Article
Medicine, General & Internal
Christopher C. Giza, Michael McCrea, Daniel Huber, Kenneth L. Cameron, Megan N. Houston, Jonathan C. Jackson, Gerald McGinty, Paul Pasquina, Steven P. Broglio, Alison Brooks, John DiFiori, Stefan Duma, Jaroslaw Harezlak, Joshua Goldman, Kevin Guskiewicz, Thomas W. McAllister, David McArthur, Timothy B. Meier, Jason P. Mihalik, Lindsay D. Nelson, Steven Rowson, Jessica Gill
Summary: The study investigated acute blood protein levels in military cadets after combative training-associated concussions. Results suggest that blood biomarkers have potential for use as research tools to better understand the pathobiological changes associated with concussion and to assist with injury identification and recovery from combative training-associated concussions among military service academy cadets.
Article
Gastroenterology & Hepatology
Naroa Goikoetxea-Usandizaga, Miren Bravo, Leire Egia-Mendikute, Leticia Abecia, Marina Serrano-Macia, Rocio G. Urdinguio, Marc Clos-Garcia, Ruben Rodriguez-Agudo, Raquel Araujo-Legido, Lucia Lopez-Bermudo, Teresa C. Delgado, Sofia Lachiondo-Ortega, Irene Gonzalez-Recio, Claudia Gil-Pitarch, Ainize Pena-Cearra, Jorge Simon, Raquel Benede-Ubieto, Silvia Arino, Jose M. Herranz, Mikel Azkargorta, Julio Salazar-Bermeo, Nuria Marti, Marta Varela-Rey, Juan M. Falcon-Perez, Oscar Lorenzo, Ruben Nogueiras, Felix Elortza, Yulia A. Nevzorova, Francisco J. Cubero, Domingo Saura, Luis Alfonso Martinez-Cruz, Guadalupe Sabio, Asis Palazon, Pau Sancho-Bru, Natalia Elguezabal, Mario F. Fraga, Matias A. Avila, Ramon Bataller, Jose J. G. Marin, Franz Martin, Maria Luz Martinez-Chantar
Summary: Alcohol-associated liver disease (ALD), accounting for 70% of liver-related deaths in Europe, has no effective approved therapies. However, targeting methylation-controlled J protein (MCJ) may help in recovering mitochondrial fitness without collateral oxidative damage. Liver-specific MCJ silencing can prevent major ALD hallmarks, such as mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, improving lipid metabolism and liver injury.
Article
Biochemistry & Molecular Biology
Lei Peng, Yijing He, Weihan Wang, Yajie Chu, Qixin Lin, Rong Rui, Qiao Li, Shiqiang Ju
Summary: In this study, the importance of PAK1 in regulating spindle assembly and cell cycle progression during the first meiotic division of porcine oocytes was highlighted. The activated PAK1 showed dynamic expression and its subcellular localization was closely associated with spindle dynamics. Inhibition of PAK1 activity by IPA-3 led to impaired extrusion of PB1 and failure of bipolar spindle formation, which could be restored by reducing disulfide bonds between PAK1 and IPA-3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lina S. Hansson, John Axelsson, Predrag Petrovic, Sofie Paues Goranson, Mats J. Olsson, Mats Lekander, Julie Lasselin
Summary: This pilot study found that experimentally induced inflammation affects the cognitive reappraisal of emotions and suggests that disgust stimuli might be more difficult to reappraise than general negative stimuli.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Mats Koeneman, Rebecca Koch, Harry van Goor, Peter Pickkers, Matthijs Kox, Sebastian Bredie
Summary: In a controlled human model of systemic inflammation, elevations in the LF:HF ratio followed very shortly after elevations in plasma cytokine levels and preceded onset of flu-like symptoms and alterations in vital signs. HRV may represent a promising non-invasive tool for early detection of a developing systemic inflammatory response.
