Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 11, Pages 27956-27966Publisher
MDPI
DOI: 10.3390/ijms161126063
Keywords
IL-33; ubiquitin-specific protease 17 (USP17); IL-13; DNA binding; deubiquitinase
Funding
- National Basic Research Program of China (973 Program) [2014CB541803, 2014CB541903]
- NSFC [81270083, 81330072, 31370863, 31170825, 31200646, 31200647, 81271835, 81302532, 81270714, 31300711, 31350110505]
- Chinese Academy of Sciences [2013Y1SB0005]
Ask authors/readers for more resources
IL-33 is a new member of the IL-1 family cytokines, which is expressed by different types of immune cells and non-immune cells. IL-33 is constitutively expressed in the nucleus, where it can act as a transcriptional regulator. So far, no direct target for nuclear IL-33 has been identified, and the regulation of IL-33 nuclear function remains largely unclear. Here, we report that the transcription of type 2 inflammatory cytokine IL-13 is positively regulated by nuclear IL-33. IL-33 can directly bind to the conserved non-coding sequence (CNS) before the translation initiation site in the IL13 gene locus. Moreover, IL-33 nuclear function and stability are regulated by the enzyme ubiquitin-specific protease 17 (USP17) through deubiquitination of IL-33 both at the K48 and at the K63 sites. Our data suggest that IL13 gene transcription can be directly activated by nuclear IL-33, which is negatively regulated by the deubiquitinase USP17.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available