Antiplatelet Drugs

Dual antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: A position statement of the Canadian Cardiovascular Society

(2011) David Fitchett et al.   CANADIAN JOURNAL OF CARDIOLOGY

High-Dose Tranexamic Acid Is Associated with Nonischemic Clinical Seizures in Cardiac Surgical Patients

(2010) John M. Murkin et al.   ANESTHESIA AND ANALGESIA

Multidisciplinary Approach to the Challenge of Hemostasis

(2010) Jerrold H. Levy et al.   ANESTHESIA AND ANALGESIA

Cardiac Risk of Noncardiac Surgery after Percutaneous Coronary Intervention with Drug-eluting Stents

(2010) Jennifer A. Rabbitts et al.   ANESTHESIOLOGY

Time and Cardiac Risk of Surgery after Bare-metal Stent Percutaneous Coronary Intervention

(2010) Gregory A. Nuttall et al.   ANESTHESIOLOGY

Clopidogrel Increases Blood Transfusion and Hemorrhagic Complications in Patients Undergoing Cardiac Surgery

(2010) Christine R. Herman et al.   ANNALS OF THORACIC SURGERY

Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

Changes in Inflammatory Biomarkers in Patients Treated With Ticagrelor or Clopidogrel

(2010) Steen Husted et al.   CLINICAL CARDIOLOGY

Premature preoperative discontinuation of antiplatelet drug therapy in cardiovascular risk patients: a preliminary study on the role of P2Y12 receptor monitoring

(2010) Helfried Metzler et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y12 receptor antagonist, in healthy subjects

(2010) Renli Teng et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study

(2010) Robert F. Storey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Double-Blind, Randomized Study on Prevention and Existence of a Rebound Phenomenon of Platelets After Cessation of Clopidogrel Treatment

(2010) Dirk Sibbing et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study

(2010) Christopher P Cannon et al.   LANCET

Advances in Antiplatelet Therapy: Agents in Clinical Development

(2009) Dominick J. Angiolillo et al.   AMERICAN JOURNAL OF CARDIOLOGY

Relation of Body Mass Index to High On-Treatment Platelet Reactivity and of Failed Clopidogrel Dose Adjustment According to Platelet Reactivity Monitoring in Patients Undergoing Percutaneous Coronary Intervention

(2009) Nathalie Bonello-Palot et al.   AMERICAN JOURNAL OF CARDIOLOGY

Role of Antiplatelet Therapy Across the Spectrum of Patients with Coronary Artery Disease

(2009) Deepak L. Bhatt   AMERICAN JOURNAL OF CARDIOLOGY

Variability in Responsiveness to Oral Antiplatelet Therapy

(2009) Dominick J. Angiolillo   AMERICAN JOURNAL OF CARDIOLOGY

Role of Platelets in Atherothrombosis

(2009) Lisa K. Jennings   AMERICAN JOURNAL OF CARDIOLOGY

The Influence of Aprotinin and Tranexamic Acid on Platelet Function and Postoperative Blood Loss in Cardiac Surgery

(2009) Andinet M. Mengistu et al.   ANESTHESIA AND ANALGESIA

Coronary Artery Stents: II. Perioperative Considerations and Management

(2009) Lisa T. Newsome et al.   ANESTHESIA AND ANALGESIA

Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention

(2009) Lisa T. Newsome et al.   ANESTHESIA AND ANALGESIA

The Risk-Benefit Profile of Aprotinin Versus Tranexamic Acid in Cardiac Surgery

(2009) Keyvan Karkouti et al.   ANESTHESIA AND ANALGESIA

Transfusion and Pulmonary Morbidity After Cardiac Surgery

(2009) Colleen Koch et al.   ANNALS OF THORACIC SURGERY

The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass

(2009) Mike Reinhöfer et al.   BLOOD COAGULATION & FIBRINOLYSIS

Antifibrinolytics in cardiac surgical patients receiving aspirin: a systematic review and meta-analysis

(2009) D.R. McIlroy et al.   BRITISH JOURNAL OF ANAESTHESIA

A population-based study of the drug interaction between proton pump inhibitors and clopidogrel

(2009) D. N. Juurlink et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Safety and Efficacy of Recombinant Activated Factor VII

(2009) Ravi Gill et al.   CIRCULATION

Cardiovascular Outcomes and Mortality in Patients Using Clopidogrel With Proton Pump Inhibitors After Percutaneous Coronary Intervention or Acute Coronary Syndrome

