Article
Agronomy
Arwa A. Al-Huqail, Adnan A. Bekhit, Hammad Ullah, Muhammad Ayaz, Nada M. Mostafa
Summary: This study identified compounds in marigold flower extract and evaluated their potential as anti-leishmanial and anti-malarial agents. The results showed that marigold flowers are rich in flavonoids and have antibacterial effects against certain diseases.
Article
Biochemistry & Molecular Biology
Wataru Kadowaki, Ryo Miyata, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa
Summary: The study found that Calendula officinalis leaves contain 10 compounds with inhibitory activities against neurotransmitter-related diseases, particularly Parkinson's disease and depression.
Article
Chemistry, Applied
Reham M. Samra, Galal T. Maatooq, Ahmed A. Zaki
Summary: The newly isolated phytoconstituent (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) from Calendula officinalis showed potential leishmanicidal and antiprotozoal activities with no cytotoxicity against THP1 cells, indicating selectivity and safety.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Nelofer Jan, Umer Majeed, Mubashir Ahmad Wani, Zubair Ahmad Wani, Niranjan Chakraborty, Riffat John
Summary: This study investigated the cold stress tolerance mechanism in C. officinalis by analyzing its physiological dimensions and proteomic alterations. It was found that the plant can maintain cell turgidity and photosynthetic activity during cold stress, and protect itself from oxidative damage through the accumulation of antioxidants. Three unique proteins were identified to play a crucial role in cold tolerance mechanism. This first proteomic study on C. officinalis in response to cold stress provides valuable insights into understanding the mechanism of cold tolerance in ornamental plants.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Review
Chemistry, Medicinal
Kiran Shahane, Madhuri Kshirsagar, Srushti Tambe, Divya Jain, Srutee Rout, Maria Karolina Martins Ferreira, Suraj Mali, Purnima Amin, Prem Prakash Srivastav, Jorddy Cruz, Rafael Rodrigues Lima
Summary: Calendula officinalis Linn. is a popular medicinal plant with multifaceted biological effects, including anti-inflammatory, anti-cancer, antidiabetes, and wound healing activities. Recent research has explored its therapeutic applications, molecular mechanisms, and clinical studies, providing possibilities for validating traditional claims and advancing its safe and effective use.
Article
Agriculture, Multidisciplinary
Martina Garaiova, Qiang Hua, Roman Holic
Summary: By co-expressing C. officinalis fatty acid conjugases (CoFADX-1 or CoFADX-2) and Punica granatum fatty acid desaturase (PgFAD2), we successfully engineered the synthesis of calendic acid (CA) in the yeast Schizosaccharomyces pombe without the need for linoleic acid (LA) supplementation. The highest CA titer achieved was 4.4 mg/L, with an accumulation of 3.7 mg/g of DCW in the PgFAD2 + CoFADX-2 recombinant strain cultivated at 16 degrees C for 72 h. This study provides a valuable tool for identifying the essential components needed to produce CA as a high-value conjugated fatty acid at an industrial scale.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Horticulture
Nasibeh Pourghasemian, Rooholla Moradi, Marcello Iriti
Summary: Beeswax waste, as a novel biostimulant, has a similar anti-transpiration effect to chitosan. It can enhance plant yield and physiological traits, and reduce membrane permeability.
SCIENTIA HORTICULTURAE
(2023)
Article
Polymer Science
Wen-Hsin Huang, Chia-Yi Hung, Pao-Chang Chiang, Hsiang Lee, I-Ting Lin, Pin-Chuang Lai, Ya-Hui Chan, Sheng-Wei Feng
Summary: This study presents a CMC/PVA composite film incorporating Calendula officinalis extract for biomedical applications. The effects of different concentrations of the extract on the morphological, physical, mechanical, hydrophilic, biological, and antibacterial properties of the composite film are investigated. The addition of Calendula officinalis extract significantly affects the surface morphology, tensile strength, elongation, contact angle, non-cytotoxicity, and antimicrobial ability of the CMC/PVA composite film.