Article
Nutrition & Dietetics
Maike Mose, Niels Moller, Niels Jessen, Ulla Ramer Mikkelsen, Britt Christensen, Elin Rakvaag, Bolette Hartmann, Jens Juul Holst, Jens Otto Lunde Jorgensen, Nikolaj Rittig
Summary: In controlled catabolic conditions, dairy protein supplements BLG, CAS, and WHE have similar effects on muscle in young male participants. BLG showed specific, possibly GIP-dependent, insulinotropic properties, which may have future clinical implications.
JOURNAL OF NUTRITION
(2021)
Article
Immunology
Zhimin Zou, Li Li, Qin Li, Peng Zhao, Kun Zhang, Chengyong Liu, Daozhang Cai, Marc Maegele, Zhengtao Gu, Qiaobing Huang
Summary: Traumatic brain injury (TBI) is a major cause of disability and death. This study aimed to investigate the role of S100B and its receptor RAGE in mediating secondary injury after TBI. The results showed that TBI can activate the release of S100B, leading to the shedding of endothelial glycocalyx and increased vascular permeability, ultimately resulting in secondary brain and lung injury.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, General & Internal
Robert Ryczek, Przemyslaw J. Kwasiborski, Agnieszka Rzeszotarska, Jolanta Dymus, Agata Galas, Anna Kazmierczak-Dziuk, Anna M. Karasek, Marta Mielniczuk, Malgorzata Buksinska-Lisik, Jolanta Korsak, Pawel Krzesinski
Summary: Measurements of NSE and S100B at admission can accurately identify patients with poor clinical outcomes after OHCA with 100% specificity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mathilde Francin-Allami, Axelle Bouder, Audrey Geairon, Camille Alvarado, Lucie Le-Bot, Sylviane Daniel, Mingqin Shao, Debbie Laudencia-Chingcuanco, John P. Vogel, Fabienne Guillon, Estelle Bonnin, Luc Saulnier, Richard Sibout
Summary: Seeds of Brachypodium distachyon contain low levels of starch and high levels of MLG. MLG is degraded during germination and serves as the main carbohydrate source. The cslf6 mutants modify gene expression and adapt their metabolism to the absence of MLG, suggesting substrate-dependent regulation of storage sugars during germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Jia Liang, Hui Li, Chang-Dong Liu, Xiao-Yan Zhou, Yan-Yan Fu, Xiang-Yu Ma, Dan Liu, Yu-Ling Chen, Qian Feng, Zhen Zhang, Xiang-Ru Wen, Guang Zhu, Nan Wang, Yuan-Jian Song
Summary: The study shows that intervention of the interaction between S100b and Rage can treat ischemic stroke. The designed peptide, TAT-W61, can directly bind to S100b, reducing inflammation and improving pathological damage, as well as restoring cognitive and motor functions in animal models.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Leticia Rodrigues, Krista Mineia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: In this study, the researchers investigated the role of S100B, a neurotrophic protein, in brain injury and neuroregeneration. Using S100Btg mice with increased expression of the S100B gene, they found enhanced proliferation and migration of progenitor cells, as well as reduced levels of GFAP, ApoE, and BDNF in certain brain regions. The study highlights the importance of the S100Btg model in evaluating the role of S100B in neuroregenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Antonio J. Figueira, Joana Saavedra, Isabel Cardoso, Claudio M. Gomes
Summary: Extracellular aggregation of the amyloid-beta 1-42 peptide is a major characteristic of Alzheimer's disease (AD), and recent studies have shown that the intermediate oligomers of amyloid-beta are more cytotoxic than mature fibrils. In this study, the researchers investigated how different chaperone multimers of S100B, a signaling protein increased in AD, influence the formation of amyloid-beta oligomers. It was found that dimeric S100B-Ca2+ C drastically decreased the rate of oligomerization and levels of amyloid-beta oligomers, while tetrameric apo-S100B inhibited both oligomerization and fibril elongation. These findings highlight the potential neuroprotective role of different S100B multimers in AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biology
Yanzuo Liu, Yueming Hua, Kicheon Park, Nora D. Volkow, Yingtian Pan, Congwu Du
Summary: Human and animal studies have shown that chronic cocaine exposure can lead to widespread reductions in cerebral blood flow. However, the cellular and molecular mechanisms underlying these changes are not well understood. In this study, researchers used a multimodal imaging platform to simultaneously measure the effects of acute cocaine on neuronal and astrocytic activity, tissue oxygenation, hemodynamics, and vascular diameter changes in the mouse cerebral cortex. The results showed that cocaine constricted blood vessels, decreased cerebral total blood volume, and temporarily reduced tissue oxygenation. Cellular imaging revealed that cocaine-induced changes in astrocytic activity were weaker but longer-lasting than changes in neuronal activity. Inhibiting astrocytic activity attenuated the vasoconstriction caused by cocaine, suggesting that astrocytes play a critical role in mediating cocaine's effects on blood vessels in the brain. The findings of this study provide important insights into the cellular and vascular interactions induced by cocaine and have implications for potential treatments to reduce cerebrovascular pathology associated with cocaine use.
