Review
Surgery
Pedro Norton, Fernando A. M. Herbella, Francisco Schlottmann, Marco G. Patti
Summary: This study reviewed the evaluation of the upper esophageal sphincter (UES) using high-resolution manometry (HRM) and found that HRM allows for more precise measurements compared to conventional manometry, but the clinical significance of these parameters still needs confirmation. Various diseases can affect UES function, including achalasia, gastroesophageal reflux disease, globus, neurologic diseases, and Zenker's diverticulum.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Medicine, Research & Experimental
Frederik J. Meisoll, Michael Jungheim, Jacob F. Fast, Simone Miller, Martin Ptok
Summary: The study found that when triggering the laryngeal adductor reflex, two distinct pressure phases of the upper esophageal sphincter were identified, labeled as P1 and P2. P1 phase may be a result of vocal fold activity causing changes in UES pressure, while the constriction during P2 phase could strengthen the barrier function of the UES in preparation to clear the airways.
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Isis K. Araujo, Sabine Roman, Marie Napoleon, Francois Mion
Summary: The study found that using solid food swallows (SFS) during esophageal motility assessment can improve diagnostic accuracy and is important for diagnosing clinically relevant disorders. The application of solid food swallows in HRM has a significant impact on changing diagnoses and can be widely used in daily clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Hang Viet Dao, Long Bao Hoang, Hue Thi Minh Luu, Hoa Lan Nguyen, Robert Joel Goldberg, Jeroan Allison, An Thi Minh Dao, Hong Thi Van Nguyen, Tomoaki Matsumura, Long Van Dao
Summary: This study investigated the clinical symptoms, endoscopic findings, and LES characteristics of adult patients with absent contractility, as well as factors associated with erosive esophagitis. The results showed that male sex and low IRP4s were significantly associated with erosive esophagitis.
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Wei-Yi Lei
Summary: The study investigated the effects of acute administration of codeine on primary and secondary peristalsis in healthy adults. Results showed that codeine increased the relaxation pressure and frequency of secondary peristalsis, while also affecting primary peristalsis by increasing relaxation pressure and shortening distal latency. This suggests that opioids like codeine can impact both primary and secondary peristalsis in the esophagus.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Mentore Ribolsi, Matteo Ghisa, Edoardo Savarino
Summary: The article discusses investigations conducted using conventional manometry and high-resolution manometry (HRM) to explore the field of esophageal motility and understand the potential link between motor features and gastroesophageal reflux disease (GERD) pathogenesis. HRM studies have provided insights into the esophageal motor function in patients with various esophageal disorders, as well as the correlation between reduced esophageal motility, disruption of the esophagogastric junction, and gastroesophageal reflux burden.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Roberto Penagini, Nicola de Bortoli, Edoardo Savarino, Elena Arsie, Salvatore Tolone, Garrett Greenan, Pierfrancesco Visaggi, Daria Maniero, Aurelio Mauro, Dario Consonni, C. Prakash Gyawali
Summary: RDC during high-resolution manometry is an effective surrogate for TBE in assessing esophageal emptying in treated patients with achalasia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Otorhinolaryngology
Sophia M. Colevas, Lily N. Stalter, Corinne A. Jones, Timothy M. Mcculloch
Summary: This study describes the manometric representation of the resting upper esophageal sphincter (UES) using a clinically accessible method of measurement. The results demonstrate excellent within-subject reliability of the resting UES mean pressures and significant effects of age, number of sensors contained within the resting UES, and preceding swallow volume on mean resting UES pressure.
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Medicine, Research & Experimental
Dustin Romain, Lauran K. Evans, Yvette Diaz, Kathryn Allen, Kristine Galek
Summary: This study presented a rare case of hypotonic upper esophageal sphincter (UES), with the patient able to achieve a more normal swallow pressure pattern using biofeedback and a specific maneuver during manometry. It also highlighted the importance of combining manometry with other swallow imaging techniques for effective treatment planning and patient outcomes.
