Article
Biochemistry & Molecular Biology
Yulia Michailov, Ali AbuMadighem, Eitan Lunenfeld, Joseph Kapelushnik, Mahmoud Huleihel
Summary: The study indicates that AML and CYT treatment have a significant negative impact on male fertility, but GCSF injection can improve this damage, restore spermatogenesis and fertility, showing potential value in preserving/restoring fertility in leukemia patients undergoing chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ming-Feng Liao, Shin-Rung Yeh, Kwok-Tung Lu, Jung-Lung Hsu, Po-Kuan Chao, Hui-Ching Hsu, Chi-Hao Peng, Yun-Lin Lee, Yu-Hui Hung, Long-Sun Ro
Summary: G-CSF treatment can attenuate neuropathic pain by modulating autophagic and apoptotic activity in CCI rats. Early upregulation of autophagy and late suppression of apoptosis contribute to the treatment of neuropathic pain.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Takamatsu, Kotaro Yoshida, Fumihito Toshima, Kazuto Kozaka, Naho Yamamoto, Yoshimichi Sai, Toshifumi Gabata
Summary: This study aims to clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. The results of the study found that the incidence of pegfilgrastim-induced aortitis may be higher than previously reported and may be more common in patients with esophageal cancer and those who received specific anticancer drugs. Furthermore, CT findings indicated that pegfilgrastim-induced aortitis is often characterized by involvement of the aortic arch and proximal branches.
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Vincenzo Adamo, Lorenzo Antonuzzo, Marco Danova, Michelino De Laurentiis, Paolo Marchetti, Carmine Pinto, Giovanni Rosti
Summary: This study aims to improve adherence to guideline recommendations for the prevention of febrile neutropenia and to enhance patient care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Yosuke Dotsu, Hiroyuki Yamaguchi, Minoru Fukuda, Takayuki Suyama, Noritaka Honda, Yasuhiro Umeyama, Hirokazu Taniguchi, Hiroshi Gyotoku, Shinnosuke Takemoto, Ryuta Tagawa, Ryosuke Ogata, Hiromi Tomono, Midori Shimada, Hiroaki Senju, Katsumi Nakatomi, Seiji Nagashima, Hiroshi Soda, Hiroaki Ikeda, Kazuto Ashizawa, Hiroshi Mukae
Summary: This study examined the real-world incidence of febrile neutropenia among patients with thoracic malignancies treated with single-agent amrubicin chemotherapy, and found that the incidence rate was 30%. It suggests that prophylactic G-CSF should be administered during practical use of this chemotherapy regimen for patients who have already undergone chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Toxicology
Woong-Il Kim, Je-Oh Lim, So-Won Pak, Se-Jin Lee, In-Sik Shin, Changjong Moon, Jeong-Doo Heo, Jong-Choon Kim
Summary: This study investigated the potential effects of China dust exposure on cyclophosphamide-induced testicular toxicity in mice, and found that the exposure to China dust exacerbated the testicular toxicity induced by cyclophosphamide, possibly due to the induction of lipid peroxidation and reduced antioxidant activity.
TOXICOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Manh-Hung Do, Hien Duong Thanh, Phuong Kim To, Min Soo Kim, Changjong Moon, Chaeyong Jung
Summary: This study investigated the effects of cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), on bladder cancer cells and its relationship with CD46. The findings suggest that CD46 plays a role in protecting bladder cancer cells from cetuximab-mediated inhibition and enhancement of immunologic anti-tumor effects.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Eunjin Cho, Xiangguo Che, Mary Jasmin Ang, Seongmin Cheon, Jinkyung Lee, Kwang Soo Kim, Chang Hoon Lee, Sang-Yeop Lee, Hee-Young Yang, Changjong Moon, Chungoo Park, Je-Yong Choi, Tae-Hoon Lee
Summary: Peroxiredoxin 5 (Prdx5) plays a significant role in regulating bone resorption and bone formation, and its deficiency leads to osteoporosis. Through immunoprecipitation and LC-MS/MS analysis, hnRNPK was identified as an interacting partner of Prdx5, and Prdx5 negatively regulates the expression of osteocalcin mediated by hnRNPK. Additionally, the loss of Prdx5 enhances the expression of osteoclast-related genes during the differentiation of bone marrow-derived macrophages into multinucleated osteoclasts. These findings suggest that Prdx5 plays an important role in maintaining bone homeostasis by regulating bone cell differentiation.
Article
Medicine, Research & Experimental
Gyeong Min Lim, Gwang-Won Cho, Chitra Devi Ganesan, Ji Hyun Choi, Mary Jasmin Ang, Changjong Moon, Chul Ho Jang
Summary: This study found that placental extract (PE) can increase the survival and migration ability of nerve cells and promote the expression of neurotropic genes. Treatment with PE improved the recovery of crushed facial nerves in rats, reduced the threshold of action potential, and showed larger axons and thicker myelin sheaths. Therefore, PE may be considered as a topical therapeutic agent for treating traumatic facial nerve paralysis.