COMMUNICATIONS BIOLOGY
(2022)
Article
Microbiology
Alexander S. F. Berry, Meghann K. Pierdon, Ana M. Misic, Megan C. Sullivan, Kevin O'Brien, Ying Chen, Samuel J. Murray, Lydia A. Ramharack, Robert N. Baldassano, Thomas D. Parsons, Daniel P. Beiting
Summary: The study reveals that parity is an important factor modulating the gut microbiome during pregnancy, impacting the community of bacteria that colonize the offspring gut early in life, potentially influencing host metabolism. The results underscore the importance of considering parity in human microbiome studies during pregnancy and in infants.
Letter
Medicine, General & Internal
Jiaxin Ling, Rachel A. Hickman, Robert Frithiof, Michael Hultstrom, Josef D. Jarhult, Ake Lundkvist, Miklos Lipcsey
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Elisabeth Berghall, Michael Hultstrom, Robert Frithiof, Miklos Lipcsey, Victoria Hahn-Stromberg
Summary: This study found that patients with severe COVID-19, in addition to increased ILs, lymphopenia, and increased granulocytes, also had effects on the bone marrow.
Article
Nursing
Ing-Marie Larsson, Michael Hultstrom, Miklos Lipcsey, Robert Frithiof, Sten Rubertsson, Ewa Wallin
Summary: This study aimed to assess the burden of illness and impact on health and working situation among former intensive care patients treated for COVID-19. A prospective cohort study was conducted in Sweden, and the results showed that cognitive, physical, and psychological impacts were observed among the patients. Cognitive functions improved after 12 months, but no clear improvements were seen in physical or psychological outcomes. Higher burden of illness was associated with difficulty returning to work.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Anesthesiology
Karl Stattin, Robert Frithiof, Michael Hultstrom, Miklos Lipcsey, Rafael Kawati
Summary: The study investigated the relationship between the use of ICU resources and organ support and mortality in COVID-19 patients. It was found that pressure on ICU resources was associated with the use of mechanical ventilation, indicating that resources were prioritized for sicker patients. Other measures of resource pressure were not associated with organ support or mortality.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Anesthesiology
Anders O. Larsson, Michael Hultstrom, Robert Frithiof, Miklos Lipcsey, Ulf Nyman, Mats B. Eriksson
Summary: This study aimed to compare the application of creatinine-based and cystatin C-based methods for estimating glomerular filtration rate (GFR) in COVID-19 ICU patients. The results showed that creatinine-based eGFR estimations were higher than cystatin C-based estimations, which is of importance for determining drug dosage in COVID-19 patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Critical Care Medicine
Anna Bergstrom, Miklos Lipcsey, Anders Larsson, Bei Yang, David Engblom, Michelle S. Chew, Louise Elander
Summary: Acetaminophen attenuates the effects of endotoxin on pulmonary circulation in anesthetized pigs, delaying and reducing the rapid increase in pulmonary artery pressure and pulmonary vascular resistance induced by endotoxin infusion. It also reduces tachycardia and decreases stroke volume without affecting inflammatory parameters, potentially playing a role in severe systemic inflammation.