Article
Gastroenterology & Hepatology
Asad Jehangir, Zubair Malik, Henry P. Parkman
Summary: This study aimed to examine the correlation between reflux observed on esophagogastric junction (EGJ) during high-resolution esophageal manometry with impedance (HREMI) and reflux on conventional esophageal reflux monitoring studies. The results showed that about 20.5% of patients undergoing HREMI had pathologic reflux at EGJ. Patients with reflux on HREMI more frequently had gastroesophageal reflux disease (GERD) on ambulatory pH monitoring. However, reflux on HREMI had low sensitivity for GERD.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Aron Onerup, Eva Angenete, David Bock, Mats Borjesson, Monika Fagevik Olsen, Elin Gryback Gillheimer, Stefan Skullman, Sven-Egron Thorn, Eva Haglind, Hanna Nilsson
Article
Anesthesiology
R. Ahlstrand, J. Savilampi, S. -E. Thorn, M. Wattwil
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2011)
Article
Anesthesiology
Rebecca Ahlstrand, Sven-Egron Thorn, Anette Dahlkvist, Magnus Wattwil, Anders Magnuson
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2012)
Article
Anesthesiology
Jane Hayden, Anil Gupta, Sven-Egron Thorn, Pontus Thulin, Linda Block, Jonatan Oras
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2019)
Article
Surgery
Per Bjorklund, Almantas Maleckas, Hans Lonroth, Niclas Bjornfot, Sven Egron Thorn, Lars Fandriks
Article
Anesthesiology
Jane M. Hayden, Jonatan Oras, Linda Block, Sven-Egron Thorn, Charlotte Palmqvist, Sahar Salehi, Johan L. Nordstrom, Anil Gupta
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Article
Cell Biology
Aron Onerup, Sven-Egron Thorn, Eva Angenete, David Bock, Elin Gryback Gillheimer, Eva Haglind, Hanna Nilsson
GROWTH HORMONE & IGF RESEARCH
(2020)
Correction
Medicine, Research & Experimental
Aron Onerup, Eva Angenete, David Bock, Mats Borjesson, Monika Fagevik Olsen, Elin Gryback Gillheimer, Stefan Skullman, Sven-Egron Thorn, Eva Haglind, Hanna Nilsson
Article
Multidisciplinary Sciences
Malin Andersson, Jonatan Oras, Sven Egron Thorn, Ove Karlsson, Peter Kalebo, Henrik Zetterberg, Kaj Blennow, Lina Bergman
Summary: This case-control study found that women with preeclampsia have increased levels of NfL in both their CSF and plasma, with a strong correlation between the two. Additionally, levels of NSE and tau were reduced in the CSF of women with preeclampsia, but no significant differences were observed in plasma levels. Serum levels of S100B were elevated in preeclampsia, while CSF levels remained consistent with those of normal pregnancy.
Article
Surgery
Carl Johan Svensson, Christina E. Lundberg, Tatiana Zverkova Sandstrom, Paulin Andrell, Sven-Egron Thorn, Annika Rosengren, Axel Wolf
Summary: The study compared opioid consumption in patients with obesity who underwent RYGB surgery with population controls, and identified characteristics associated with opioid use.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Review
Anesthesiology
Alexander Olausson, Carl Johan Svensson, Paulin Andrell, Pether Jildenstal, Sven-Egron Thorn, Axel Wolf
Summary: This meta-analysis of 26 RCTs involving 1934 patients found that opioid-free anaesthesia significantly reduced adverse postoperative events, especially nausea and vomiting, and decreased postoperative opioid consumption. However, there was no significant difference in length of post-anaesthesia care unit stay and overall postoperative pain between the opioid-free and opioid-based general anaesthesia groups.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Lilja Thorgeirsdottir, Malin Andersson, Ove Karlsson, Sven-Egron Thorn, Jonatan Oras, Verena Sengpiel, Teresia Svanvik, Helen Elden, Karolina Linden, Katja Junus, Susanne Lager, Ida Enskar, Teelkien van Veen, Johan Wikstrom, Isabella Bjorkman-Burtscher, Anna Stigsdotter Neely, Anna-Karin Wikstrom, Lina Bergman
Summary: This study aims to establish a multicenter database and biobank for pre-eclampsia to contribute to safer and more individualized treatment and care. The focus is on studying the experiences of women with pre-eclampsia and their partners, as well as describing the phenotype of different subtypes of the disorder.
Article
Physiology
Niclas Carlberg, Catherine Cluver, Camilla Hesse, Sven-Egron Thorn, Robin Gandley, Tor Damen, Lina Bergman
Summary: This study compared circulating concentrations of glycocalyx degradation products in different degrees of preeclampsia severity. The results showed that thrombomodulin was associated with disease severity and may be valuable for risk-stratifying women with preeclampsia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Birgitta Platon, Sven-Egron Thorn, Clas Mannheimer, Paulin Andrell
OBSTETRICS & GYNECOLOGY SCIENCE
(2020)
Article
Anesthesiology
J. M. Hayden, J. Oras, O. I. Karlsson, K. G. Olausson, S. -E. Thorn, A. Gupta
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2017)