Article
Pharmacology & Pharmacy
Priyanka Basak, Priyanka Maitra, Uzma Khan, Kalyani Saha, Satya Sundar Bhattacharya, Moumita Dutta, Sushmita Bhattacharya
Summary: This study reveals that capsaicin inhibits the growth of Shigella flexneri by inducing autophagy and activating the transcription factor TFEB. The findings suggest that capsaicin-induced autophagy is one of the key factors responsible for bacterial clearance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Shiuan-Tze Wu, Jen-Yung Chen, Vanessa Martin, Renny Ng, Ye Zhang, Dhruv Grover, Ralph J. Greenspan, Johnatan Aljadeff, Chih-Ying Su
Summary: This study reveals the existence of an olfactory valence map in Drosophila sensory hairs, which is organized by ephaptic coupling and plays a crucial role in regulating behavior and processing odor mixtures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Instruments & Instrumentation
Shivani Saraf, Sanjay K. Jain
Summary: This project aims to increase the delivery of drugs to solid tumors by using endosomal escape. Topotecan and capsaicin were encapsulated in liposomes to improve therapeutic efficacy. The developed pH-sensitive liposomes showed improved intracellular drug delivery and demonstrated potential for targeted drug delivery to solid tumors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Anuja R. Bony, Jeffrey R. McArthur, Rocio K. Finol-Urdaneta, David J. Adams
Summary: This study is the first to report the potentiation of GIRK channels via allosteric alpha-conotoxin Vc1.1-GABA(B) receptor agonism, leading to decreased neuronal excitability. This finding contributes to the understanding of the analgesic effects of Vc1.1 and baclofen in vivo.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anuja R. Bony, Jeffrey R. McArthur, Rocio K. Finol-Urdaneta, David J. Adams
Summary: The study shows that analgesic alpha-conotoxins potentiate GIRK channels via GABA(B) receptor-dependent mechanisms, leading to decreased neuronal excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Luisa Zupin, Egidio Barbi, Raffaella Sagredini, Giulia Ottaviani, Sergio Crovella, Fulvio Celsi
Summary: This study found that PBMT at 800 and 970 nm wavelengths has a positive effect on nociceptive sensory neuronal cell line by reducing capsaicin-induced calcium flow, increasing ATP, and MMP hyperpolarization. Additionally, the 800 nm wavelength also increased ROS and O-2(-) levels.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Fisheries
Hengwei Deng, Yeyu Li, Jinling Li, Wenjie Shen, Qiankang Chen, Shaoping Weng, Jianguo He, Xiaopeng Xu
Summary: Neomycin can inhibit ISKNV infection by antagonizing the shift of cellular redox balance and down-regulating the expression of major capsid protein. The current study suggests that targeting the viral-induced redox imbalance can be used as a therapeutic strategy for Megalocytivirus diseases.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Daniel I. Brierley, Marie K. Holt, Arashdeep Singh, Alan de Araujo, Molly McDougle, Macarena Vergara, Majd H. Afaghani, Shin Jae Lee, Karen Scott, Calyn Maske, Wolfgang Langhans, Eric Krause, Annette de Kloet, Fiona M. Gribble, Frank Reimann, Linda Rinaman, Guillaume de Lartigue, Stefan Trapp
Summary: GLP-1 suppresses eating through independent gut-brain circuits, with PPG(NTS) neurons not being necessary for the eating suppression effects of GLP-1 receptor agonists. Concurrent activation of PPG(NTS) neurons can more effectively suppress eating than using semaglutide alone.
Article
Neurosciences
Leah J. Elias, Ishmail Abdus-Saboor
Summary: Social touch plays a crucial role in mental and physical well-being. The COVID-19 pandemic has highlighted the negative consequences of social isolation. Further research is needed to understand the neurobiology of social touch and explore potential therapeutic targets for related disorders.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Tana S. Pottorf, Travis M. Rotterman, William M. McCallum, Zoe A. Haley-Johnson, Francisco J. Alvarez
Summary: Peripheral nerve injuries trigger immune reactions in the spinal cord which are mainly governed by microglia activation. The mechanisms of microglial activation and response vary depending on the location, type, severity, and proximity of the injury, as well as the age and species of the organism. Recent advancements in neuro-immune research techniques have provided insights into the mechanisms of microglial activation and their function in injured motoneurons and sensory afferents. This review provides a comparative analysis of the dorsal and ventral horns regarding microglial activation mechanisms and their functionality in neuroprotection, degeneration, regeneration, synaptic plasticity, and spinal circuit reorganization following peripheral nerve injury, aiming to address unsettled controversies on the diversity of spinal microglial-neuronal interactions.
