Article
Pediatrics
Paula Dias Maia, Jason Gien, John P. Kinsella, Jenny Zablah, Gareth Morgan, Dunbar Ivy, Steven H. Abman, Benjamin S. Frank
Summary: We analyzed the outcomes of cardiac catheterization in infants diagnosed with congenital diaphragmatic hernia (CDH) between 2009 and 2020. The results showed that all cases (n = 17) had pulmonary arterial hypertension confirmed by catheterization, and 53% of cases had left ventricular diastolic dysfunction (LVDD). LVDD was found to be associated with increased respiratory morbidity. Noninvasive assessments before the procedure did not consistently agree with the catheterization results.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Alberto Toso, Oscar Aranguiz, Carlos Cespedes, Orieta Navarrete, Cherie Hernandez, Carlos P. Vio, Matias Luco, Paola Casanello, Javier Kattan
Summary: This study evaluated the effects of antenatal sildenafil and ABH on lung development in a CDH rat model. The results showed that the combined treatment improved lung volume, pulmonary vascular development, and NO synthesis, while preventing smooth muscle cell hyperproliferation. This study highlights the importance of Arginase inhibition as a therapeutic target and the role of prenatal treatment in improving lung development in CDH.
PEDIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Gabriel Dumitrescu, Anna Januszkiewicz, Anna Agren, Maria Magnusson, Ernesto Sparrelid, Olav Rooyackers, Jan Wernerman
Summary: Plasma fibrinogen and albumin concentrations undergo changes after abdominal surgery. Fibrinogen concentration returns to or even exceeds the preoperative level on postoperative days 3-5, while albumin remains low. The underlying mechanisms behind these changes in plasma concentrations are still unclear.
Article
Respiratory System
Alain Boussuges, Julie Finance, Guillaume Chaumet, Fabienne Bregeon
Summary: Chest ultrasonography has been proven useful in diagnosing diaphragm dysfunction. This study aimed to establish normal values of diaphragmatic motion using M-mode ultrasonography in seated healthy volunteers, finding that men have larger diaphragmatic excursions. These normal values can be used by clinicians to detect diaphragmatic dysfunction, with different normal values for men and women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jui Fang, Yu-Cheng Shen, Yen-Nien Ting, Hsin-Yuan Fang, Yi-Wen Chen
Summary: ShanEnLM and DEAM can be used to quantitatively diagnose pneumothorax, with high accuracy in differentiating between various degrees of pneumothorax.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Pediatrics
Shazia Bhombal, Neil Patel
Summary: Congenital diaphragmatic hernia (CDH) is a common cause of neonatal morbidity and mortality. Pulmonary hypertension (PH) plays a crucial role in its pathophysiology, and the interplay between lung and heart dysfunction contributes to variable hemodynamic phenotypes in CDH. Clinical assessment of individual phenotype can guide personalized management strategies and improve outcomes. Ongoing research on the mechanisms of PH in CDH can provide support in treatment.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2022)
Review
Anesthesiology
Gabriel Prada, Antoine Vieillard-Baron, Archer K. Martin, Antonio Hernandez, Farouk Mookadam, Harish Ramakrishna, Jose L. Diaz-Gomez
Summary: Proficiency in cardiopulmonary ultrasound is essential for anesthesiologists and critical care physicians, with M-mode ultrasonographic imaging providing high temporal resolution. This review explores the contemporary applications of M-mode ultrasonography in critical care and perioperative medicine, focusing on tracheal, lung, and diaphragmatic ultrasound for diagnosis, monitoring, and guidance during procedures. The article highlights the importance of M-mode ultrasound in detecting specific conditions and its underuse in current clinical practice.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Otorhinolaryngology
Susanne Menzel, Antje Haehner, Dorothea Woosch, Belinda Marquardt, Cristina Ressel, Julia Draf, Giancarlo Ottaviano, Paolo Boscolo-Rizzo, Romina Kardashi, Katja de With, Yvonne Hackl, Thomas Hummel
Summary: This study aimed to evaluate the course of olfactory dysfunction due to upper respiratory tract infections, especially for COVID-19, and investigate possible predictors for the outcome. The results showed that COVID-19 patients had better overall olfactory function compared to non-COVID-19 patients, and both groups exhibited similar improvement over 3-4 months, except for a more pronounced improvement of odor threshold in COVID-19 patients. Younger patients with parosmia and lower olfactory scores at the first visit had a better prognosis in terms of olfactory recovery. No other significant predictors were found.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Acoustics
Yanyan Huang, Huohu Zhong, Zhirong Xu, Qichen Su, Shanshan Su
Summary: This study aimed to investigate the correlation between ultrasonic measurements of swallowing movement parameters and aggravation of swallowing dysfunction in patients with chronic obstructive pulmonary disease (COPD). The results showed that certain swallowing movement parameters were negatively associated with COPD-related swallowing issues while others were positively correlated. The severe group exhibited lower values for some parameters compared to the mild group. Receiver operating characteristic (ROC) curves demonstrated the promising diagnostic utility of these parameters for assessing the presence and severity of swallowing dysfunction in COPD patients.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Critical Care Medicine
Prasanna V. Vanamail, Kalpana Balakrishnan, Sarojini Prahlad, Punitha Chockalingam, Radhika Dash, Dinesh K. Soundararajan
Summary: Following upper abdominal surgery, diaphragmatic inspiratory amplitude (DIA) decreases and is significantly associated with postoperative pulmonary complications (PPCs). A DIA of less than 1.3 cm during quiet breathing and 1.6 cm during deep breathing in the left hemidiaphragm has a sensitivity of 77% and 75%, respectively, in diagnosing PPCs following upper abdominal surgery.
