Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 292, Issue 4, Pages 557-561Publisher
WILEY
DOI: 10.1002/ar.20872
Keywords
Hensen's node; node; asymmetry; time-lapse imaging; cellular motion; tissue motion; Fgf8; Shh
Categories
Funding
- American Heart Association Postdoctoral Fellowship [0620105Z]
- National Institutes of Health
- INBRE Program
- NCRR [P20 RR016475]
- G. Harold and Leila Y Mathers Charitable Foundation
- [NIHLB R01]
- [068855]
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Current hypotheses regarding vertebrate left-right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time-lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline. Anat Rec, 292:557-561, 2009. (C) 2009 Wiley-Liss, Inc.
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