(2009) Jeremy A. Rassen et al.   CIRCULATION

Bedside Evaluation of Thienopyridine Antiplatelet Therapy

(2009) Matthew J. Price   CIRCULATION

Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

(2009) Paul A. Gurbel et al.   CIRCULATION

Noncardiac Surgery and Bleeding After Percutaneous Coronary Intervention

(2009) Andrew C.Y. To et al.   Circulation-Cardiovascular Interventions

The genetics of antiplatelet drug resistance

(2009) G Feher et al.   CLINICAL GENETICS

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

(2009) Lena M. Napolitano et al.   CRITICAL CARE MEDICINE

New P2Y12 antagonists

(2009) Alan D Michelson   CURRENT OPINION IN HEMATOLOGY

Protocol Based on Thromboelastograph (TEG) Out-Performs Physician Preference Using Laboratory Coagulation Tests to Guide Blood Replacement During and After Cardiac Surgery: A Pilot Study

(2009) Andrew J. Westbrook et al.   Heart Lung and Circulation

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aspirin for the Prevention of Cardiovascular Events in Patients With Peripheral Artery Disease

(2009) Jeffrey S. Berger et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thromboelastography-Based Transfusion Algorithm Reduces Blood Product Use after Elective CABG: A Prospective Randomized Study

(2009) Koray Ak et al.   JOURNAL OF CARDIAC SURGERY

The Utility of Thromboelastography for Guiding Recombinant Activated Factor VII Therapy for Refractory Hemorrhage After Cardiac Surgery

(2009) Marcin Wąsowicz et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Randomized Comparison of Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With High Post-Treatment Platelet Reactivity

(2009) Young-Hoon Jeong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antiplatelet agents used for early intervention in acute coronary syndrome: Myocardial salvage versus bleeding complications

(2009) Sary F. Aranki et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to cyp 2c19*2 genotype: first experience in patients

(2009) P. A. GURBEL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial

(2009) Gilles Montalescot et al.   LANCET

Limitations of current therapies to prevent thrombosis: a need for novel strategies

(2009) Jean-Etienne Fabre et al.   Molecular BioSystems

Intravenous Platelet Blockade with Cangrelor during PCI

(2009) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

(2009) Robert A. Harrington et al.   NEW ENGLAND JOURNAL OF MEDICINE

The link between heightened thrombogenicity and inflammation: Pre-procedure characterization of the patient at high risk for recurrent events after stenting

(2009) Paul A. Gurbel et al.   PLATELETS

Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations inP2RY12, P2RY1,andITGB3

(2009) Robert F. Storey et al.   PLATELETS

Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response

(2009) Michael A. Flierl et al.   PLoS One

β2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury

(2009) James Rough et al.   SURGERY

Transfusion of red blood cells: the impact on short-term and long-term survival after coronary artery bypass grafting, a ten-year follow-up

(2009) Albert H.M. van Straten et al.   Interactive Cardiovascular and Thoracic Surgery

Effect of clopidogrel on perioperative blood loss and transfusion in coronary artery bypass graft surgery

(2009) Akmal Badreldin et al.   Interactive Cardiovascular and Thoracic Surgery

Antiplatelet drug nonresponsiveness

(2008) Patrick Gladding et al.   AMERICAN HEART JOURNAL

High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients—A Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 (PROVE IT–TIMI 22) analysis

(2008) Amir Lotfi et al.   AMERICAN HEART JOURNAL

Clopidogrel use and bleeding after coronary artery bypass graft surgery

(2008) John Hyung-Jun Kim et al.   AMERICAN HEART JOURNAL

Comparison of Higher Clopidogrel Loading and Maintenance Dose to Standard Dose on Platelet Function and Outcomes After Percutaneous Coronary Intervention Using Drug-Eluting Stents

(2008) Mohammed Abuzahra et al.   AMERICAN JOURNAL OF CARDIOLOGY

The Antiplatelet Effect of Six Non-Steroidal Anti-Inflammatory Drugs and Their Pharmacodynamic Interaction With Aspirin in Healthy Volunteers

(2008) Patrick A. Gladding et al.   AMERICAN JOURNAL OF CARDIOLOGY

Comparison of Increased Aspirin Dose Versus Combined Aspirin Plus Clopidogrel Therapy in Patients With Diabetes Mellitus and Coronary Heart Disease and Impaired Antiplatelet Response to Low-Dose Aspirin

(2008) Mehmet Akif Duzenli et al.   AMERICAN JOURNAL OF CARDIOLOGY

Comparison of the Impact of Short (

(2008) Subhash Banerjee et al.   AMERICAN JOURNAL OF CARDIOLOGY

An Evaluation of Cyclooxygenase-1 Inhibition Before Coronary Artery Surgery: Aggregometry Versus Patient Self-Reporting

(2008) Niels Rahe-Meyer et al.   ANESTHESIA AND ANALGESIA

Point-of-Care Whole Blood Impedance Aggregometry Versus Classical Light Transmission Aggregometry for Detecting Aspirin and Clopidogrel: The Results of a Pilot Study