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Noha Gamal Ghoniem, Eman Shokry Abd-Allah, Ahmed Mohammed Said, Fatma Mohammed Ahmed Abd El-Fattah
Summary: Postoperative pulmonary complications (PPCs) are a serious outcome of upper abdominal surgery, leading to increased morbidity and mortality. This study aimed to investigate the impact of lung expansion modalities (LEMs) on the pulmonary function and incidence of PPCs in older adults. The study included 80 older adults (40 cases and 40 controls) and found that the study group had significantly improved forced expiratory volume, oxygen saturation, and reduced PPCs compared to the control group.
Article
Medicine, General & Internal
Jessica Schleifer, Hamid Shokoohi, Lauren Ann J. Selame, Andrew Liteplo, Sigmund Kharasch
Summary: The assessment of diaphragmatic function is crucial in emergency medicine and pediatrics. Angle-independent M-mode can provide a more accurate and consistent evaluation of diaphragmatic excursion. Utilizing a landmark-based approach can help maintain consistency in diaphragmatic analysis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert Damm, Romy Damm, Constanze Heinze, Alexey Surov, Jazan Omari, Maciej Pech, Maciej Powerski
Summary: The study evaluated the use of ultrasound during catheter placement in interstitial brachytherapy of abdominal malignancies, finding that ultrasound-assisted catheter placement can improve lesion visibility and reduce effective dose for patients, especially for larger lesions and those located in lower positions within the target organs.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2022)
Article
Surgery
Biruk Adie Admass, Birhanu Yilma Ego, Hailu Yimer Tawye, Seid Adem Ahmed
Summary: Thoraco-abdominal surgery can lead to lower lung volumes and a higher risk of post-operative pulmonary complications. This study aimed to determine the incidence and factors associated with these complications in patients undergoing such surgery in the Amhara region of Ethiopia. The study found that emergency procedures, preoperative hypoxemia, longer surgery durations, nasogastric tube placement, intraoperative blood loss, and post-operative hypoalbuminemia were associated with post-operative pulmonary complications.
FRONTIERS IN SURGERY
(2023)
Article
Anesthesiology
Amr Abdalla Elsayed, Eman Hashem Mohamed Neanaa, Bassem Nashaat Beshey
Summary: This prospective observational study aimed to investigate the predictive value of ultrasound-assessed diaphragmatic impairment (DI) on the need for invasive mechanical ventilation (IMV) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients treated with non-invasive ventilation (NIV), as well as the impact of DI on patient outcomes. The results showed that a diaphragmatic thickness fraction (DTF) cut-off value of less than 26-29% accurately predicted the probability of NIV failure and subsequent need for IMV. Patients with DI requiring IMV had significantly longer mechanical ventilation days, ICU stay, and higher 28-day mortality.
EGYPTIAN JOURNAL OF ANAESTHESIA
(2022)
Article
Orthopedics
Seokyung Shin, Yong Seon Choi, Hyejung Shin, Ick Hwan Yang, Kwan Kyu Park, Hyuck Min Kwon, Byunghag Kang, So Yeon Kim
Summary: The study found that preoperative carbohydrate drink did not reduce postoperative nausea and vomiting in diabetic patients undergoing total knee arthroplasty, but the Oral CHO group had a slight advantage in postoperative QoR scores. Preoperative CHO drink did not increase hyperglycemia, suggesting it may be a safe component of perioperative care in diabetic patients.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Environmental Sciences
Seungho Jung, Jeongmin Kim, Jiho Lee, Chooljae Rhee, Sungwon Na, Jin-Ha Yoon
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Clinical Neurology
Jeongmin Kim, Dain Choi, Myung Sun Yeo, Ga Eul Yoo, Soo Ji Kim, Sungwon Na
NATURE AND SCIENCE OF SLEEP
(2020)
Article
Multidisciplinary Sciences
Seung Hyun Kim, Hyang Mi Ju, Chong-Hyuck Choi, Hae Ri Park, Seokyung Shin
Summary: The study found that Propofol-based TIVA did not improve global QoR-40 scores compared to Desflurane-based inhalational anesthesia. However, it showed higher QoR-40 scores in the domain of physical independence and less postoperative nausea, suggesting that Propofol TIVA could be a useful option for patients undergoing corrective lower limb osteotomy.
