCI). Multiple patient and surgery-related risk factors influenced the decision on stopping antiplatelet therapy. These findings highlight the importance of individualized decision-making.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cindy Y. Teng, Sara Myers, Tanya S. Kenkre, Luke Doney, Wai Lok Tsang, Kathirvel Subramaniam, Stephen A. Esper, Jennifer Holder-Murray
Summary: Postoperative ileus is a common complication following colorectal surgery under Enhanced Recovery Protocols. Patients with pre-existing psychiatric comorbidities and preoperative antipsychotic use may be at increased risk for postoperative ileus, highlighting the need for additional research and preoperative interventions to reduce postoperative ileus in this higher-risk population.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Medicine, General & Internal
Joshua G. Kovoor, Brandon Stretton, Jonathan Henry W. Jacobsen, Aashray K. Gupta, Christopher D. Ovenden, Joseph N. Hewitt, John M. Glynatsis, Suzanne Edwards, Kaitryn Campbell, Gayatri P. Asokan, David R. Tivey, Wendy J. Babidge, Christopher K. Rayner, Adrian A. Anthony, Markus Trochsler, Michael Horowitz, Peter J. Hewett, Karen L. Jones, Guy J. Maddern
Summary: This study aims to characterize the duration of postoperative gastrointestinal recovery across all surgical procedures and determine the associations between factors that may affect this. The outcomes will be disseminated through publication in scientific journals and presentations at conferences.
Article
Anesthesiology
Camilo Toro, Sonia Jain, Shelly Sun, Nancy Temkin, Jason Barber, Geoffrey M. Manley, Jordan M. Komisarow, Tetsu Ohnuma, Brandon Foreman, Frederick L. Korley, Michael L. James, Daniel S. Laskowitz, Monica S. Vavilala, Adrian P. Hernandez, Joseph P. J. Mathew, Amy J. Markowitz, Vijay Krishnamoorthy
Summary: This retrospective cohort study assessed the impact of brain injury biomarkers on the risk of circulatory shock in patients with moderate-severe traumatic brain injury. The study found an association between the levels of neuronal injury biomarkers and the development of circulatory shock. The results suggest that neuronal injury biomarkers may provide early identification of patients at risk for early circulatory shock following TBI.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Maham F. Karatela, Marat Fudim, Joseph P. Mathew, Jonathan P. Piccini
Summary: Atrial fibrillation is influenced by both sympathetic and parasympathetic influences through cardiac autonomic innervation. Innovative therapies targeting the neurocardiac axis, such as catheter ablation or pharmacologic suppression of ganglionated plexi, renal sympathetic denervation, low-level vagal stimulation, and stellate ganglion blockade, have variable efficacy. Improving our understanding of atrial fibrillation and the cardiac nervous system will lead to further advancements in therapeutic neuromodulation for the benefit of patients with AF.
Article
Gastroenterology & Hepatology
Naga Chalasani, Yi-Ju Li, Andrew Dellinger, Victor Navarro, Herbert Bonkovsky, Robert J. Fontana, Jiezhun Gu, Huiman Barnhart, Elizabeth Phillips, Craig Lammert, Tae-Hwi Schwantes-An, Paola Nicoletti, David E. Kleiner, Jay H. Hoofnagle
Summary: This study describes the clinical characteristics, outcomes, and HLA risk factors for nitrofurantoin-induced liver injury (NTF-DILI) among individuals enrolled in the Drug Induced Liver Injury Network (DILIN). Long-term use of NTF can result in parenchymal necrosis, bridging fibrosis, cirrhosis, and death or liver transplantation, and is associated with HLA-DRB1*11:04. Regulators should revise the prescribing information and consider other mitigation strategies.
JOURNAL OF HEPATOLOGY
(2023)
Article
Clinical Neurology
Yi Ju Li, Karen Nuytemans, Jong Ok La, Rong Jiang, Susan H. Slifer, Shuming Sun, Adam Naj, Xiaoyi Raymond Gao, Eden R. Martin
ALZHEIMERS & DEMENTIA
(2023)
Article
Gastroenterology & Hepatology
Paola Nicoletti, Andrew Dellinger, Yi Ju Li, Huiman X. Barnhart, Naga Chalasani, Robert J. Fontana, Joseph A. Odin, Jose Serrano, Andrew Stolz, Amy S. Etheridge, Federico Innocenti, Olivier Govaere, Jane I. Grove, Camilla Stephens, Guruprasad P. Aithal, Raul J. Andrade, Einar S. Bjornsson, Ann K. Daly, M. Isabel Lucena, Paul B. Watkins
Summary: In this study, the researchers found new genetic risk factors for amoxicillin-clavulanate-induced liver injury (AC-DILI) and developed a genetic risk score (GRS) to assess the likelihood of AC-DILI occurrence. The study identified low expression of ERAP2 and the presence of HLA-B*15:18 as novel risk factors for AC-DILI.