Article
Biochemistry & Molecular Biology
Sana Asif, Robert Frithiof, Anders Larsson, Stephanie Franzen, Sara Bulow Anderberg, Bjarne Kristensen, Michael Hultstroem, Miklos Lipcsey
Summary: Dexamethasone has been shown to decrease mortality in severe COVID-19 patients and is associated with altered immunological and physiologic responses. Patients treated with Dexamethasone had higher blood glucose but lower blood lactate, plasma cortisol, immunoglobulins, D-dimer, cytokines, syndecan-1, and E-selectin levels, and received less organ support. Early administration of Dexamethasone within 14 days of COVID-19 debut reduced the mortality risk by 40%.
Article
Medicine, General & Internal
Anja Linden, Jane Fisher, Gisela Lilja, Markus Harboe Olsen, Fredrik Sjovall, Marten Jungner, Martin Spangfors, Line Samuelsson, Jonatan Oras, Adam Linder, Johan Unden, T. Kander, Miklos Lipcsey, Niklas Nielsen, Janus C. Jakobsen, Peter Bentzer
Summary: This trial aims to test whether a protocol targeting non-resuscitation fluids can reduce fluid administration compared to usual care. The study design is a multicentre, randomised, feasibility trial, with adult ICU patients with septic shock as participants. The results will be submitted for publication in a peer-reviewed journal.
Article
Medicine, General & Internal
Philip A. Karlsson, Julia Parssinen, Erik A. Danielsson, Nikos Fatsis-Kavalopoulos, Robert Frithiof, Michael Hultstrom, Miklos Lipcsey, Josef D. Jarhult, Helen Wang
Summary: A longitudinal study in a Swedish ICU found that length of stay in the ICU is linearly correlated with the risk of bacteriuria. The high use of cefotaxime was associated with the prevalence of Enterococcus, which in turn allowed co-colonization by Gram-negative bacteria. These findings suggest that biofilms in urinary catheters may serve as reservoirs of pathogenic bacteria that can develop and disseminate antimicrobial resistance.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Silvia Marchesi, Elin Lundstrom, Hakan Ahlstrom, Miklos Lipcsey
Summary: Diffusion weighted magnetic resonance imaging (DW-MRI) can accurately assess edema and perfusion in abdominal organs. This technique has the potential for clinical use in septic patients.
Letter
Critical Care Medicine
Gunnar Strandberg, Miklos Lipcsey
INTENSIVE CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Havelka, Anders O. Larsson, Johan Martensson, Max Bell, Michael Hultstrom, Miklos Lipcsey, Mats Eriksson
Summary: This study evaluated the health and economic implications of using calprotectin as a predictive tool for initiating antibiotic therapy in critically ill patients. The results showed that using calprotectin predictively could reduce hospital stay and mortality rate, thus having a significant cost-saving and life-saving impact on the healthcare system.
Correction
Biochemistry & Molecular Biology
Elisabeth Berghall, Michael Hultstrom, Robert Frithiof, Miklos Lipcsey, Victoria Hahn-Stromberg
Article
Critical Care Medicine
Tomas Luther, Per Eckerbom, Eleanor Cox, Miklos Lipcsey, Sara Bulow, Michael Hultstrom, Francisco Martinez Torrente, Jan Weis, Fredrik Palm, Susan Francis, Robert Frithiof, Per Liss
Summary: In critically ill COVID-19 patients with AKI, total, cortical, and medullary renal blood flows were reduced compared to similar patients without AKI, while no differences in renal oxygenation were observed in this study.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Gunnar Antoni, Jens Sorensen, Mark Lubberink, Elin Lindstrom, Mathias Elgland, Olof Eriksson, Michael Hultstrom, Robert Frithiof, Anders Wanhainen, Jonathan Sigfridsson, Paul Skorup, Miklos Lipcsey
NUCLEAR MEDICINE AND BIOLOGY
(2022)