Article
Cell Biology
Junyi Yan, Chun-Ling Sun, Seokyung Shin, Marc Van Gilst, C. Michael Crowder
Summary: The mitochondria are the main oxygen consumers in cells and are primarily affected by hypoxia. Research in C. elegans has shown that resistance to hypoxic cell death mitigates hypoxia-induced mitochondrial protein aggregation (HIMPA) and that activation of the mitochondrial unfolded protein response (UPRmt) also mitigates HIMPA. However, UPRmt activation is not necessary or sufficient for resistance to hypoxic cell death, indicating that UPRmt may protect against mitochondrial protein aggregation but not necessarily cell death in hypoxic conditions.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Seungho Jung, Jeongmin Kim, Sungwon Na, Won Seok Nam, Do-Hyeong Kim
Summary: In patients under low tidal volume mechanical ventilation, carotid corrected flow time (FTc) can predict fluid responsiveness better than pulse pressure variation (PPV). However, further studies are needed before its clinical use.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Hye-Bin Kim, Sungwon Na, Hyo Chae Paik, Hyeji Joo, Jeongmin Kim
Summary: The SOFA score and pH were found to be associated with an increased risk of ICU readmission, with infection-related causes being the most common reasons for ICU readmission and in-hospital mortality.
ACUTE AND CRITICAL CARE
(2021)
Article
Oncology
Seokyung Shin, Ki Jun Kim, Hye Jeong Hwang, Sewon Noh, Ju Eun Oh, Young-Chul Yoo
Summary: Dexmedetomidine does not affect cell viability or cell cycle, but can promote the recovery of NK cell activity, reduce cortisol and TNF-alpha levels, leading to a decrease in tumor burden after surgery. Further studies are needed to understand the mechanisms by which dexmedetomidine acts on cancer and immune cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yuki Kotani, Sungwon Na, Jason Phua, Nobuaki Shime, Tatsuya Kawasaki, Hideto Yasuda, Jong Hun Jun, Atsushi Kawaguchi
Summary: Although inadequate research support may contribute to poor research productivity among intensivists, the current research environment in critical care medicine in Asia has not been investigated. This study aimed to describe the research environment in Asian academia focusing on critical care. The results showed that dedicated time for research, working in a university-affiliated hospital, and having longer clinical experience were significantly associated with higher research productivity in three East Asian countries.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jiwoo Suh, Sungwon Na, Seungho Jung, Kwan Hyung Kim, Sungji Choo, JiYeon Choi, Jeongmin Kim
Summary: Restricting family visits in the ICU during the COVID-19 pandemic has raised concerns about the negative psychosocial consequences for patients and families. A study was conducted to compare the quality of life, depressive symptoms, and emotions of family caregivers before and during the pandemic, and to explore their perceptions and suggestions regarding visitation restrictions. The results showed that despite experiencing sadness and anxiety, visitation restrictions were necessary during the pandemic. Alternative visitation strategies are needed to mitigate psychological distress and provide sufficient information to ICU family caregivers.
Article
Psychology, Multidisciplinary
Ga Eul Yoo, Sungwon Na, Soo Ji Kim, Jeongmin Kim
Summary: This study surveyed family caregivers of patients in intensive care units during the COVID-19 pandemic to examine the impact of musical listening on their psychological well-being. The results showed that family caregivers reported significantly greater negative emotions during COVID-19, and personal music listening had a positive effect on perceived emotions. For quality of life, there was a significant effect of music listening, indicating a higher quality of life in the group who engaged in music listening.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Immunology
Su Hwan Lee, Ju Hye Shin, Min Woo Park, Junhyung Kim, Kyung Soo Chung, Sungwon Na, Ji-Hwan Ryu, Jin Hwa Lee, Moo Suk Park, Young Sam Kim, Jong-Seok Moon
Summary: The impairment of mitochondrial ATP synthesis may induce RIPK3-dependent necroptosis in lung epithelial cells during lung injury by lung inflammation, exacerbating lung tissue damage.
Article
Anesthesiology
Seon Ju Kim, Yong Seon Choi, Yong Min Chun, Hye Jin Kim, Chunggu Han, Seokyung Shin
Summary: Intravenous lidocaine may be helpful in reducing opioid requirements during the acute postoperative period in patients undergoing arthroscopic rotator cuff repair. It may be a viable option for multimodal analgesia in ARCR when regional analgesia is not possible.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Psychology, Educational
Ga Eul Yoo, Jeongmin Kim, Da In Choi, Myung Sun Yeo, Soo Ji Kim, Sungwon Na
Summary: This study investigated the psychological health of family caregivers of critically ill patients and found that engaging in music activities in daily life could alleviate emotional distress. Further research on diversified music use in critical care should include family caregivers.
PSYCHOLOGY OF MUSIC
(2021)
Article
Critical Care Medicine
Seungho Jung, Sungwon Na, Hye Bin Kim, Hye Ji Joo, Jeongmin Kim
ACUTE AND CRITICAL CARE
(2020)