Article
Neurosciences
Hongsheng Wang, Wenbing Chen, Zhaoqi Dong, Guanglin Xing, Wanpeng Cui, Lingling Yao, Wen-Jun Zou, Heath L. Robinson, Yaoyao Bian, Zhipeng Liu, Kai Zhao, Bin Luo, Nannan Gao, Hongsheng Zhang, Xiao Ren, Zheng Yu, James Meixiong, Wen-Cheng Xiong, Lin Mei
Summary: A study has identified ErBB4 as a marker for heat-sensitive spinal neurons in mice, which receive inputs from nociceptors and form excitatory synapses onto target neurons. Activation of these neurons enhances heat response, while inhibition reduces it. NRG1 regulates this process by promoting glutamatergic transmission through the dynamic activity of the tyrosine kinase. This research reveals the spinal neuron connection and regulatory mechanism of heat sensation involving the NRG1-ErBB4 signaling.
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cell Biology
Shanshan Zhong, Fangxi Liu, Rashid Giniatullin, Jukka Jolkkonen, Yong Li, Zhike Zhou, Xinyu Lin, Chang Liu, Xiuchun Zhang, Zhouyang Liu, Cheng Lv, Qianqian Guo, Chuansheng Zhao
Summary: This study analyzed the microbiome and metabolome of feces and serum from breast cancer patients receiving paclitaxel treatment. The results showed that increased levels of deoxycholic acid (DCA) due to the growth of Clostridium species were associated with severe neuropathy. DCA further induced overexpression of CCR5 in dorsal root ganglion (DRG) through the TGR5 receptor, leading to neuronal hyperexcitability. Inhibition of CCR5 suppressed the development of neuropathic nociception.
Article
Neurosciences
Makiko Kashio, Makoto Tominaga
Summary: This article focuses on thermo-transient receptor potential ion channels (thermo-TRPs) expressed in somatosensory neurons and their role in temperature sensation.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Article
Anesthesiology
M. Danilo Boada, Thomas J. Martin, Renee Parker, Timothy T. Houle, James C. Eisenach, Douglas G. Ririe
Article
Anesthesiology
M. Danilo Boada, Douglas G. Ririe, Conner W. Martin, Salem J. Martin, Susy A. Kim, James C. Eisenach, Thomas J. Martin
Article
Anesthesiology
Deborah J. Culley, Max B. Kelz, Colleen G. Koch, James C. Eisenach, Mark D. Neuman, Elizabeth L. Whitlock, Rose Marie Robertson, Thomas Cooper, Paul Pomerantz
ANESTHESIA AND ANALGESIA
(2020)
Article
Anesthesiology
Brian M. Ilfeld, Bahareh Khatibi, Kamal Maheshwari, Sarah J. Madison, Wael Ali Sakr Esa, Edward R. Mariano, Michael L. Kent, Steven Hanling, Daniel Sessler, James C. Eisenach, Steven P. Cohen, Edward J. Mascha, Chao Ma, Jennifer A. Padwal, Alparslan Turan
Summary: The study found that a 6-day continuous peripheral nerve block can reduce phantom limb pain and improve physical and emotional dysfunction in patients for at least 1 month. Patients who received local anesthesia showed better improvement in overall impression of change and reduction in pain-induced physical and emotional dysfunction, but not in depression scores.
Review
Anesthesiology
Brian M. Ilfeld, James C. Eisenach, Rodney A. Gabriel
Summary: The study demonstrates that overexpressing a nonconducting TRPC6 channel can partially ameliorate the imbalance of calcium and sodium in muscle caused by RYR1 variants, prolonging survival time during halothane exposure, but is not sufficient to prevent the lethal effects of exposure to volatile anesthetic malignant hyperthermia-triggering agents.
Article
Anesthesiology
Brian M. Ilfeld, Harold Gelfand, Sandeep Dhanjal, Robert Hackworth, Anthony Plunkett, Alparslan Turan, Alice M. Vijjeswarapu, Steven P. Cohen, James C. Eisenach, Scott Griffith, Steven Hanling, Edward J. Mascha, Daniel Sessler
Article
Anesthesiology
Brian M. Ilfeld, Anthony Plunkett, Alice M. Vijjeswarapu, Robert Hackworth, Sandeep Dhanjal, Alparslan Turan, Steven P. Cohen, James C. Eisenach, Scott Griffith, Steven Hanling, Daniel Sessler, Edward J. Mascha, Dongsheng Yang, Joseph W. Boggs, Amorn Wongsarnpigoon, Harold Gelfand
Summary: Percutaneous peripheral nerve stimulation reduced pain scores and opioid requirements without systemic side effects during at least the initial week after ambulatory orthopedic surgery. This study helps pave the way for future clinical trials.
