Article
Nanoscience & Nanotechnology
Meihui Yin, Min Yang, Daoping Yan, Lijiao Yang, Xiaohui Wan, Jipeng Xiao, Yongchao Yao, Jianbin Luo
Summary: In this study, a novel gold-nanorod-based chemo-photothermal-integrated antimicrobial platform was developed, which exhibited surface-charge-switchable and near-infrared-induced size-transformable activities. This platform showed enhanced killing efficiency against multidrug-resistant bacteria and their biofilms, particularly methicillin-resistant Staphylococcus aureus (MRSA) infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jinlan Li, Xin Yu, Jianing Zhang, Nan Yan, Jing Jin, Wei Jiang
Summary: This paper studied the entropy-driven formation of binary superlattices assembled from polymer-tethered nanorods and nanospheres. The results indicated that the conformational entropy of the polymer chains and the mixing entropy of the nanorods and nanospheres are two parameters that determine the formation of binary superlattices.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Jesus E. Marquez-Castro, Angel Licea-Claverie, Jacob Licea-Rodriguez, Leidy P. Quiroga-Sanchez, Eugenio R. Mendez
Summary: A series of diblock copolymers containing a biocompatible PEG block and a thermoresponsive PNVCL-based block were synthesized by RAFT polymerization. The cloud point temperature (Tcp) was adjusted from 35 to 42 degrees C by adding NVP units in the thermoresponsive block. The gold nanorods were stabilized with the copolymers through grafting, and the temperature-dependent aggregation of the copolymer@GNRDs has potential applications in drug-delivery for photothermal therapy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Baljinder Singh, Nutan Shukla, Junkee Kim, Kibeom Kim, Myoung-Hwan Park
Summary: This study focuses on the development of a on-demand drug delivery system using NIR-responsive nanofibers containing GNRs and PNIPAM. The system allows controlled drug release through thermal responses, with potential for combination chemotherapy and good biocompatibility. The versatility of the platform was confirmed in cell studies, demonstrating the advantages of the nanofibers' properties in drug delivery.
Article
Chemistry, Multidisciplinary
Yoon Ho Roh, Ji Yeon Eom, Dae Gun Choi, Ju Yeon Moon, Min Suk Shim, Ki Wan Bong
Summary: Thermoresponsive polymers incorporated with photo-absorbing agents are widely used for controlled drug delivery using light as an external stimulus. The study successfully synthesized gold nanorods-encapsulated PVCL microparticles using the stop-flow lithography method, achieving NIR light-responsive anticancer hyperthermia drug release.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xiao-Feng Pan, Huai-Ling Gao, Kai-Jin Wu, Si-Ming Chen, Tao He, Yang Lu, Yong Ni, Shu-Hong Yu
Summary: By selecting aramid nanofibers and mica microplatelets as building blocks, a nacreous aramid-mica bulk material with low density, high strength, and toughness was produced, showing impressive mechanical stability in harsh environments. It outperforms other nacre-mimetics and most engineering structural materials in terms of specific strength and toughness, making it a promising engineering structural material for various technical fields.
Review
Pharmacology & Pharmacy
Ling Zhou, Huiguo Liu, Kui Liu, Shuang Wei
Summary: Gold compounds have shown promising results in cancer therapy by interacting with the immune system, inducing innate immune responses and promoting adaptive immune responses to support anti-tumor immune responses. Gold nanoparticles have the potential to improve the effectiveness of immunotherapy and reduce the toxicity and side effects of treatment processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Nouran Rezk, Abdallah S. Abdelsattar, Salsabil Makky, Assmaa H. Hussein, Azza G. Kamel, Ayman El-Shibiny
Summary: This study biosynthesized Au-Ag nanoparticles using propolis and examined their antibacterial activity against antibiotic-resistant bacteria as well as their anticancer activity. The results showed that these nanoparticles exhibited antibacterial activity against various bacteria and had a cytotoxic effect on HEPG2 cells.
