Article
Radiology, Nuclear Medicine & Medical Imaging
Scott K. Crawford, Darryl Thelen, Janice M. Yakey, Bryan C. Heiderscheit, John J. Wilson, Kenneth S. Lee
Summary: In patients with Achilles tendinopathy, traditional sonographic measures showed increased tendon thickness, hyperemia, and hypoechogenicity in the symptomatic tendon compared to the contralateral side. However, lower shear wave speed (SWS) was observed only in the free tendon, indicating localized alterations in tendon elasticity associated with Achilles tendinopathy.
EUROPEAN RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Subhajit Konar, Scott M. Bolam, Brendan Coleman, Nicola Dalbeth, Sue R. McGlashan, Sophia Leung, Jillian Cornish, Dorit Naot, David S. Musson
Summary: Tendinopathy is characterized by pathological changes in tendon matrix composition, architecture, and stiffness, with inflammation also playing an important role. This study found that substrate stiffness affects tendon-derived cells and macrophages. Tendon-derived cells showed minor responses to substrate stiffness, while macrophages exhibited a more inflammatory phenotype on non-physiological stiffness substrates. These subtle variations in matrix stiffness may contribute to the onset and progression of tendinopathy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Sport Sciences
Chia-Han Yeh, James D. Calder, Jarrod Antflick, Anthony M. J. Bull, Angela E. Kedgley
Summary: This study investigated the effects of eccentric loading exercises (ECC) and heavy slow resistance loading (HSR) on Achilles tendon force, finding that external load and maximum dorsiflexion angle are significant predictors of peak AT force. Standing position may be more effective for the same external load due to the rate at which peak dorsiflexion angle affects AT force being twice as high compared to seated position.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biochemistry & Molecular Biology
Danielle Steffen, Michael J. Mienaltowski, Keith Baar
Summary: The effect of mechanical load on tendinopathic tissue varies depending on the type of load. Dynamic loading increases fibrocartilage markers, while long isometric loads stimulate markers of tendon regeneration.
Article
Multidisciplinary Sciences
Pawel Szaro, Khaldun Ghali Gataa
Summary: This comparative study revealed that tendinopathy alters correlations between dimensions of the Achilles tendon, with significant differences in thickness and midportion width. Tendinopathy also showed positive correlations between certain dimensions that were negative in normal tendons, highlighting significant differences in dimensions correlations between healthy and tendinopathic tendons.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Zilu Ge, Wei Li, Renliang Zhao, Wei Xiong, Dong Wang, Yunfeng Tang, Qian Fang, Xiangtian Deng, Zhen Zhang, Yaojia Zhou, Xiaoting Chen, Yue Li, Yanrong Lu, Chengshi Wang, Guanglin Wang
Summary: Tendon stem/progenitor cells (TSPCs) therapy using a DNA hydrogel delivery system shows promising results in enhancing tendon injury repair. Encapsulating TSPCs in a DNA hydrogel creates an artificial extracellular matrix (ECM) microenvironment that provides nutrition and protection for the cells. TSPCs-Gel injections promote tendon healing and improve the mechanical properties of injured tendons. RNA-sequencing analysis also suggests potential gene and signaling pathway targets for further treatment strategies.
Review
Multidisciplinary Sciences
Wesley Matthews, Richard Ellis, James Furness, Wayne A. Hing
Summary: There is significant variation in the methodology and outcome measures used to diagnose Achilles tendinopathy. Subjective measures include self-reported location of pain and pain with tendon loading activities, while objective measures consist of tendon palpation and tendon pain during loading activities. The VISA-A questionnaire is commonly used as an outcome measure for monitoring Achilles tendinopathy.
Article
Cell Biology
Antonion Korcari, Samantha J. Przybelski, Anne Gingery, Alayna E. Loiselle
Summary: Aging leads to significant changes in tendon tissues, increasing the risk of tendinopathies and tendon injuries. However, there are inconsistencies in the understanding of tendon aging due to differences in age categories, anatomical locations, and animal models. This review summarizes the effects of aging on tendon mechanics, structure, composition, and the cellular environment, and proposes key directions for future research.