Review
Anesthesiology
Jennifer S. Gewandter, Shannon M. Smith, Robert H. Dworkin, Dennis C. Turk, Tong J. Gan, Ian Gilron, Sharon Hertz, Nathaniel P. Katz, John D. Markman, Srinivasa N. Raja, Michael C. Rowbotham, Brett R. Stacey, Eric C. Strain, Denham S. Ward, John T. Farrar, Kurt Kroenke, James P. Rathmell, Richard Rauck, Colville Brown, Penney Cowan, Robert R. Edwards, James C. Eisenach, McKenzie Ferguson, Roy Freeman, Roy Gray, Kathryn Giblin, Hanna Grol-Prokopczyk, Jennifer Haythornthwaite, Robert N. Jamison, Marc Martel, Ewan McNicol, Michael L. Oshinsky, Friedhelm Sandbrink, Joachim Scholz, Richard Scranton, Lee S. Simon, Deborah Steiner, Kenneth Verburg, Ajay D. Wasan, Kerry Wentworth
Summary: Randomized clinical trials have shown the efficacy of opioid analgesics in pain management, but they also come with significant risks. Efforts to reduce their use are ongoing, with IMMPACT providing recommendations for opioid-sparing clinical trial design. These recommendations aim to guide the design, conduct, analysis, and interpretation of future trials.
Article
Behavioral Sciences
Douglas G. Ririe, James C. Eisenach, Thomas J. Martin
Summary: Early life surgery can have long-term effects on anxiety, attentional dysfunction, and opioid reward behaviors in rats, with increased anxiety, impaired attention with audiovisual distraction, and greater opioid intake observed in animals subjected to surgery.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Anesthesiology
Brian M. Ilfeld, Bahareh Khatibi, Kamal Maheshwari, Sarah J. Madison, Wael Ali Sakr Esa, Edward R. Mariano, Michael L. Kent, Steven Hanling, Daniel Sessler, James C. Eisenach, Steven P. Cohen, Edward J. Mascha, Dongsheng Yang, Jennifer A. Padwal, Alparslan Turan
Summary: Continuous peripheral nerve block can alleviate phantom and residual limb pain during the infusion period, but few improvements were observed until 28 days after catheter removal.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medicine, Research & Experimental
Brian M. Ilfeld, Anthony Plunkett, Alice M. Vijjeswarapu, Robert Hackworth, Sandeep Dhanjal, Alparslan Turan, Steven P. Cohen, James C. Eisenach, Scott Griffith, Steven Hanling, Daniel I. Sessler, Edward J. Mascha, Yanyan Han, Joseph W. Boggs, Amorn Wongsarnpigoon, Harold Gelfand
Summary: The study shows that ambulatory percutaneous PNS for brachial plexus and sciatic nerve leads significantly reduces postoperative pain and opioid consumption. This treatment approach demonstrates effectiveness in acute pain management following orthopedic surgery, without systemic side effects.
Article
Anesthesiology
James C. Eisenach, Regina S. Curry, Timothy T. Houle
Summary: This study compared the effects of intrathecal oxytocin and placebo on neuropathic pain and mechanical hyperalgesia. The results showed that oxytocin reduced pain intensity more than placebo, but also increased the hyperalgesic area. Although limited by the small sample size, further research on spinal oxytocin in this population is warranted.
Article
Neurosciences
Vipin Arora, Carlos Eduardo Morado-Urbina, Young S. Gwak, Renee A. Parker, Carol A. Kittel, Enriqueta Munoz-Islas, Juan Miguel Jimenez-Andrade, E. Alfonso Romero-Sandoval, James C. Eisenach, Christopher M. Peters
Summary: Activation of Beta 2 adrenergic receptors has been shown to alleviate postoperative mechanical hypersensitivity, with more significant effects in depleted rats. Treatment with clenbuterol can reduce mechanical hypersensitivity, but has no significant impact on the speed of postoperative recovery. The study suggests that Beta 2 adrenergic receptors play a regulatory role in postoperative hypersensitivity in the nervous system.
Article
Anesthesiology
Stacie Deiner, Lee A. Fleisher, Jacqueline M. Leung, Carol Peden, Thomas Miller, Mark D. Neuman, Mark D. Neuman, Mark D. Neuman, Shamsuddin Akhtar, Sona Arora, Itay Bentov, Sujatha Bhandary, Marek Brzezinski, Ruth E. Burstrom, Stacie Deiner, Kevin Evans, Jacqueline Leung, Michael C. Lewis, Sohail Mahboobi, Julie McSwain, Alec Rooke, Robert Whittington, Wendy Woo, Zhongcong Xie, Lee A. Fleisher, Stacie G. Deiner, Roderic G. Eckenhoff, Carol J. Peden, Alexander A. Hannenberg, Daniel J. Cole, James C. Eisenach, Hugh C. Hemmings, Keith A. Jones, Evan D. Kharasch, Jeffrey R. Kirsch, Aman Mahajan, Jeanine P. Wiener-Kronish
PERIOPERATIVE MEDICINE
(2020)
Article
Neurosciences
Silvia Gutierrez, P. Abigail Alvarado-Vazquez, James C. Eisenach, E. Alfonso Romero-Sandoval, M. Danilo Boada