Article
Biochemistry & Molecular Biology
Aiste Balciunaitiene, Viktorija Puzeryte, Vitalijs Radenkovs, Inta Krasnova, Patrick B. Memvanga, Pranas Viskelis, Paulina Streimikyte, Jonas Viskelis
Summary: This study explores the usage of silver nanoparticles synthesized using aqueous plant extracts as reducing and capping agents for various bacterial problems. The nanoparticles showed strong antimicrobial and antioxidative activities compared to the plant extracts used for their synthesis. The size of the nanoparticles varied depending on the plant extract used. The findings highlight the potential of using these biosynthesized nanoparticles as a platform to combat pathogenic bacteria.
Article
Plant Sciences
Vahid Tavallali, Nasrin Alhavi, Hossein Gholami, Faezeh Mirazimi Abarghuei
Summary: This research investigates the impact of foliar polyamine spray on the growth, photosynthetic indices, secondary metabolites, and antioxidant activity of pot marigold. The results show that polyamine spray, especially spermidine, significantly enhances morphological and photosynthetic parameters, increases total oil and phenolic/flavonoid content, and improves antioxidant capacity. Additionally, polyamine application increases the abundance of sesquiterpene hydrocarbons in essential oils and carotenoids in flowers, indicating potential applications in the pharmaceutical industry.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Agronomy
Gulzar Akhtar, Hafiz Nazar Faried, Kashif Razzaq, Sami Ullah, Fahad Masoud Wattoo, Muhammad Asif Shehzad, Yasar Sajjad, Muhammad Ahsan, Talha Javed, Eldessoky S. Dessoky, Nader R. Abdelsalam, Muhammad Sohaib Chattha
Summary: Chitosan foliar application improves growth, photosynthetic pigments, and antioxidant enzyme activity in calendula under water stress conditions.
Article
Engineering, Environmental
Sandeep Kumar, K. K. Singh
Summary: Recently, rain gardens have become one of the best practices in cities to reduce urban flooding. However, little is known about the design parameters of rain gardens, such as the type of planting and dimensions. This study examines the influence of planting mixtures on the percolation rates of rain gardens with and without the Calendula officinalis plant. The results show that the percolation rate increases with a higher percentage of compost in the planting mixture, and no runoff is produced in rain gardens with a compost of more than 20% in the planting mixture.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Maria Doligalska, Kinga Jozwicka, Ludmila Szewczak, Julita Nowakowska, Klaudia Brodaczewska, Katarzyna Gozdzik, Cezary Paczkowski, Anna Szakiel
Summary: The study shows that triterpenoid saponins can alter the subcellular morphology of parasitic nematode larvae and affect the recognition of immunogenic proteins, leading to changes in proteins involved in signaling and cellular processes. Several candidate proteins, including beta-tubulin, myosin, actin, and ATP-synthase, were found to be downregulated or degraded in larvae exposed to saponins.
Review
Polymer Science
Marta S. Carvalho, Joaquim M. S. Cabral, Claudia L. da Silva, Deepak Vashishth
Summary: Engineering biomaterials that mimic the extracellular matrix of bone is crucial for bone tissue engineering applications. While collagen is known to be critical for bone tissue regeneration, the potential effects of non-collagenous proteins remain understudied. Incorporating non-collagenous proteins into scaffolds can enhance their performance and lead to the development of improved biomimetic bone materials.
Article
Multidisciplinary Sciences
Liangsong Zeng, Fengkai Liu, Qifeng Yu, Chenyu Jin, Jian Yang, Zhigang Suo, Jingda Tang
Summary: Bovine pericardium (BP) has been found to possess flaw-insensitive fatigue resistance as leaflets of prosthetic heart valves, due to the high strength of collagen fibers and soft matrix between them. The endurance strength of BP is unaffected by cuts up to 1 centimeter, while synthetic materials like thermoplastic polyurethane (TPU) fail at much shorter lengths. These findings could potentially contribute to the development of flaw-insensitive fatigue resistant soft materials.