Article
Pharmacology & Pharmacy
Samaneh Mohammadian, Amir Avan, Majid Khazaei, Parvaneh Maghami
Summary: The study investigated the potential use of 5-fluorouracil-loaded ZnO nanocomposites (5-FU/Gd-ZnO NCs) for cancer treatment. Characterization of the materials revealed plate-like agglomeration with particle diameters ranging from 317.6 to 120.1 nm. The nanocomposites demonstrated inhibitory effects on cell growth and were able to reduce inflammatory markers and oxidative stress. In vivo experiments showed similar characteristics to free medication, indicating the potential of these nanocomposites as therapeutic agents.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Acoustics
Bharat Bhargawa, Varsha Sharma, Munuswamy-Ramanujam Ganesh, Francesca Cavalieri, Muthupandian Ashokkumar, Bernaurdshaw Neppolian, Anandhakumar Sundaramurthy
Summary: We present a novel approach using gold nanorods to encapsulate and release an anticancer drug, 5-fluorouracil, in lysozyme microspheres. The drug release from the encapsulated microspheres was enhanced under ultrasound irradiation, resulting in excellent anticancer activity.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Engineering, Biomedical
Xiang Liu, Qi Su, Huijuan Song, Xiaoguang Shi, Yuming Zhang, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Summary: The study demonstrates that PTT-induced in situ vaccination cancer therapy can effectively combat disseminated and metastatic tumors, showing promising anti-tumor immunity in mice. The use of gold nanorods covalently coupled with polyTLR7/8a and MMP-2-sensitive R9-PEG resulted in the formation of nanovaccines directly in vivo, activating dendritic cells and enhancing antitumor T-cell responses. Peritumoral administration of low-dose multifunctional AuNRs followed by noninvasive NIR laser irradiation inhibits local and distant metastatic tumors in mice, suggesting a potent therapeutic strategy for advanced cancers.
Article
Materials Science, Biomaterials
Yi Zhang, Siyuan Hao, Jingjie Zuo, Huiling Guo, Mingxing Liu, Hongda Zhu, Hongmei Sun
Summary: In this study, actively loaded doxorubicin (DOX) and gold nanorod (GNR) liposomes were engineered by embedding stiff hollow mesoporous silica nanoparticles (HMSNs) to prevent drug leakage and trigger DOX release through photothermal conversion of GNRs. The results showed that low concentration of HMLGDB effectively inhibited MCF-7 cell growth and caused minimal damage to normal tissues.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Shenglei Hou, Yuan Zhang, Meng Lian, Xin Xie, Qinghua Lu, Qiqing Zhang
Summary: Here, we present a multifunctional nanodrug (Au NRs@DSFDSs NPs) that combines drug self-framework delivery system (DSFDS) on Au NRs with absorption at 1300 nm through simple condensation polymerization. The aim is to develop an efficient theranostic nanoagent with multi-modal imaging ability and synergistic chemo-photothermal therapy (CT-PTT) for tumor growth monitoring and suppression. This strategy offers a new idea for the design of a multifunctional platform for accurate and effective image-guided tumor treatment.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Longbao Zhu, Zhao Kuang, Ping Song, Wanzhen Li, Lin Gui, Kai Yang, Fei Ge, Yugui Tao, Weiwei Zhang
Summary: Ruthenium(II) polypyridyl complexes exhibit high anti-tumor activity but face challenges such as poor solubility and low biocompatibility. In this study, gold nanorods modified thermosensitive liposomes were developed to encapsulate and release Ru precisely at the tumor site, enhancing the anti-tumor effect and photothermal therapeutic properties. The nanosystem showed significant inhibition of tumor growth with minimal side effects, indicating its potential for further research in anti-tumor activity.
Article
Pharmacology & Pharmacy
Yifang Wu, Mengmeng Wang, Yufan Li, Hongmei Xia, Yongfeng Cheng, Chang Liu, Ying Xia, Yu Wang, Yan Yue, Xiaoman Cheng, Zili Xie
Summary: Formulating docetaxel (DTX) in a slow-release emulsion with good stability prepared through self-assembly and high-speed electric stirring presents challenges but promising results in terms of controlled release. The addition of DTX in different phases of the emulsion affects its in vitro release rates and demonstrates antioxidant potential.