Article
Pediatrics
Mina Park, Gillian E. Hanley, Martin Guhn, Tim F. Oberlander
Summary: The study found that prenatal antidepressant exposure was associated with increased anxious behaviors and lower physical independence in children at kindergarten age, but had no significant effects on other developmental domains. These effects are likely attributable to the severity of underlying maternal mood disorders, emphasizing the importance of maternal mental health for developmental outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Marine & Freshwater Biology
W. Andrew Thompson, Zachary Shvartsburd, Mathilakath M. Vijayan
Summary: Early-life exposure to venlafaxine disrupts cardiac development in larval zebrafish, leading to increased heart rate, potentially due to enhanced serotonin stimulation of the 5-HT1A receptor.
AQUATIC TOXICOLOGY
(2022)
Article
Behavioral Sciences
Laura DeOliveira-Mello, Diego Baronio, Pertti Panula
Summary: Prenatal exposure to VPA in zebrafish leads to delay in visual system development and sleep disturbances, along with a reduction in certain cell populations associated with ASD.
Article
Computer Science, Artificial Intelligence
Noemi Mauro, Liliana Ardissono, Stefano Cocomazzi, Federica Cena
Summary: This study investigates the extraction of sensory data from consumer feedback and its integration into recommender systems to predict item ratings for people with autism spectrum disorders. The algorithms achieve highest accuracy and ranking capability using TripAdvisor data, and performance is further improved when both datasets are used.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
Nerea Llamosas, Sheldon D. Michaelson, Thomas Vaissiere, Camilo Rojas, Courtney A. Miller, Gavin Rumbaugh
Summary: The Syngap1 gene promotes experience-dependent excitatory synapse strengthening in the mouse cortex, while synaptic depression and bouton elimination are unaffected. It enhances somatic neural activity in weakly active neurons within cortical networks, but has little impact on highly active neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Jason L. He, Zachary J. Williams, Ashley Harris, Helen Powell, Roseann Schaaf, Teresa Tavassoli, Nicolaas A. J. Puts
Summary: Individuals on the autism spectrum process sensory information differently. However, inconsistent terminology describing sensory differences hampers understanding of their underlying causes. A hierarchical taxonomy is proposed to address this issue.
Article
Biochemistry & Molecular Biology
Hsiao-Ying Kuo, Fu-Chin Liu
Summary: This article discusses the role of monoamine neurotransmitter systems in the pathophysiology of autism spectrum disorder (ASD), with a focus on the effects of valproic acid (VPA) on the monoamine neurotransmitter systems. It also reviews the potential interactions between the microbiota and monoamine neurotransmitter systems in ASD pathophysiology.
Article
Cell Biology
Diego Baronio, Yu-Chia Chen, Pertti Panula
Summary: Deficiency of monoamine oxidase (MAO) and imbalanced levels of brain monoamines are associated with developmental delay, neuropsychiatric disorders, and aggressive behavior. This study introduces a novel genetic model using zebrafish to study the effects of mao loss of function. The results demonstrate alterations in neurotransmitter systems, expression of relevant genes, and behavioral changes in mao mutants.
DISEASE MODELS & MECHANISMS
(2022)
Article
Plant Sciences
Ran Li, Zhi-Mei Wang, Yan Wang, Xueqi Dong, Li-Hua Zhang, Tao Wang, Yan Zhu, Xiu-Mei Gao, Hong-Hua Wu, Yan-Tong Xu
Summary: This study systematically investigated the effects of SERT activity in antidepressant effects of Nardostachys jatamansi, including identification of active constituents and their potential mechanisms. The findings provide important insights into the antidepressant potential of this plant extract and fractions enriched with SERT enhancing compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
X. Tao, A. Newman-Tancredi, M. A. Varney, K. A. Razak
Summary: Fragile X Syndrome (FXS) is a genetic cause of Autism Spectrum Disorders (ASD) and intellectual disabilities. FXS is characterized by sensory hypersensitivity, especially in the auditory domain, which can lead to delayed language development and high anxiety. In a mouse model of FXS, the Fmr1 KO mouse, auditory hypersensitivity and audiogenic seizures are observed. The activation of serotonin-1A receptor (5-HT1A) can reduce audiogenic seizures in Fmr1 KO mice.
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Natalie Hesselgrave, Timothy A. Troppoli, Andreas B. Wulff, Anthony B. Cole, Scott M. Thompson
Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Leon Jesus German-Ponciano, Gilberto Uriel Rosas-Sanchez, Jonathan Cueto-Escobedo, Rafael Fernandez-Demeneghi, Gabriel Guillen-Ruiz, Cesar Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: Depressive disorders are a highly disabling global disease, with increasing incidence in recent decades. Flavonoids hold promise as potential antidepressants, with mechanisms that are not fully understood. Individuals with depression have low levels of serotonin and BDNF, which can be reversed by flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Duan Liu, Yongxian Zhuang, Lingxin Zhang, Huanyao Gao, Drew Neavin, Tania Carrillo-Roa, Yani Wang, Jia Yu, Sisi Qin, Daniel C. Kim, Erica Liu, Thanh Thanh Le Nguyen, Joanna M. Biernacka, Rima Kaddurah-Daouk, Boadie W. Dunlop, W. Edward Craighead, Helen S. Mayberg, Elisabeth B. Binder, Mark A. Frye, Liewei Wang, Richard M. Weinshilboum
Summary: ERICH3 gene may play a significant role in vesicular function in serotonergic and other neuronal cell types, which could help explain its association with plasma serotonin concentrations and SSRI clinical response.
MOLECULAR PSYCHIATRY
(2021)