Article
Multidisciplinary Sciences
Xiaoyi Raymond Gao, Marion Chiariglione, Ke Qin, Karen Nuytemans, Douglas W. Scharre, Yi-Ju Li, Eden R. Martin
Summary: By constructing polygenic risk scores (PRSs) and using machine learning models, this study predicts the development of Alzheimer's disease (AD) and explores the importance of PRSs, conventional risk factors, and ICD-10 codes. The PRSs are found to be more important predictors than age for late-onset AD. The machine learning model also identifies important predictors from electronic health records, such as urinary tract infection, syncope and collapse, chest pain, disorientation, and hypercholesterolemia.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Jordan Hatfield, Tetsu Ohnuma, Alexandria L. Soto, Jordan M. Komisarow, Monica S. Vavilala, Daniel T. Laskowitz, Michael L. James, Joseph P. Mathew, Adrian F. Hernandez, Benjamin A. Goldstein, Miriam Treggiari, Karthik Raghunathan, Vijay Krishnamoorthy
Summary: This retrospective cohort study aimed to describe the utilization patterns and clinical outcomes of ECMO in patients with TBI. The study found that ECMO utilization in mechanically ventilated patients with TBI is rare and varies significantly across hospitals. Patients who received ECMO had longer hospital and ICU stays as well as longer durations of mechanical ventilation compared to those who did not receive ECMO. The hospital mortality rate was also higher in patients exposed to ECMO.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kaile Zhou, Yi-Ju Li, Erik J. Soderblom, Alexander Reed, Vaibhav Jain, Shuming Sun, M. Arthur Moseley, Virginia Byers Kraus
Summary: This study aimed to identify blood markers for predicting clinically relevant knee osteoarthritis (OA) progression over 48 months. A set of 15 serum proteomic markers corresponding to 13 proteins showed a high accuracy (73% AUC) in differentiating progressors from nonprogressors in a cohort of 596 knee OA patients. The predictive power of these blood markers was superior to traditional methods and the current best-in-class biomarker for OA progression. The findings were also confirmed in a second cohort of 86 individuals, further validating the generalizability of the marker set.
Correction
Anesthesiology
Jeffrey N. Browndyke, Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, Michael J. Devinney, Leslie Shaw, Teresa Waligorska, Eugene W. Moretti, Heather E. Whitson, Harvey J. Cohen, Joseph P. Mathew, Miles Berger
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Letter
Anesthesiology
Christopher D. Lascola, Sarah F. Cotter, Rebecca Y. Klinger, Tiffany Bisanar, Mary Cooter Wright, Miles Berger, Gavin Martin, Mihai V. Podgoreanu, Mark F. Newman, Niccolo Terrando, Joseph P. Mathew
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Jay B. Lusk, Anna Covington, Li Liu, Daniel P. Weikel, Yi-Ju Li, Padmini Sekar, Stacie L. Demel, Yasmin N. Aziz, Chelsea S. Kidwell, Daniel Woo, Michael L. James
Summary: The study evaluated the association between hyperglycemia, ischemic lesions, and functional outcomes after intracerebral hemorrhage (ICH). It found that a medical history of diabetes and the presence of DWI lesions were independently associated with poor functional outcomes after ICH, but no association was found between hyperglycemia and DWI lesions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kamrouz Ghadimi, Jhaymie L. Cappiello, Mary Cooter Wright, Jerrold H. Levy, Benjamin S. Bryner, Adam D. Devore, Jacob N. Schroder, Chetan B. Patel, Sudarshan Rajagopal, Svati H. Shah, Carmelo A. Milano
Summary: In patients undergoing major cardiac surgery for advanced heart failure, inhaled pulmonary-selective vasodilator treatment using iEPO was associated with similar risks for RVF development and development of other postoperative secondary outcomes compared with treatment using iNO.
Article
Cardiac & Cardiovascular Systems
Veraprapas Kittipibul, Arun Ganesh, Aubrie Coburn, Brian J. Coyne, James Matthew Gray, Jeroen Molinger, Neil Ray, Mihai Podgoreanu, Sharon L. McCartney, Negmeldeen Mamoun, Robert Curtis Fitzhugh, Philipp Lurz, Cynthia L. Green, Adrian F. Hernandez, Manesh R. Patel, Marat Fudim
Summary: Splanchnic nerve modulation is an emerging procedure to reduce cardiac filling pressures in heart failure. This study examines the changes in venous capacitance before and after SNM to evaluate its effectiveness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Meeting Abstract
Clinical Neurology
Heberto Suarez-Roca, Negmeldeen Mamoun, Lana L. Watkins, Andrey V. Bortsov, Joseph P. Mathew
Meeting Abstract
Clinical Neurology
Matthew Z. Yuan, Junli Zhao, Aidan McGinnis, Joseph P. Mathew, Fan Wang, Ru-Rong Ji