CONNECTIVE TISSUE RESEARCH
(2023)
Review
Medicine, General & Internal
Daniel Sullivan, Allison Pabich, Ryan Enslow, Avery Roe, Donald Borchert, Keenan Barr, Bailey Cook, Amanda Brooks
Summary: EOAT often presents with pain and swelling around the Achilles Tendon, is more common in men, and may demonstrate specific molecular signaling patterns. Although there is no standard treatment regimen, conservative management for six months is recommended for patients without complications. Further research is needed to determine the best course of clinical treatment for EOAT injuries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Rosa F. Monteiro, Syeda M. Bakht, Manuel Gomez-Florit, Fernanda C. Stievani, Ana L. G. Alves, Rui L. Reis, Manuela E. Gomes, Rui M. A. Domingues
Summary: The authors propose an automated 3D printing method to create tendon microphysiological systems (MPSs) embedded in a biomimetic fibrillar support platform. They use tendon decellularized extracellular matrix (dECM) to formulate bioinks that closely mimic the biochemical characteristics of tendon niche. They successfully recreate the cellular patterns and phenotype of the tendon core and study the interaction between different cell populations. The proposed concept shows promise for the automated fabrication of organotypic tendon-on-chip models, providing a valuable tool for studying tendon physiology, pathogenesis mechanisms, and testing new treatments for tendinopathies.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Runa Kinitz, Estelle Heyne, Lauren G. Koch, Steven L. Britton, Manuela Thierbach, Britt Wildemann
Summary: Old age, adiposity, and metabolic disorders are risk factors for chronic tendinopathy, and aging seems to play a prominent role in molecular and structural alterations of Achilles tendon tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Isabelle Scott, Peter Malliaras, Alex Tardioli, Sarah Hales, Dylan Morrissey, Filippo Migliorini, Nicola Maffulli
Summary: This study evaluated the immediate effect of running a marathon on Achilles tendon anteroposterior thickness. The results showed that running a marathon resulted in an immediate decrease in the anteroposterior diameter of the Achilles tendon, without changing the proportion of structural abnormalities or pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Rheumatology
N. Desai, J. F. Baker, J. Bucci, E. Y. Kissin
Summary: This systematic review aimed to evaluate the differences in ultrasound findings at the Achilles enthesis between inflammatory tendinopathy (IT) and non-inflammatory tendinopathy (NIT). The results showed that Achilles enthesis thickening was more frequent in the symptomatic IT group, while increased vascularity was more common in the NIT group. Erosions were also more common among the IT and sIT groups compared to the NIT and healthy controls.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Orthopedics
Xin Wang, Kui Xu, Eryang Zhang, Qian Bai, Baoan Ma, ChenGuang Zhao, Kailiang Zhang, Tao Liu, Zhouyong Ma, Hui Zeng, Yong Zhou, Zhao Li
Summary: IRE enhanced tendon tissue healing and blood supply, potentially reducing neuropathic pain, in a rat model of collagenase-induced Achilles tendinopathy.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
K. T. M. Opdam, R. Zwiers, J. I. Wiegerinck, C. N. van Dijk
Summary: The majority of orthopedic surgeons responded according to the latest proposals in the survey, and there has been an increasing trend of using terminology based on anatomic location, symptoms, clinical findings and histopathology from 2000 to 2016. The revised terminology is widely used in both daily practice and literature, but the use of Haglund eponyms remains common in Achilles tendon-related terminology.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Juliana A. R. Moreira, Israel C. Vasconcelos, Jose L. Fachi, Viviane Theodoro, Rodrigo A. Dalia, Andrea A. Aro, Edson R. Pimentel, Fernanda O. G. Gaspi, Thiago A. M. Andrade, Maria E. C. Amaral, Marcelo A. M. Esquisatto, Fernanda A. S. Mendonca, Glaucia M. T. Santos
Summary: The combination therapy of Solidago chilensis and laser reduced inflammatory infiltrate and promoted angiogenesis in burns of diabetic rats. Laser or plant extract alone showed higher levels of VEGF. Low-level laser therapy increased collagen I and decreased collagen III, as well as activated MMP-2 and reduced active MMP-9 isoform.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lais Rosa Viana, Leisa Lopes-Aguiar, Rafaela Rossi Rosolen, Rogerio Willians dos Santos, Maria Cristina Cintra Gomes-Marcondes
