Article
Clinical Neurology
Jinseung Kim, Dong Ah Lee, Hyung Chan Kim, Ho-Joon Lee, Kang Min Park
Summary: This study investigated differences in cerebral blood flow and functional networks between transient global amnesia (TGA) patients with single and recurrent events using arterial spin labeling (ASL) MRI. The results showed that the eccentricity in functional network analysis was significantly higher in TGA patients with recurrent events compared to those with a single event, suggesting that TGA may be a network disease with functional network alterations related to clinical symptoms.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Review
Neurosciences
Ioannis Liampas, Maria Raptopoulou, Stefanos Mpourlios, Vasileios Siokas, Zisis Tsouris, Athina-Maria Aloizou, Metaxia Dastamani, Alexandros Brotis, Dimitrios Bogdanos, Georgia Xiromerisiou, Efthimios Dardiotis
Summary: This study revealed that patients with recurrent TGA have an earlier age of onset, and are associated with a family or personal history of migraine and depression. Weak evidence suggests a relationship between recurrence and family history of dementia, history of head injury, and hippocampal lesions in diffusion-weighted MRI. However, no connection was found between recurrence and electroencephalographic abnormalities, impaired jugular venous drainage, cardiovascular risk factors, atrial fibrillation, previous cerebrovascular events, exposure to precipitating events, family history of TGA, and hypothyroidism.
REVIEWS IN THE NEUROSCIENCES
(2021)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary memory disorder with unknown etiology. Current research focuses on the vascular, epileptic, and migraine-related mechanisms, as well as the vulnerability of CA1 neurons in the hippocampus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Renato Oliveira, Tomas Teodoro, Ines Bras Marques
Summary: Recurrence of transient global amnesia (TGA) is associated with female sex, history of depression, shorter episode duration, and hippocampal hyperintensity on brain MRI. History of depression was found to be the most important predictor of recurrence in our study.
NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a sudden onset memory disorder characterized by a temporary loss of memory for up to 24 hours, without any other neurological deficits. The diagnosis can be confirmed using Magnetic Resonance Imaging (MRI), although its practical utility in managing patients is still being debated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jaeho Kang, Dong Ah Lee, Ho-Joon Lee, Kang Min Park
Summary: There were no differences in limbic structure volumes between patients with TGA and healthy controls, but the radius of the limbic covariance network was significantly larger in TGA patients. Patients with recurrent TGA events showed alterations in various graph theory parameters compared to those with a single event.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Julian Santana, Carolina Garcia-Alfonso, Andrea Martinez, Andres Felipe Cardenas-Cruz, Maria Paula Aguilera-Pena, Oscar Bris-Fernandez, Alan Waich, Maria Del Mar Talero-Munoz, Juliana Coral
Summary: Transient global amnesia (TGA) is a clinical syndrome characterized by sudden anterograde amnesia without other neurological symptoms. This study identified a group of TGA patients with hippocampal ischemic lesions using brain MRI, and found that a high proportion of these patients had associated vascular risk factors. The most common risk factors were high blood pressure, carotid disease, and dyslipidemia.
NEUROLOGICAL SCIENCES
(2022)
Editorial Material
Behavioral Sciences
A. J. Larner
Summary: Recent authors claimed that Ribot described transient global amnesia in the 19th century, but a closer examination revealed discrepancies in understanding, as Ribot's references did not align with current knowledge of the condition.
Review
Clinical Neurology
Silvio Piffer, Stefania Nannoni, Francesco Maulucci, Valerie Beaud, Olivier Rouaud, Alex Foerster, Carlo W. Cereda, Philippe Maeder, Patrik Michel
Summary: This study analyzed the atypical clinical and radiological manifestations of patients with transient global amnesia (TGA) and/or hippocampal punctate diffusion-weighted imaging lesions (HPDL). The results showed that TGA may have atypical clinical manifestations, and patients with typical TGA may show disappearing extra-hippocampal punctate diffusion lesions. These findings contribute to better diagnosis of typical and atypical cases and stimulate further research.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Carolin Hoyer, Kyoko Higashida, Fabio Fabbian, Alfredo De Giorgi, Vesile Sandikci, Anne Ebert, Michael Platten, Shuhei Okazaki, Roberto Manfredini, Kristina Szabo
Summary: The study identified a robust circadian rhythm in the occurrence of TGA, with bimodal peaks each day, which was consistent across different study sites and independent of sex and age.
JOURNAL OF NEUROLOGY
(2022)
Article
Emergency Medicine
Edward Lee, Naila Ghafoor, Mohamed Jefri, Aislinn D. Black, Diane P. Calello, Cynthia D. Santos
Summary: This case report describes a patient without a cardiac history who was diagnosed with acute coronary syndrome and transient global amnesia after taking oral sumatriptan. The vasoconstrictive effects of sumatriptan can lead to cardiac and cerebral ischemic events, highlighting the importance of recognizing its toxic effects and adverse reactions in emergency medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Behavioral Sciences
Andrew J. Larner
Summary: Transient global amnesia (TGA) is a rare neurological disorder characterized by acute self-limited anterograde amnesia and variable retrograde amnesia. Although the clinical features, neuroimaging, prognosis, and triggering factors of TGA have been well described, the pathogenesis is currently not understood.
Article
Clinical Neurology
Vesile Sandikci, Anne Ebert, Lea Zurwesten, Michael Platten, Kristina Szabo, Carolin Hoyer
Summary: This study found that a small subgroup of TGA patients showed subtle performance reductions in different cognitive domains during the first days after an attack, especially in tests of verbal long-term memory and executive function. Patients with hippocampal diffusion-weighted imaging (DWI) lesions performed significantly worse in a verbal recognition task.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Keun-Hwa Jung, Da-jin Kang, Woo-Jin Lee, Hyo-Shin Son, Sohyun Kim, Seung Wan Kang
Summary: This study aims to investigate the pathophysiological changes underlying transient global amnesia (TGA) by exploring brain activities. The results showed significant changes in EEG power spectra and network analysis in TGA patients. They exhibited a global decrease in absolute power, a decrease in alpha waves, an increase in theta waves, and atypical compensation activity. These changes were observed regardless of symptom duration, EEG timing after onset, and cytotoxic lesions on MRI. In addition, network analysis showed higher activation in TGA compared to normal controls.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Jed A. Barash, Megha Parikh, Rosa Ergas, Alfred DeMaria Jr
Summary: By analyzing data from the Massachusetts Department of Public Health Syndromic Surveillance program, it was found that opioid use is not a risk factor for transient global amnesia (TGA) during emergency department visits, indicating that opioid-associated amnestic syndrome (OAS) and TGA are distinct entities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
