Article
Biochemistry & Molecular Biology
Hui Li, Xiaoyu Fan, Xiangmeng Wu, Weiguo Han, Mary Kay Amistadi, Pengfei Liu, Donna Zhang, Jon Chorover, Xinxin Ding, Qing-Yu Zhang
Summary: This study found that exposure to arsenic through drinking water significantly induced high levels of HO-1 in mouse intestinal epithelial cells, but not in the liver. Intestinal epithelial cells were identified as potential preferential targets for arsenic toxicity, highlighting the importance of further research on the functional consequences of intestinal HO-1 induction.
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Plant Sciences
Jing Ni, Yuanmin Li, Yawei Xu, Rong Guo
Summary: Salidroside has been found to significantly improve diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis by up-regulating HO-1 expression through activation of the AKT signaling pathway. This demonstrates the cardio-protective effect of salidroside in diabetic mice, which is dependent on AKT signaling activation.
Article
Cell Biology
Jiawen Yang, Jiajie Mo, Juji Dai, Chenqiao Ye, Wei Cen, Xuzhi Zheng, Lei Jiang, Lechi Ye
Summary: This study demonstrates that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells by regulating the p38/Nrf2/HO-1 axis to promote ferroptosis. These findings suggest a potential strategy to overcome drug resistance in KRAS mutant colorectal cancer.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sarah E. Machado, Daryll Spangler, Delores A. Stacks, Victor Darley-Usmar, Gloria A. Benavides, Min Xie, Jozsef Balla, Abolfazl Zarjou
Summary: Given the important role of heme proteins in mitochondrial function, this study investigated the significance of myocardial ferritin heavy chain (FtH) in acute myocardial infarction. The results showed that FtH deletion did not impact mitochondrial regulation, bioenergetics, or cardiac function. Furthermore, FtH deletion led to the upregulation of anti-ferroptotic genes, including HO-1 and Slc7a11, suggesting a compensatory mechanism. The induction of HO-1 resulted in increased expression of Slc7a11, ultimately protecting the heart against ischemia-reperfusion-mediated ferroptosis and preserving myocardial and mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Krzeptowski, Patryk Chudy, Grzegorz Sokolowski, Monika Zukowska, Anna Kusienicka, Agnieszka Seretny, Agata Kalita, Alicja Czmoczek, Jakub Gubala, Sonia Baran, Damian Kloska, Mateusz Jez, Jacek Stepniewski, Krzysztof Szade, Agata Szade, Anna Grochot-Przeczek, Alicja Jozkowicz, Witold N. Nowak
Summary: G-quadruplexes are nucleic acid structures stabilized by heme, influencing DNA replication and gene transcription. The accumulation of G-quadruplexes is affected by heme oxygenase-1 expression in a cell-type-specific manner. Cellular co-localization of G-quadruplexes with helicases and HMOX1 can be detected using the proximity ligation assay, providing insights into potential roles of HMOX1 in G4 modifications.
Article
Biochemistry & Molecular Biology
Olga Mucha, Katarzyna Kazirod, Paulina Podkalicka, Kinga Rusin, Jozef Dulak, Agnieszka Loboda
Summary: This study investigates the role of heme oxygenase-1 (HO-1) in the regulation of autophagy and mitophagy in a mouse model of Duchenne muscular dystrophy (DMD). It is found that HO-1 may alleviate the symptoms of DMD through its anti-inflammatory properties. The study also reveals complex and age-dependent dysregulation of autophagic and mitophagic markers in DMD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Oncology
Jonathan L. Hecht, Monika Janikova, Reeham Choudhury, Fong Liu, Giacomo Canesin, Lubica Janovicova, Eva Csizmadia, Elisa M. Jorgensen, Katharine M. Esselen, Peter Celec, Kenneth D. Swanson, Barbara Wegiel
Summary: This study investigates the link between endometriosis and ovarian clear cell cancer (OCCC) and proposes that altered heme metabolism and the presence of oxidative stress in the immune niche may drive OCCC development. The study also highlights the role of macrophages in this process and identifies elevated levels of HO-1 as a potential biomarker for inflammation.
