Article
Clinical Neurology
Lara Jehi, Kees Braun
Summary: Various factors, including etiology and histopathology, play crucial roles in determining the outcomes of epilepsy surgery. This review aims to investigate the relationship between etiology and surgical outcomes, while exploring possible explanatory mechanisms.
Article
Surgery
Ellen A. Hancock, Kevin J. Hancock, Nandhika Wijay, Danielle Andry
Summary: This study found that female plastic surgery patients have a gender preference when choosing their surgeon. The majority of female patients prefer a female surgeon for breast procedures, while they lean towards a male surgeon for injectable and facial procedures. However, there is no gender preference for body procedures.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Surgery
Stacie Deiner, Xiaoyu Liu, Hung-Mo Lin, Rachelle Jacoby, Jong Kim, Mark G. Baxter, Frederick Sieber, Kenneth Boockvar, Mary Sano
Summary: Patients with POCD are more likely to experience new disability in activities of daily living after surgery, influenced by factors such as preoperative cognition and function, postoperative depression, and postoperative complications. Therefore, a comprehensive assessment of cognitive and functional status before surgery should be conducted to reduce the risk of new disability after surgery.
Article
Pharmacology & Pharmacy
Thien-Nga Chamaraux-Tran, Marie Muller, Julien Pottecher, Pierre A. Diemunsch, Catherine Tomasetto, Izzie-Jacques Namer, Nassim Dali-Youcef
Summary: Metabolomics and onco-anesthesia are emerging research fields in oncology. This study assessed the impact of lidocaine (LIDO) on the metabolomic fingerprint of breast cancer cells. Results showed that LIDO modulates cell metabolites levels and downregulates several pathways, suggesting its potential antitumor properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Philip S. Bauer, William C. Chapman, Chady Atallah, Bilal A. Makhdoom, Aneel Damle, Radhika K. Smith, Paul E. Wise, Sean C. Glasgow, Matthew L. Silviera, Steven R. Hunt, Matthew G. Mutch
Summary: In patients with nonmetastatic rectal cancer undergoing neoadjuvant short-course radiation therapy (SC-TNT) or conventional chemoradiotherapy (CRT) followed by proctectomy, there was no significant difference in perioperative complications between the two treatment regimens. SC-TNT did not significantly increase the risk of perioperative complications compared to CRT.
Article
Multidisciplinary Sciences
Kristian Brat, Zdenek Chovanec, Ladislav Mitas, Vladimir Sramek, Lyle J. Olson, Ivan Cundrle Jr
Summary: Post-operative oxygen therapy is commonly used, but its benefits on surgical site infection have been questioned. Hyperoxemia after thoracic surgery is not associated with post-operative complications or 30-day mortality.
Review
Hematology
Tammy Lam, Robert L. Medcalf, Geoffrey C. Cloud, Paul S. Myles, Charithani B. Keragala
Summary: Tranexamic acid is a widely used antifibrinolytic agent that reduces blood loss by impairing plasminogen and tissue-type plasminogen activator (tPA) interaction with lysine residues on the fibrin surface. However, plasmin has other binding sites that can affect immunity and inflammation. Despite extensive research on the optimal dosage to reduce bleeding rates, it remains unknown if these dosages also block the non-canonical effects of plasmin.
THROMBOSIS JOURNAL
(2023)
Article
Oncology
Ying Tong, Feixiang Sun, Chuanpeng Zhang, Susu Yang, Ziyi Yu, Yi Zhao
Summary: This study found that using the aggregate dimensions of all foci can better predict tumor behavior in multifocal and multicentric breast cancers. There is also histological and biological heterogeneity among different lesions, highlighting the necessity for examination of each lesion.
Article
Geriatrics & Gerontology
Jeremy Barben, Ariane Mamguem Kamga, Tienhan Sandrine Dabakuyo-Yonli, Arthur Hacquin, Alain Putot, Patrick Manckoundia, Leila Bengrine-Lefevre, Valerie Quipourt
Summary: Cervical cancer is more commonly diagnosed in older women and is associated with more advanced tumors and comorbidities in this population. Older women have lower treatment rates, a smaller proportion undergo surgery but a larger proportion receive radiotherapy. Age is a prognostic factor for cervical cancer.
Review
Oncology
Upendra K. Soni, Liam Jenny, Rashmi S. Hegde
Summary: The insulin-like growth factor receptor (IGF-1R) has been extensively studied as a potential target in oncology, but the initial promise has not been fulfilled due to resistance mechanisms and toxicities. Lack of patient stratification based on biomarkers in previous clinical trials has been recognized as a limitation. There is now growing interest in revisiting IGF-1R targeted therapeutics with predictive biomarker-driven patient stratification. The sub-cellular localization of IGF-1R has emerged as a potential biomarker.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Lukas Owens, Kemal Caglar Gogebakan, Usha Menon, Roman Gulati, Noel S. Weiss, Ruth Etzioni
Summary: Multicancer early detection tests are prompting a reconsideration of short-term endpoints for cancer screening trials. Stage-shift models that preserve prognostic subtype might predict different mortality reductions compared to models that ignore subtype. We examine the implications of preserving prognostic subtypes in ovarian and prostate cancers and its impact on short-term endpoints based on stage in cancer screening trials.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Anesthesiology
Chao Tong Teo, Jiawei Sean Wu, Karen Chan, Su Wei Bryan Ng, Jyoti Somani, Will Loh
Summary: Monkeypox is an emerging infectious disease that is spreading globally outside of West Africa and the Democratic Republic of Congo. The recent outbreak in 2022 has led to atypical presentations and increased risk for healthcare professionals. This paper aims to provide information on managing suspected or confirmed cases of monkeypox.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Review
Oncology
Dario Bugada, Megan Drotar, Simone Finazzi, Giovanni Real, Luca F. Lorini, Patrice Forget
Summary: This systematic review aimed to evaluate the effectiveness of opioid-free anesthesia (OFA) compared to opioid-based anesthesia (OBA) in cancer patients undergoing surgery. Only two eligible studies were found, with significant heterogeneity in outcomes. The results could not confirm or reject the ability of OFA to improve early postoperative outcomes in cancer surgery. More studies are needed with consistent methodology and endpoints.
Article
Surgery
Claudia Siniakowicz, Joshua B. Cadwell, Rose S. Maisner, Parisorn Thepmankorn, Lauren Zingaro, Vaishali Ravikumar, Haripriya S. Ayyala
Summary: The study found that academic productivity of integrated plastic surgery residents is associated with program reputation and affiliated medical school research rankings, which may be considered by applicants interested in research careers.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Kristen E. Rhodin, Sin-Ho Jung, Kelly Elleson, Danielle DePalo, Richard Straker, Sophia McKinley, Kate Beekman, Lily Parker, Suephy Chen, Matthew K. Iyer, April K. S. Salama, Edmund Bartlett, Giorgos Karakousis, Jonathan S. Zager, Douglas S. Tyler, Georgia M. Beasley
Summary: This study investigated the impact of the timing of adjuvant immune checkpoint inhibitor (ICI) initiation on survival in patients with stage III melanoma. The results showed that patients who initiated adjuvant ICI within 6 weeks of surgery had worse recurrence-free survival, while those who started treatment after 6 weeks had improved outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
