Review
Optics
Bijie Bai, Xilin Yang, Yuzhu Li, Yijie Zhang, Nir Pillar, Aydogan Ozcan
Summary: Histological staining is an important technique in clinical pathology and research, but it is expensive, time-consuming, and limited in resource-limited settings. Deep learning techniques have provided a solution by digitally generating histological stains, which are rapid, cost-effective, and accurate alternatives to chemical staining methods. This review provides an overview of recent advances in deep learning-enabled virtual histological staining and discusses its future potential.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Swan N. Thung
Summary: Hepatocellular carcinoma is a primary liver cancer with molecular heterogeneity. Accurate diagnosis of HCC is crucial for patient management and prognosis. This review provides an update on HCC pathology.
Article
Agriculture, Dairy & Animal Science
Violaine Mechin, Patrick Pageat, Eva Teruel, Pietro Asproni
Summary: Chemical communication, specifically through the vomeronasal organ, plays a crucial role in animal behavior. This study demonstrates that aging significantly impacts the condition of the vomeronasal organ, leading to neuronal degeneration and changes in protein expression. The findings shed light on the effects of aging on chemical communication efficiency in animals.
Article
Immunology
M. R. Williams, C. M. Macdonald, F. E. Turkheimer
Summary: This study histologically examines the morphology of choroid plexus (CP) epithelial cells in patients with psychosis, schizophrenia and depression. It found increased somal width in the CP epithelial cells of schizophrenia patients without psychotic medication, indicating an illness-specific change mediated through the DA-system. No significant changes were observed in the CP epithelial cells of patients with major depressive disorder (MDD).
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Qing Cheng, Hang-Tong Hu, Hui Huang, Jia-Min Pan, Meng-Fei Xian, Yang Huang, Ming Kuang, Xiao-Yan Xie, Wei Li, Wei Wang, Ming-De Lu
Summary: Pathological factors such as fibrosis stage and histological grade can influence the contrast-enhanced ultrasonography (CEUS) Liver Imaging Reporting and Data System (LI-RADS) classification in patients at high risk of hepatocellular carcinoma. Hepatic fibrosis stage may affect arterial phase hyperenhancement (APHE) but does not impact the CEUS LI-RADS classification, while the histological grade of HCC can influence LR-5 and LR-TIV categories.
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Zarrilli, Valentina Angerilli, Gianluca Businello, Marta Sbaraglia, Giulia Traverso, Francesco Fortarezza, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Fiorella Calabrese, Angelo Paolo Dei Tos, Matteo Fassan
Summary: The histopathologic alterations in COVID-19 patients primarily occur in the lungs and blood vessels, with the highest clinical impact. However, many of the collected morphological data so far are nonspecific, erratic, and possibly associated with other co-existing factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Artificial Intelligence
Quoc Dang Vu, Kashif Rajpoot, Shan E. Ahmed Raza, Nasir Rajpoot
Summary: Diagnostic, prognostic and therapeutic decision-making of cancer in pathology clinics can now be carried out based on analysis of multi-gigapixel tissue images, also known as whole-slide images (WSIs). Deep convolutional neural networks (CNNs) have been proposed to derive unsupervised WSI representations, but a major trade-off is the lack of interpretability. To address this, a handcrafted framework called Handcrafted Histological Transformer (H2T) is presented, which offers competitive performance and is faster than Transformer models.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Oncology
Y. Wang, B. Acs, S. Robertson, B. Liu, L. Solorzano, C. Wahlby, J. Hartman, M. Rantalainen
Summary: The study developed a novel histological grade model (DeepGrade) based on digital whole-slide histopathology images and deep learning to improve risk stratification of NHG 2 breast cancer patients. DeepGrade provides independent prognostic information for stratification of NHG 2 cases and adds clinically relevant information over routine histological grading, serving as a cost-effective alternative to extract relevant information for clinical decisions.
ANNALS OF ONCOLOGY
(2022)
Editorial Material
Oncology
Paola Romeo, Damiano Arciuolo, Maria Cristina Moruzzi, Francesca Moro
Summary: The videos present two cases of serous epithelial ovarian carcinomas, showcasing the clinical, ultrasound, macroscopic, and histological features of a high grade serous ovarian carcinoma patient in the first video and a low grade serous ovarian carcinoma patient in the second video.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Biochemistry & Molecular Biology
Daniel Yoo, Valentin Goutaudier, Gillian Divard, Juliette Gueguen, Brad C. Astor, Olivier Aubert, Marc Raynaud, Zeynep Demir, Julien Hogan, Patricia Weng, Jodi Smith, Rouba Garro, Bradley A. Warady, Rima S. Zahr, Marta Sablik, Katherine Twombley, Lionel Couzi, Thierry Berney, Olivia Boyer, Jean-Paul Duong-Van-Huyen, Magali Giral, Alaa Alsadi, Pierre A. Gourraud, Emmanuel Morelon, Moglie Le Quintrec, Sophie Brouard, Christophe Legendre, Dany Anglicheau, Jean Villard, Weixiong Zhong, Nassim Kamar, Oriol Bestard, Arjang Djamali, Klemens Budde, Mark Haas, Carmen Lefaucheur, Marion Rabant, Alexandre Loupy
Summary: Researchers developed a decision-support system based on an algorithm to automatically assign kidney allograft diagnoses, which successfully reclassified rejection cases and improved long-term allograft outcomes.
