Article
Critical Care Medicine
Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuaki Koyama, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa, Kazuma Yamakawa
Summary: This study investigates the effects and safety of vasopressin loading in patients with septic shock, and finds that it can predict responses to its continuous infusion while being safe to use.
Article
Medicine, General & Internal
Kensuke Nakamura, Hidehiko Nakano, Hiromu Naraba, Masaki Mochizuki, Yuji Takahashi, Tomohiro Sonoo, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa, Kazuma Yamakawa
Summary: This study examined the effects of vasopressin loading followed by continuous administration in septic shock patients and found that loading may predict responses to continuous administration. However, further investigation involving safety analysis is needed.
FRONTIERS IN MEDICINE
(2021)
Review
Health Care Sciences & Services
Raquel Garcia-Alvarez, Rafael Arboleda-Salazar
Summary: This article reviews the use of vasopressin based on scientific evidence and clinical experience, and summarizes controversies surrounding its use in septic shock and other vasodilatory states.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Allergy
Guillaume Pouessel, Antoine Deschildre, Timothy E. Dribin, Ignacio J. Ansotegui, Victoria Cardona, R. Sharon Chinthrajah, Motohiro Ebisawa, Antonella Muraro, Graham Roberts, Hugh A. Sampson, Susan Waserman, Robert A. Wood, Margitta Worm, Paul J. Turner
Summary: Anaphylaxis reactions can range in severity, from mild respiratory involvement to life-threatening refractory reactions. The optimal approach to defining and grading the severity of severe reactions is still unclear. A new entity called refractory anaphylaxis (RA) has emerged, characterized by persistent anaphylaxis despite initial treatment with epinephrine. This article reviews the definitions, epidemiology, triggers, risk factors, and management strategies for RA, highlighting the need for consensus and improved understanding of this condition.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Steven Kulesza, Lindsey Gignac, C. Allis Colvin, Skyler Boll, Christopher Giuliano, Bradley Haan, Bryan Allen, Mary M. M. Perez, Monica Allen, Stephanie B. B. Edwin
Summary: There is significant practice variation in choosing between hydrocortisone and vasopressin as second line agents in septic shock patients. This study aimed to compare the clinical outcomes of these two agents.
Review
Medicine, General & Internal
Olfa Hamzaoui, Antoine Goury, Jean-Louis Teboul
Summary: Septic shock is characterized by vasoplegia and arterial hypotension, requiring vasopressor therapy. Norepinephrine is the first-line vasopressor, and vasopressin can be added in cases of inadequate mean arterial pressure. There are some unanswered questions regarding the use of these vasopressors, such as dose titration and escalation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Alexandria C. Rydz, Jessica L. Elefritz, Megan Conroy, Kathryn A. Disney, Christopher J. Miller, Kyle Porter, Bruce A. Doepker
Summary: The study suggests that early initiation of vasopressin in septic shock may reduce the risk of in-hospital all-cause mortality and/or organ dysfunction.
Review
Health Care Sciences & Services
Eleni Laou, Nikolaos Papagiannakis, Androniki Papadopoulou, Theodora Choratta, Minas Sakellakis, Mariachiara Ippolito, Ioannis Pantazopoulos, Andrea Cortegiani, Athanasios Chalkias
Summary: This systematic review and meta-analysis aimed to investigate the effects of vasopressin receptor agonists in the resuscitation of hemorrhagic shock. The results showed no significant correlation between the use of vasopressin receptor agonists and mortality or hemodynamic parameters. However, due to heterogeneity in animal studies, more data are needed to draw certain conclusions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Elisa Silvetti, Oreste Lanza, Fabiana Romeo, Annamaria Martino, Elisa Fedele, Chiara Lanzillo, Cinzia Crescenzi, Francesca Fanisio, Leonardo Calo
Summary: Cardiomyopathies are a group of diseases that affect the structure and function of the heart. Electrocardiogram (ECG) is a useful tool for diagnosing both symptomatic and asymptomatic individuals. Certain ECG findings, like inverted T waves in specific leads or low voltages, can be indicative of specific cardiomyopathies. Other non-specific findings, such as QRS fragmentation or changes in repolarization, can raise clinical suspicion and guide further imaging for a definitive diagnosis. These ECG alterations have prognostic value and can help in risk stratification. This review emphasizes the importance of ECG in the diagnostic workup of different cardiomyopathies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cell Biology
Albert Liu, Xiao Wang
Summary: mRNA therapeutics has matured into a potent modality, highlighted during the COVID-19 pandemic, but the full scope of potential modifications is yet to be explored clinically; Various types of mRNA modifications can tune the properties of mRNA, offering potential for diversifying future therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
A. S. Annie-Mathew, Subramanian Prem-Santhosh, Ravichandran Jayasuriya, Goutham Ganesh, Kunka Mohanram Ramkumar, D. V. L. Sarada
Summary: Adipose tissue plays a crucial role in maintaining metabolic homeostasis, but overnutrition can lead to abnormal increase in adipocytes, causing obesity and other chronic complications. Oxidative stress is closely involved in the pathogenesis of obesity, and the Nrf2 signaling pathway plays a significant role in regulating oxidative and inflammatory responses. Researchers are currently seeking novel compounds to modulate Nrf2 activity for the management of adipogenesis and obesity.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Maria Vittoria Barone, Renata Auricchio, Merlin Nanayakkara, Luigi Greco, Riccardo Troncone, Salvatore Auricchio
Summary: Celiac disease is an immune-mediated enteropathy triggered by gluten-containing cereals. Inflammation plays a central role in the pathogenesis of CD, and recent studies have shown that low-grade inflammation exists even without gluten. Pre-onset and pre-gluten introduction studies have revealed cellular and metabolic alterations without a T cell-mediated response. This review discusses the importance of inflammation in the natural history of CD, supported by cellular fragility and increased sensitivity to gluten and other pro-inflammatory agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Xujing Liu, Aihua Zhai, Bai Zhang
Summary: This case study discusses the anaphylactic shock caused by reexposure to exenatide after interruption of treatment. The study highlights the immunogenicity of exenatide and the importance of considering the possibility of anaphylactic shock in patients receiving exenatide treatment.