Article
Anatomy & Morphology
Stella Aparecida de Andrade Pinto, Francisco Jose de Nadai Dias, Guinea Brasil Camargo Cardoso, Arnaldo Rodrigues dos Santos Junior, Andrea Aparecida de Aro, Danilo Siqueira Pino, Damaris Helena Meneghetti, Rafael Pino Vitti, Glaucia Maria Tech dos Santos, Cecilia Amelia de Carvalho Zavaglia
Summary: The study found that the 5% and 10% PCL/β-TCP scaffolds showed promising results in repairing critical bone defects in the calvaria of Wistar rats, by modulating inflammation, angiogenesis, fibroplasia, and collagenosis.
CELLS TISSUES ORGANS
(2022)
Article
Biochemical Research Methods
Cecilia do Amparo Manoel, Samara de Sousa Mariano, Ericsson da Silva Ramos, Fernanda Rossi Paolillo, Andrea Aparecida de Aro, Carolini Mendes, Ligia Milanez Venturini, Paulo Cesar Lock Silveira, Vanderlei Salvador Bagnato, Thiago Antonio Moretti de Andrade
Summary: PBM and PDT have been found to be effective in treating skin lesions caused by electrocautery, reducing scarring and promoting tissue repair. These therapies work by controlling inflammation and oxidative stress, and promoting angiogenesis and collagen formation.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Pharmacology & Pharmacy
Leila Regina Giarola, Julia Cedran Coco, Ilza Maria de Oliveira Sousa, Leticia Caramori Cefal, Janaina Artem Ataide, Guilherme Diniz Tavares, Rodney Alexandre Ferreira Rodrigues, Mary Ann Foglio, Priscila Gava Mazzola
Summary: This study evaluated the stability of microencapsulated extract of Pterodon pubescens and compared it with non-encapsulated extract. The gel containing 2.5% non-encapsulated extract showed the best stability under storage at 25 degrees C protected from light for 180 days. The extract of P. pubescens can be delivered through the gel.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Anatomy & Morphology
Alexandre Veronez, Leticia Albertini Pires, Andrea Aparecida de Aro, Maria Esmeria Corezola do Amaral, Marcelo Augusto Marretto Esquisatto
Summary: The study found that physical exercise in water has a positive effect on the structural organization and chemical composition of fibrocartilage in the tendons of diabetic rats, helping to preserve tendon structure.
Article
Anatomy & Morphology
Damaris Helena Meneghetti, Leonardo Bagne, Stella Aparecida de Andrade Pinto, Cecilia Amelia de Carvalho Zavaglia, Maria Esmeria Corezola Amaral, Marcelo Augusto Maretto Esquisatto, Glaucia Maria Tech Dos Santos, Thiago Antonio Moretti de Andrade, Milton Santamaria, Guilherme Ferreira Caetano, Andrea Aparecida de Aro, Fernanda Aparecida Sampaio Mendonca
Summary: The combination of electrical stimulation and bone tissue engineering has been successful in bone regeneration. This study found that electrical stimulation combined with PCL + beta-TCP 5% scaffolds can control inflammation, promote blood vessel proliferation, and osteogenesis, making it a potentially promising strategy for bone defects regeneration.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Anatomy & Morphology
Beatriz Calloni Masiero, Bruno Calsa, Camila Andreia Oliveira, Thiago Antonio Moretti de Andrade, Marcelo Augusto Marretto Esquisatto, Rosana Catisti
Summary: Cardiovascular diseases affect a large part of the population during adulthood. This study demonstrates an association between maternal protein restriction and the risk of developing heart disease in offspring. The effects of protein restriction on the cardiac muscles are sex-specific, with male offspring showing oxidative stress, hypertrophy, and signs of tissue inflammation.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Chemistry, Applied
Nathan H. Noguera, Dyana C. Lima, Jose Claudio Klier Monteiro Filho, Rodney A. F. Rodrigues
Summary: Microparticles loaded with rice bran oil were produced using rice co-products as stabilizers, improving emulsion stability and particle properties while slowing down autooxidation. This study aligns with current trends in sustainability.