Article
Biochemistry & Molecular Biology
Fernanda O. Bortolazzo, Leticia D. Lucke, Lucas de Oliveira Fujii, Rita de Cassia Marqueti, Gracielle Vicira Ramos, Viviane Theodoro, Andre L. Bombeiro, Maira Felonato, Rodrigo A. Dalia, Giane D. Carneiro, Cristina Pontes Vicente, Marcelo A. M. Esquisatto, Fernanda A. S. Mendonca, Glaucia Maria T. dos Santos, Edson R. Pimentel, Andrea A. de Aro
Article
Cell Biology
Olivia Moraes Ruberti, Andressa Silva Sousa, Lais Rosa Viana, Moises Felipe Pereira Gomes, Alessandra Medeiros, Maria Cristina Cintra Gomes Marcondes, Luciano de Figueiredo Borges, Carlos Cesar Crestani, Cristiano Mostarda, Telma Fatima da Cunha Moraes, Rafael Renatino Canevarolo, Maria Andreia Delbin, Bruno Rodrigues
Summary: The study evaluated the impact of aerobic training on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes in ovariectomized rats with myocardial infarction. Aerobic training improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis revealed distinct metabolic profiles among different groups, with aerobic training group showing prevention of certain metabolic responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Cristiano Pedrozo Vieira, Leticia Prado de Oliveira, Mariana Bombardi Da Silva, Diana Majolli Andre, Edith Bastos Gandra Tavares, Edson Rosa Pimentel, Edson Antunes
Article
Oncology
Rebeka Tomasin, Aislan Cristina Rheder Fagundes Pascoal, Marcos Jose Salvador, Maria Cristina Cintra Gomes-Marcondes
Summary: Research has shown that treatment with a solution of Aloe vera and honey can reduce the metastatic propensity of tumors by modulating neoangiogenesis and the process of epithelial-to-mesenchymal transition. The analysis of the primary tumor tissues showed a decrease in N-cadherin expression and Cathepsin D activity in the treated groups, along with a decrease in blood vessel number and diameter. UHPLC-ESI-MS/MS analysis suggested the presence of molecules with verified antitumor activity in the Aloe vera and honey samples.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Nutrition & Dietetics
Natalia Angelo da Silva Miyaguti, Danijela Stanisic, Sarah Christine Pereira de Oliveira, Gabriela Sales dos Santos, Beatriz Schincariol Manhe, Ljubica Tasic, Maria Cristina Cintra Gomes-Marcondes
Article
Oncology
Bread Cruz, Andre Oliveira, Lais Rosa Viana, Leisa Lopes-Aguiar, Rafael Canevarolo, Maiara Caroline Colombera, Rafael Rossi Valentim, Fernanda Garcia-Fossa, Lizandra Maia de Sousa, Bianca Gazieri Castelucci, Silvio Roberto Consonni, Daniel Martins-de-Souza, Marcelo Bispo de Jesus, Steven Thomas Russell, Maria Cristina Cintra Gomes-Mardondes
Article
Food Science & Technology
Sarah Christine Pereira de Oliveira, Natalia Angelo da Silva Miyaguti, Steven Thomas Russell, Natalia Tobar, Murilo Vieira Geraldo, Maria Cristina Cintra Gomes-Marcondes
Summary: Maternal nutritional supplementation with fish oil during pre-mating, gestation, and lactation can positively impact muscle protein expression, liver function, and lipid metabolism in adult offspring, reducing cancer susceptibility and cachexia damages.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Anatomy & Morphology
Selma Delgado de Souza Moro, Lucas de Oliveira Fujii, Luis Felipe Rodrigues Teodoro, Katleen Frauz, Alysson Fernandes Mazoni, Marcelo Augusto Maretto Esquisatto, Rodney Alexandre Ferreira Rodrigues, Edson Rosa Pimentel, Andrea Aparecida de Aro
Summary: The study showed that topical application of Acmella oleracea ointment can increase collagen organization and content in injured tendons, potentially aiding in tendon repair. However, there were no significant differences observed in other aspects such as fibroblast numbers and blood vessel quantity between the ointment groups.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Review
Oncology
Melina de Moraes Santos Oliveira, Carla de Moraes Salgado, Lais Rosa Viana, Maria Cristina Cintra Gomes-Marcondes
Summary: This review highlights the importance of studying cancer during pregnancy and the role of leucine in improving placenta metabolism. It emphasizes the significance of researching the prognosis of mother and fetus in cases of cancer during pregnancy, as well as the similarities between trophoblastic and neoplastic cells and their implications for new research areas.