EXPERIMENTAL NEUROBIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Anji Song, Gwang-Won Cho, Changjong Moon, Ilyong Park, Chul Ho Jang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Sohi Kang, Yeonghoon Son, In-Sik Shin, Changjong Moon, Min Y. Lee, Kyung S. Lim, Su-Jin Park, Chang-Geun Lee, Wol S. Jo, Hae-June Lee, Joong S. Kim
Summary: Inflammatory bowel diseases can be diagnosed through diagnostic imaging, but radiation exposure in the intestine can worsen the progression of these diseases. To study the impact of radiation on bowel diseases, mice were induced with colitis and exposed to abdominal irradiation. The results showed that abdominal irradiation aggravated the effects of colitis, including decreased survival rate, body weight, and colon length, as well as increased inflammation levels and expression of inflammatory genes. This study provides valuable insights for patients with inflammatory bowel diseases.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Toxicology
Heung-Sik Seo, Jun-Ho Kim, Sang-Ho Kim, Myeong-Kyu Park, Nak-Won Seong, Geun-Hee Kang, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Changjong Moon
Summary: There were no treatment-related adverse effects observed in rats that received repeated oral doses of CPSS over 90 days. The CPSS showed no toxicity in terms of clinical signs, body weight, food consumption, detailed clinical observation, sensory reactivity, functional assessment, urinalysis, ophthalmic examination, gross pathology, hematology, serum biochemistry, hormone analysis, organ weight, and histopathology.
TOXICOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Sungmoo Hong, Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Changjong Moon, Taekyun Shin
Summary: This study used RNA-sequencing to analyze the transcriptomes of retinas in mice with EAE and identified differentially expressed genes (DEGs) related to EAE-induced visual impairment. Gene expression analysis showed that the upregulated genes in the retinas of mice with EAE were primarily associated with immune responses and immune-mediated inflammation. In addition, gene set enrichment analysis revealed a negative enrichment of gene sets related to the neuronal system and phototransduction cascade in EAE-affected retinas. This study provides novel molecular evidence for visual impairments in EAE and indicates directions for further research to elucidate the mechanisms of these visual impairments in MS.
ANIMAL CELLS AND SYSTEMS
(2023)
Review
Environmental Sciences
Jeongmin Lee, Poornima D. E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon
Summary: This article reviews the neurotoxicity of particulate matter (PM) and its impact on neurodegenerative diseases. Epidemiological and animal model studies have provided some mechanistic insights. The review highlights the effects of PM exposure on the central nervous system and identifies research gaps and future directions. The findings presented in this review are important for informing public health policies and the development of new treatments for neurodegenerative diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Jae Min Kim, Sam Seok Cho, Sohi Kang, Changjong Moon, Ji Hye Yang, Sung Hwan Ki
Summary: This study investigated the anti-inflammatory effects of the 70% ethanol extract of Castanopsis sieboldii (CSL3) leaf. The results showed that CSL3 inhibited NO release and iNOS expression in LPS-stimulated cells, and antagonized NF-κB and AP-1 activation through MAPK inhibition. CSL3 also decreased NLRP3 inflammasome activation and increased IL-1β expression. In addition, CSL3 protected against acute liver injury by inhibiting inflammasome formation and pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sohi Kang, Hyun-Yong Kim, A. Yeong Lee, Hyo Seon Kim, Jun Hong Park, Byeong Cheol Moon, Hyeon Hwa Nam, Sung-Wook Chae, Bokyung Jung, Changjong Moon, In Sik Shin, Joong Sun Kim, Yun-Soo Seo
Summary: In this study, the effects of Camellia sinensis extract on ovalbumin-induced allergic asthma were evaluated. The results showed that the extract had anti-inflammatory and antioxidant activities, and could suppress the progression of asthma.
Article
Cell Biology
Bohye Kim, Joong-Sun Kim, Buhyun Youn, Changjong Moon
Summary: This study found that dopamine depletion in rats leads to increased plasticity-related signaling in the hippocampus. This may be a compensatory mechanism that promotes activity-independent neuroplasticity following dopamine depletion.
ANIMAL CELLS AND SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Jeongmin Lee, Poornima D. E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Chul Ho Jang, GyeongMin Lim, GwangWon Cho, Changjong Moon, Chitra Devi Ganesan, Mary Jasmin Ang
TISSUE ENGINEERING PART A
(2022)
Article
Veterinary Sciences
Sungwoong Jang, Bohye Kim, Jeongmin Lee, Sohi Kang, Joong-Sun Kim, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin, Changjong Moon
Summary: This study examined the histological characteristics and glycoconjugate composition of the olfactory mucosa (OM) in Korean native cattle. The findings suggest that glycoconjugates may play a role in olfactory chemoreception, and their labeling properties may be closely related to OM development and maturity.
JOURNAL OF VETERINARY SCIENCE
(2022)
