Article
Biochemistry & Molecular Biology
Dylan C. Sarver, Cheng Xu, Dana Carreno, Alexander Arking, Chantelle E. Terrillion, Susan Aja, G. William Wong
Summary: This study found that CTRP11, a member of the C1q/TNF-related protein family, is not essential for skeletal muscle development and testosterone production but plays a role in controlling sugar and fat metabolism. CTRP11 deficiency affects metabolic parameters, with increased fasting ketones and reduced physical activity observed in female mice. Moreover, CTRP11 deficiency exacerbates obesity-induced glucose intolerance, particularly in male mice.
Article
Emergency Medicine
Osman Adi, Farah Nuradhwa Apoo, Chan Pei Fong, Azma Haryaty Ahmad, Nurul Liana Roslan, Faheem Ahmed Khan, Shahridan Fathil
Summary: Bronchospasm is reversible constriction of bronchial tree smooth muscles, commonly seen in patients with acute exacerbation of asthma or chronic obstructive pulmonary disease. Ventilation may be difficult in mechanically intubated patients with severe bronchospasm due to airflow limitation. Inhaled volatile anesthetic gas has shown to have bronchodilation properties and can be considered as an alternative rescue therapy for ventilated patients with severe lower airway obstruction.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sarah Eagleman, M. Bruce MacIver
Summary: The use of multiple anesthetic and adjuvant agents during surgery can lead to different EEG responses, creating challenges for accurate EEG monitoring. Due to significant variations in electrophysiological responses to anesthetics at different age extremes, more testing for various drug combinations is required. Research should focus more on the generalized effects of anesthetic agents on network activity, to enhance universal analysis methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Sarah P. Shultz, Ashley N. Buck, Philip W. Fink, Stacey M. Kung, Mary J. Ward, Zoltan Antal, Sherry I. Backus, Andrew P. Kraszewski, Howard J. Hillstrom
Summary: This study compared knee moment asymmetry between adolescents with and without obesity and examined the relationship between asymmetries and inflammatory biomarkers. The results showed that adolescents with obesity had greater sagittal and frontal plane kinetic knee asymmetry and higher concentrations of interleukin-6 and C-reactive protein. This suggests that there is an increased risk to joint health in adolescents with obesity due to greater knee joint asymmetry and increased inflammatory response.
CLINICAL BIOMECHANICS
(2023)
Article
Biochemistry & Molecular Biology
Kevin Jahnke, Helmut Grubmueller, Maxim Igaev, Kerstin Goepfrich
Summary: This study demonstrates that the choice of fluorophore can strongly affect the reconfiguration of DNA nanostructures. Through a combination of experiments, simulations, and modeling, it is shown that different fluorophore combinations can alter DNA nanostructure formation, providing a strategy for designing dynamic DNA nanodevices.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Elisabetta Trevellin, Silvia Bettini, Anna Pilatone, Roberto Vettor, Gabriella Milan
Summary: Epidemiological observations, experimental studies and clinical data suggest that obesity is associated with an increased risk of developing various types of cancer. The adipose tissue alterations occurring in obesity could play a significant role in this association. The obesity-altered adipose tissue environment contributes to cancer development, progression, metastasis and chemoresistance through direct and indirect interactions involving different cellular types and molecular mechanisms.
Article
Biochemistry & Molecular Biology
Michael Forsthofer, Michael Schutte, Harald Luksch, Tobias Kohl, Lutz Wiegrebe, Boris P. Chagnaud
Summary: The rattlesnakes generate acoustic signals by clashing keratinous segments at the tip of their tails, creating a continuous signal recognized by other animals. As a potential threat approaches, the rattlesnakes increase their rattling rate, similar to sensors while parking a car, before abruptly switching to a higher rate. This change in rattling rate affects distance judgments by humans and acts as an interspecies communication signal.
Article
Food Science & Technology
Jordi Mayneris-Perxachs, Peter Meikle, Aya Mousa, Negar Naderpoor, Jose Manuel Fernandez-Real, Barbora de Courten
Summary: This study found that muscle carnosine supplementation has positive effects on plasma lipidome, and established the relationship of muscle carnosine and serum carnosinase-1 with cardiometabolic risk factors and lipid metabolism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ranim Mahmoud, Virginia Kimonis, Merlin G. Butler
Summary: Obesity is a disease caused by genetic and environmental factors, with increasing worldwide prevalence. The genetics of obesity can be classified into syndromic and non-syndromic obesity, with syndromic obesity associated with developmental delay and early onset obesity. Advances in genetic testing have helped identify obesity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Georgia Knight, Mary Mushambi
Summary: Obesity poses significant health risks for both mothers and fetuses, increasing morbidity and mortality. Obstetric anesthetists need to be equipped with knowledge and tools to manage these women effectively, using a multidisciplinary team approach and early planning. Neuraxial analgesia for labor can help reduce the need for general anesthesia and its associated risks.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Immunology
Larissa C. Engert, Janet M. Mullington, Monika Haack
Summary: Sleep disturbances, particularly insomnia symptoms, can significantly disrupt the resolution of inflammation, especially for resolvins of the D-series, and this effect can persist even after recovery sleep has been obtained. Sleep disturbances may have a long-term impact on the active resolution of inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Anna Permyakova, Ariel Rothner, Sarah Knapp, Alina Nemirovski, Danny Ben-Zvi, Joseph Tam
Summary: This study investigates the impact of obesity on the endocannabinoid system (ECS) in renal function, revealing that obese patients exhibit kidney damage, increased activity of endocannabinoid synthesizing and degrading enzymes, and reduced expression of cannabinoid-1 receptor (CB1R) in the kidney. The findings enhance our understanding of the intricate interplay among obesity, the ECS, and kidney function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Bhawakshi Punia, Srabanti Chaudhury, Anatoly Kolomeisky
Summary: Recent experiments have discovered catalytic cooperativity phenomenon, and our theoretical analysis predicts that heterogeneity in catalytic systems can increase the strength of cooperativity and decrease communication lifetimes and distances.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Ecology
Monica L. Bond, Barbara Koenig, Derek E. Lee, Arpat Ozgu, Damien R. Farine
Summary: Experimental evidence shows that giraffes in communities closer to traditional Masai compounds exhibit weaker social relationships and more exclusivity in social associations. Human presence may play a crucial role in determining the conservation future of this megaherbivore.
JOURNAL OF ANIMAL ECOLOGY
(2021)
Article
Psychology, Multidisciplinary
Paola Andrea Russo, Mirko Duradoni, Andrea Guazzini
Summary: Research on extending human-human interaction rules to artificial intelligence in computer-mediated communication is important, as artificial agents are widely present in daily life. An experiment on the Ultimatum Game showed that humans tend to apply real-life psychological dynamics even to artificial entities, with men and women showing different behaviors when reputation is attributed.
COMPUTERS IN HUMAN BEHAVIOR
(2021)