Article
Biochemistry & Molecular Biology
Gabriela de Matuoka e Chiocchetti, Leisa Lopes-Aguiar, Natalia Angelo da Silva Miyaguti, Lais Rosa Viana, Carla de Moraes Salgado, Ophelie Ocean Orvoen, Derly Florindo, Rogerio Williams dos Santos, Maria Cristina Cintra Gomes-Marcondes
Summary: Cancer cachexia is a severe wasting condition that requires further study to minimize damage and poor prognosis. Metabolic changes in skeletal muscle, especially increased amino acid levels and altered energetic metabolism, suggest an expressive catabolic process and diverted energy production, particularly in advanced tumor stages. Furthermore, the impact of cancer cachexia varies with host age, with more severe changes observed in weanling hosts throughout tumor evolution.
Article
Cell Biology
Lais Rosa Viana, Gabriela de Matuoka e Chiocchetti, Lucas Oroy, Willians Fernando Vieira, Estela Natacha Brandt Busanello, Ana Carolina Marques, Carla de Moraes Salgado, Alexandre Leite Rodrigues de Oliveira, Andre Schwambach Vieira, Paula Saenz Suarez, Lizandra Maia de Sousa, Bianca Gazieri Castelucci, Anibal Eugenio Vercesi, Silvio Roberto Consonni, Maria Cristina Cintra Gomes-Marcondes
Summary: A leucine-rich diet may prevent muscle atrophy in cancer cachexia patients, improve muscle strength and behavior performance, and decrease some protein degradation markers.
Article
Biochemistry & Molecular Biology
Natalia Angelo da Silva Miyaguti, Gabriela de Matuoka e Chiocchetti, Carla de Moraes Salgado, Leisa Lopes-Aguiar, Lais Rosa Viana, Lea Blanchard, Rogerio Willians dos Santos, Maria Cristina Cintra Gomes-Marcondes
Summary: This study found that Walker-256 tumor-induced cachexia impacts liver metabolism, with more severe effects in weanling hosts, characterized by increased levels of amino acids and impaired glucose metabolism. The study further revealed that liver alterations in tumor-bearing rats are related to energy status and nucleotide metabolites.
Article
Integrative & Complementary Medicine
Ivens Takechi Nakagawa, Hamilton Ricardo Alonso, Fabricio Campos Kuroda, Jose Roberto Passarini Junior, Juan Guzman Quispe Cabanillas, Fernanda Aparecida Sampaio Mendonca, Glaucia Maria Tech dos Santos, Andrea Aparecida de Aro, Edson Rosa Pimentel, Maria Esmeria Corezola do Amaral, Marcelo Augusto Marretto Esquisatto
Summary: This study demonstrated that electroacupuncture and laserpuncture can promote fibroblast proliferation, neoangiogenesis, and alter collagen fiber reorganization. The experimental groups showed different biological changes at different time points compared to the control group.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)