Article
Microbiology
Corina Nave, Juliette Schwan, Sabine Werres, Janett Riebesehl
Summary: European alder dieback remains a serious issue, with the causal agent being the alder Phytophthora species complex. The aim of the research was to investigate the survival of these pathogens in alder roots, which revealed the presence of oogonia and oospores of P. xalni and P. uniformis.
Article
Pathology
Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda
Summary: This study reviewed clinicopathological and histopathological findings of 145 SFT cases and found that cellular or multinodular transformation may be associated with dedifferentiation. The authors also suggest that cellular and multinodular transformation may be associated with p16 overexpression and Rb downregulation.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Rheumatology
Debora Pehl, Corinna Preusse, Yves Allenbach, Olivier Benveniste, Philipp Dittert, Rieke Alten, Andreas Krause, Norman Goerl, Michael Zaenker, Hans-Hilmar Goebel, Udo Schneider, Werner Stenzel
Summary: The study provides insights into the pathological features of EF, showing inflammation at the muscle-fascia interface and involvement of CD206(+) macrophages and eosinophils. The immune phenotype of EF is similar to DM, but not associated with hypoxia-mediated processes. These findings offer new clues for further investigating the etiology and pathogenesis of EF.
Article
Gastroenterology & Hepatology
Yuexin Wang, Qi He, Danhua Yao, Yuhua Huang, Wenwen Xia, Weilin Chen, Zhe Cui, Yousheng Li
Summary: This study developed and validated a deep learning system to predict postoperative recurrence of Crohn's disease through automatic screening and identification of features of the muscular layer and myenteric plexus. The stacking model achieved satisfactory accuracy in predicting postoperative recurrence, and also showed good performance in identifying the severity of myenteric plexitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Oncology
Konstantin Brautigam, Antonio Rodriguez-Calero, Corina Kim-Fuchs, Attila Kollar, Roman Trepp, Ilaria Marinoni, Aurel Perren
Summary: The classification and nomenclature of neuroendocrine neoplasms (NEN) have undergone frequent changes recently, reflecting increasing knowledge and international standardization. The heterogeneity of NEN makes personalized therapy challenging, requiring more international collaborations and clinical trials for stratification according to biological subgroups.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Christine Laclef, Isabelle Anselme, Laurianne Besse, Martin Catala, Aurelien Palmyre, Dominique Baas, Marie Paschaki, Maria Pedraza, Christine Metin, Benedicte Durand, Sylvie Schneider-Maunoury
HUMAN MOLECULAR GENETICS
(2015)
Article
Neurosciences
Maria Figueres-Onate, Jorge Garcia-Marques, Maria Pedraza, Juan Andres De Carlos, Laura Lopez-Mascaraque
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Behavioral Sciences
Zoltan Molnar, Jon H. Kaas, Juan A. de Carlos, Robert F. Hevner, Ed Lein, Pavel Nemec
BRAIN BEHAVIOR AND EVOLUTION
(2014)
Review
Clinical Neurology
Christine Metin, Maria Pedraza
Article
Multidisciplinary Sciences
Maria Laura Ceci, Maria Pedraza, Juan A. de Carlos
Article
Multidisciplinary Sciences
Maria Pedraza, Anna Hoerder-Suabedissen, Maria Amparo Albert-Maestro, Zoltan Molnar, Juan A. De Carlos
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Anatomy & Morphology
Maria Pedraza, Juan A. De Carlos
FRONTIERS IN NEUROANATOMY
(2012)
Review
Anatomy & Morphology
Juan Lerma, Juan A. De Carlos
FRONTIERS IN NEUROANATOMY
(2014)
Article
Neurosciences
Itzel Escobedo-Avila, Fernanda Vargas-Romero, Anayansi Molina-Hernandez, Rodrigo Lopez-Gonzalez, Daniel Cortes, Juan A. De Carlos, Ivan Velasco
Article
Anatomy & Morphology
Juan A. De Carlos
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)