Article
Pediatrics
Chetan Khare, Bethou Adhisivam, B. Vishnu Bhat, Dheeraj Vaishnav
Summary: Low dose vasopressin may be beneficial as a rescue therapy for neonates with persistent pulmonary hypertension and catecholamine refractory shock in resource-limited settings. The initiation of low dose vasopressin resulted in improvements in oxygenation index, control of hypotension, reduction in lactic acidosis, and decreased need for inotropic support.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Chemistry, Multidisciplinary
Claire Donohoe, Fabio A. Schaberle, Fabio M. S. Rodrigues, Nuno P. F. Goncalves, Christopher J. Kingsbury, Mariette M. Pereira, Mathias O. Senge, Ligia C. Gomes-da-Silva, Luis G. Arnaut
Summary: The challenge of large molecules crossing cell membranes has hindered the development of new medicines. However, this study shows that altering the atropisomers of a drug can improve cell uptake and therapeutic efficacy. The most effective atropisomer is able to optimize hydrogen bonding with membrane phospholipids, leading to increased cellular uptake and phototoxicity. These findings highlight the importance of atropisomerism in drug development and provide new insights for designing efficient cell-penetrating drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Letter
Anesthesiology
W. Schummer
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Letter
Anesthesiology
W. Schummer
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Letter
Critical Care Medicine
Manuel F. Struck, Thomas Schmidt, Bernd E. Winkler, Konrad Reinhart, Wolfram Schummer
INTENSIVE CARE MEDICINE
(2015)
Article
Peripheral Vascular Disease
Manuel F. Struck, Thomas Schmidt, Bernd E. Winkler, Konrad Reinhart, Wolfram Schummer
JOURNAL OF VASCULAR ACCESS
(2016)
Letter
Emergency Medicine
Manuel F. Struck, Holger Staab, Wolfram Schummer, Udo Gottschaldt, Udo X. Kaisers, Joerg Schnoor
EUROPEAN JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Anesthesiology
Manuel F. Struck, Theresa Juenemann, Konrad Reinhart, Wolfram Schummer
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2017)
Article
Peripheral Vascular Disease
Manuel F. Struck, Sebastian Ewens, Wolfram Schummer, Thilo Busch, Michael Bernhard, Johannes K. M. Fakler, Patrick Stumpp, Sebastian N. Stehr, Christoph Josten, Hermann Wrigge
JOURNAL OF VASCULAR ACCESS
(2018)
Article
Anesthesiology
W. Schummer, O. Schlonski, M. Breuer
BRITISH JOURNAL OF ANAESTHESIA
(2014)
Article
Anesthesiology
W. Schummer, J. A. Koeditz, C. Schelenz, K. Reinhart, S. G. Sakka
BRITISH JOURNAL OF ANAESTHESIA
(2014)
Review
Critical Care Medicine
G. A. Schmidt, M. Blaivas, S. A. Conrad, F. Corradi, S. Koenig, M. Lamperti, B. Saugel, W. Schummer, M. Slama
INTENSIVE CARE MEDICINE
(2019)
Article
Multidisciplinary Sciences
Manuel Florian Struck, Lars Friedrich, Stefan Schleifenbaum, Holger Kirsten, Wolfram Schummer, Bernd E. Winkler
Article
Critical Care Medicine
Wolfram Schummer
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2018)
Article
Medicine, General & Internal
W. Schummer, A. Hottenrott, C. Nissel
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2018)
Article
Anesthesiology
A. Seifert, C. S. Hartog, J. Zweigner, W. Schummer, K. Reinhart
Letter
Critical Care Medicine
Wolfram Schummer
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2017)