JOURNAL OF MICROENCAPSULATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bruno Calsa, Taina Jaqueline Bortolanca, Beatriz Calloni Masiero, Marcelo Augusto Marretto Esquisatto, Camila Andrea de Oliveira, Rosana Catisti, Milton Santamaria-Jr
Summary: Maternal protein restriction affects dental and maxillary development. A low-protein diet only in gestation allows for normal development. A low-protein diet during gestation-lactation results in impaired odontogenesis.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lauriene Luiza S. Munhoz, Miria Tonus O. Alves, Beatriz C. Alves, Maria Gabriela F. S. Nascimento, Rafael M. Sabio, Karyn F. Manieri, Hernane S. Barud, Marcelo Augusto M. Esquisatto, Andrea A. Aro, Laura de Roch Casagrande, Paulo Cesar Lock Silveira, Glaucia Maria T. Santos, Thiago A. M. Andrade, Guilherme F. Caetano
Summary: This study evaluated the cell viability, minimum inhibitory concentration, and therapeutic effect of nanoscale silver compounds incorporated into bacterial cellulose membranes. The results showed that the silver nanoparticles had effective antimicrobial activity and promoted wound healing by balancing oxidative action and modulating the inflammatory response.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pathology
Cresle Andrei Zacarias, Rosimere Farias de Mendonca Florenziano, Thiago Antonio Moretti de Andrade, Andrea Aparecida de Aro, Maria Esmeria Corezola do Amaral, Glaucia Maria Tech dos Santos, Marcelo Augusto Marretto Esquisatto
Summary: The aim of this study was to test the effect of electrical stimulation in association with topical Arnica montana gel on dermal changes during tissue repair in rats. The results showed that the combination of microcurrent with ARN reduced the inflammatory process, increased myofibroblasts proliferation, and decreased the presence of macrophages in the dermis. The expression of vascular endothelial growth factor and matrix metalloproteinase-2 was also enhanced in the ARN + MC group.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Article
Surgery
Douglas Massoni Ramos, Raira de Brito Silva, Giancarlo de la Torre Canales, Luciana Resende, Marcelo Augusto Marretto Esquisatto, Nadia Cristina Favaro Moreira, Malin Ernberg, Celia Marisa Rizzatti-Barbosa
Summary: This study investigated the histomorphometric changes in the masseter muscle of rats after a single injection of botulinum toxin type A (BoNT-A). The results showed that the cross-sectional area of the masseter muscle was significantly lower in the BoNT-A group compared to the control group. Additionally, the BoNT-A group had increased myocyte quantity, decreased myocyte diameter, and increased connective tissue amount.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Chemistry, Applied
Eveleny Tirsa Vaca Meza, Jorge Vasquez-Kool, Noe Ildefonso Costilla Sanchez, Amandio Vieira, Rodney Alexandre Ferreira Rodrigues, Adilson Sartoratto, Angela del Pilar Flores Granados, Carmen Luisa Marin Tello, Ana Lucia Tasca Gois Ruiz
Summary: This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) from seven medicinal plants in Cachicadan, La Libertad Region, Peru. Gas chromatography-mass spectrometry analysis identified limonene and linalool as the common components in all EOs. The EO from Tagetes minuta leaves showed irreversible cytostatic effects against MCF-7 human breast tumor cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sergio Araujo, Marcela Fernanda Sganzella, Roberta Nicolli Sagiorato, Marcel Nani Leite, Guilherme Ferreira Caetano, Andrea Aparecida de Aro, Marcelo Augusto Marretto Esquisatto, Marco Andrey Cipriani Frade, Thiago Antonio Moretti de Andrade, Glaucia Maria Tech Santos
Summary: This study evaluated the immunomodulatory effect and wound healing process of xenografted human adipose-derived stem cells (ADSCs) in a fibrin glue matrix carrier in a full-thickness excisional model in rats. The results showed that ADSC+FG therapy stimulated the anti-inflammatory response, induced angiogenesis and collagen formation, and enhanced wound healing.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2022)