(2008) Corinna Velik-Salchner et al.   ANESTHESIA AND ANALGESIA

Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices

(2008) Michael T. Ganter et al.   ANESTHESIA AND ANALGESIA

The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis

(2008) D. Henry et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Executive Summary

(2008) Jack Hirsh et al.   CHEST

Antithrombotic Therapy for Peripheral Artery Occlusive Disease

(2008) Michael Sobel et al.   CHEST

Antithrombotic Therapy for Non–ST-Segment Elevation Acute Coronary Syndromes

(2008) Robert A. Harrington et al.   CHEST

Antiplatelet Drugs

(2008) Carlo Patrono et al.   CHEST

Antithrombotic and Thrombolytic Therapy for Ischemic Stroke

(2008) Gregory W. Albers et al.   CHEST

The Primary and Secondary Prevention of Coronary Artery Disease

(2008) Richard C. Becker et al.   CHEST

Antithrombotic Therapy in Atrial Fibrillation

(2008) Daniel E. Singer et al.   CHEST

The Perioperative Management of Antithrombotic Therapy

(2008) James D. Douketis et al.   CHEST

Acute ST-Segment Elevation Myocardial Infarction

(2008) Shaun G. Goodman et al.   CHEST

Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38

(2008) Stephen D. Wiviott et al.   CIRCULATION

Incomplete Inhibition of Thromboxane Biosynthesis by Acetylsalicylic Acid

(2008) John W. Eikelboom et al.   CIRCULATION

ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

(2008) et al.   CIRCULATION

How to manage patients with need for antiplatelet therapy in the setting of (un-)planned surgery

(2008) Helge Möllmann et al.   Clinical Research in Cardiology

Antiplatelet profiles of the fixed-dose combination of extended-release dipyridamole and low-dose aspirin compared with clopidogrel with or without aspirin in patients with type 2 diabetes and a history of transient ischemic attack: A randomized, single-blind, 30-day trial

(2008) Victor L. Serebruany et al.   CLINICAL THERAPEUTICS

The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies

(2008) J. C.J. Sun et al.   EUROPEAN HEART JOURNAL

Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients

(2008) M. Lordkipanidze et al.   EUROPEAN HEART JOURNAL

Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial

(2008) S. A. Murphy et al.   EUROPEAN HEART JOURNAL

A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study

(2008) D. J. Angiolillo et al.   EUROPEAN HEART JOURNAL

Aspirin in coronary artery bypass surgery: new aspects of and alternatives for an old antithrombotic agent

(2008) Norbert Zimmermann et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Bleeding risks of combination vs. single antiplatelet therapy: a meta-analysis of 18 randomized trials comprising 129 314 patients

(2008) Victor L. Serebruany et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Incidence of Death and Acute Myocardial Infarction Associated With Stopping Clopidogrel After Acute Coronary Syndrome

(2008) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel

(2008) David S. Small et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Type 3 Phosphodiesterase Inhibitors May Be Protective Against Cerebrovascular Events in Patients with Claudication

(2008) William M. Stone et al.   Journal of Stroke & Cerebrovascular Diseases

Incidence and Clinical Impact of Dual Nonresponsiveness to Aspirin and Clopidogrel in Patients With Drug-Eluting Stents

(2008) Anna Maria Gori et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Early and Late Benefits of Prasugrel in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention

(2008) Elliott M. Antman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Clopidogrel in Patients With Acute Coronary Syndromes Requiring Coronary Artery Bypass Surgery

(2008) Jeffrey S. Berger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance

(2008) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

(2008) David Erlinge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects)

(2008) William R. Hiatt et al.   JOURNAL OF VASCULAR SURGERY

Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial

(2008) Stephen D Wiviott et al.   LANCET

Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study

(2008) Yining Huang et al.   LANCET NEUROLOGY

Cardiovascular Outcomes after a Change in Prescription Policy for Clopidogrel

(2008) Cynthia A. Jackevicius et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clopidogrel-Associated Bleeding and Related Complications in Patients Undergoing Coronary Artery Bypass Grafting

(2008) A. Simon Pickard et al.   PHARMACOTHERAPY

Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Subjects

(2008) Nagy A Farid et al.   PHARMACOTHERAPY

The use of the VerifyNowsystem to monitor antiplatelet therapy: A review of the current evidence

(2008) J. W. van Werkum et al.   PLATELETS

Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects

(2008) Christopher D. Payne et al.   PLATELETS

Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

(2008) Robert J. Adams et al.   STROKE

Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19⁎2 allele on clopidogrel responsiveness

(2007) Pierre Fontana et al.   THROMBOSIS RESEARCH

Rebound platelet activation after termination of prasugrel and aspirin therapy due to confirmed non-compliance in patient enrolled in the JUMBO Trial

(2006) V. L. SEREBRUANY et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE