Review
Nutrition & Dietetics
Karina Piatek, Martin Schepelmann, Enikoe Kallay
Summary: Ovarian cancer is a deadly cancer in women, but the current treatments have debilitating side effects. Therefore, there is a need for new treatments with fewer side effects. Vitamin D has anticancer effects, but high doses cause hypercalcemia. Researchers are looking for analogs of vitamin D to reduce side effects.
Review
Nutrition & Dietetics
Michal A. Zmijewski
Summary: Vitamin D exhibits a variety of activities, including both classic pathway- and vitamin D receptor-dependent transcriptional modulation, as well as rapid and nongenomic responses. It has cell-protective effects, triggers calcium influx, modulates intracellular processes, and influences mitochondrial function. The mechanisms of these nongenomic responses are still not fully understood, but their impact on physiology, pathology, and potential clinical applications are discussed in this review.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martyna Fronczek, Joanna Katarzyna Strzelczyk, Krzysztof Biernacki, Silvia Salatino, Tadeusz Osadnik, Zofia Ostrowska
Summary: The study investigated the role of genetic variation in the CYP2R1 gene in vitamin D deficiency among healthy Polish individuals. Two substitutions were found in selected gene fragments, with one potentially influencing the structure and function of CYP2R1. Further functional verification is needed to confirm these findings.
Review
Food Science & Technology
Vaibhav Kumar Maurya, Amita Shakya, Khalid Bashir, Kulsum Jan, David Julian McClements
Summary: This article discusses the challenges and potential solutions for fortifying foods with vitamin D, which has low solubility, stability, and bioavailability. Encapsulating vitamin D within well-designed delivery systems containing nanoscale or microscale particles could overcome these challenges. The concept of fortification by design is introduced, involving a systematic approach to select appropriate vitamin D form, food matrix, delivery system, production method, testing procedures, and system optimization.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Teresa Zolek, Kaori Yasuda, Geoffrey Brown, Toshiyuki Sakaki, Andrzej Kutner
Summary: By studying the 3D structure of the vitamin D-metabolizing enzyme CYP3A4, we can predict and explain its metabolic conversion of analogs of 1,25D2. This is highly important for the design of stable vitamin D-based drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ye Li, Katherine L. Cook, Wei Yu, Lu Jin, Kerrie B. Bouker, Robert Clarke, Leena Hilakivi-Clarke
Summary: Elevated expression of VDR in pretreatment tumors of ER+ breast cancer patients treated with TAM is associated with longer recurrence-free survival. Differentially expressed pathways such as autophagy and unfolded protein response (UPR) were identified between high and low VDR-expressing ER+ cancers.
Review
Immunology
Xiaowu Liu, Ziqian Yao, Yanchun Wang, Luyu Chai, Xu Zhou
Summary: This systematic review found that the combination of vitamin D analogs and phototherapy (NBUVB) is more effective than phototherapy alone for treating vitiligo, with tacalcitol showing greater efficacy than calcipotriol. However, the evidence does not support the use of vitamin D analogs in combination with PUVA or EL for vitiligo treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Esmeralda Magro-Lopez, Irene Chamorro-Herrero, Alberto Zambrano
Summary: Contrary to expectations, the biologically active form of vitamin D did not have therapeutic effects in bleomycin-induced lung fibrosis but instead aggravated lung pathology. The current study focused on evaluating the effects of two hypocalcemic vitamin D analogs on DNA damage expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Glenville Jones
Summary: This article provides a unique perspective on the discovery of vitamin D and its deficiency disease, rickets, covering four distinct historical phases and highlighting major developments in the field.
ENDOCRINE CONNECTIONS
(2022)
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Pharmacology & Pharmacy
Samaneh Siapoush, Hanieh Mousazadeh, Ramazan Rezaei, Behzad Hatami, Sogol Mazhari, Naimeh Hashemi, Mohammad Reza Zali, Kaveh Baghaei
Summary: Researchers have developed pH-sensitive polymer-based nanoparticles for targeted delivery of Imatinib in the treatment of liver fibrosis. The use of Vitamin A-modified Imatinib-loaded nanoparticles showed efficient drug release in the intestine and preferential accumulation in the liver. This targeted nanoparticle delivery significantly reduced liver damage and fibrosis marker gene expression.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Samuel Seoane, Pranjal Gogoi, Araceli Zarate-Ruiz, Carole Peluso-Iltis, Stefan Peters, Thierry Guiberteau, Miguel A. Maestro, Roman Perez-Fernandez, Natacha Rochel, Antonio Mourino
Summary: This article reports the development of two highly active and noncalcemic analogues of 1,25D3 that lack the C-ring and possess an m-phenylene ring that replaces the natural D-ring. The new compounds are noncalcemic and show transcriptional and antiproliferative activities similar to 1,25D3. Structural analysis revealed that they induce a large conformational rearrangement of the vitamin D receptor around helix 6.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Piotr Lacina, Aleksandra Butrym, Eliza Turlej, Martyna Stachowicz-Suhs, Joanna Wietrzyk, Grzegorz Mazur, Katarzyna Bogunia-Kubik
Summary: This study confirms the importance of BSG/MCT1 in AML, and suggests that soluble BSG and BSG/MCT1 genetic variants may act as potential AML biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Justyna Joanna Gleba, Dagmara Klopotowska, Joanna Banach, Eliza Turlej, Karolina Anna Mielko, Katarzyna Gebura, Katarzyna Bogunia-Kubik, Andrzej Kutner, Joanna Wietrzyk
Summary: This study aimed to determine the use of active forms of vitamin D-3, calcitriol and tacalcitol, as anticancer drugs for leukemias and lymphomas, and to identify the molecular factors responsible for cell sensitivity to these agents. The results suggest that VDR gene receptor polymorphism may be associated with the response to these drugs in cancer therapy.
Article
Biochemistry & Molecular Biology
Justyna Joanna Gleba, Dagmara Klopotowska, Joanna Banach, Karolina Anna Mielko, Eliza Turlej, Magdalena Maciejewska, Andrzej Kutner, Joanna Wietrzyk
Summary: Non-coding micro-RNAs (miRNAs) regulate cell growth and proliferation and play a role in the response of cancer cells to drug treatment. This study investigated the correlation between selected miRNAs and regulated proteins in leukemia and lymphoma cells in response to two active forms of vitamin D-3. The results showed a correlation between the levels of certain miRNAs (most notably miR-27b and miR-125b) and the levels of proteins involved in cell regulation, suggesting their potential role in the anticancer activity of vitamin D-3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Patrycja Koszalka, Barbara Kutryb-Zajac, Paulina Mierzejewska, Marta Tomczyk, Joanna Wietrzyk, Pawel K. Serafin, Ryszard T. Smolenski, Ewa M. Slominska
Summary: This study found that the metabolic product 4PYR, which accumulates in the blood of cancer patients, promotes lung metastasis through multiple mechanisms. In vivo studies showed that 4PYR did not affect primary tumor growth but facilitated lung metastasis. In vitro studies demonstrated that 4PYR affected extracellular adenine nucleotide metabolism and intracellular energy status, leading to increased permeability of lung ECs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Dratwa, Barbara Wysoczanska, Wioletta Brankiewicz, Martyna Stachowicz-Suhs, Joanna Wietrzyk, Rafal Matkowski, Marcin Ekiert, Jolanta Szelachowska, Adam Maciejczyk, Mariusz Szajewski, Maciej Baginski, Katarzyna Bogunia-Kubik
Summary: This study investigated the molecular mechanisms of TERT upregulation in breast cancer, including genetic variability and telomere length, as well as the expression of TERT, MYC, TP53, and SP1 genes in BC patients and BC organoids. Results showed correlations between TERT genotypes, TP53 expression, and telomere length, suggesting TERT genetic variability may serve as potential biomarkers for breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Marta Switalska, Beata Filip-Psurska, Magdalena Milczarek, Mateusz Psurski, Adrianna Moszynska, Aleksandra M. Dabrowska, Malgorzata Gawronska, Karol Krzyminski, Maciej Baginski, Rafal Bartoszewski, Joanna Wietrzyk
Summary: The combined treatment of C-1305 and PTX showed anticancer activity and improved tumor blood perfusion in in vivo studies. It resulted in increased level of CCL2 and decreased level of PDGF. Furthermore, the treatment modulated the levels of certain angiogenesis-related cytokines.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Oncology
Beata Filip-Psurska, Honorata Zachary, Aleksandra Strzykalska, Joanna Wietrzyk
Summary: This article reviews the impact of vitamin D-3 on Th17 cells in breast cancer, finding that its effectiveness depends on factors such as age, menopausal status, and obesity. Moreover, the role of vitamin D-3 in breast cancer development is controversial. Due to the scarcity of scientific data on Th17 lymphocytes and breast cancer, further clinical trials and studies are needed to assess the importance of vitamin D in breast cancer.
Article
Biochemistry & Molecular Biology
Vaikunthavasan Thiruchenthooran, Marta Switalska, Lorena Bonilla, Marta Espina, Maria Luisa Garcia, Joanna Wietrzyk, Elena Sanchez-Lopez, Anna Gliszczynska
Summary: The aim of this study was to design innovative nanostructured lipid carriers (NLCs) to deliver dexibuprofen (DXI) as an antiproliferative therapy against tumoral processes and overcome its side effects. Through optimization of the formulation, DXI-NLCs with small particle size, high entrapment efficiency, and slow drug release were obtained. The DXI-NLCs showed the highest activity against breast cancer cells, providing early preclinical evidence for the treatment of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Agnieszka Krakos (Podwin), Joanna Jarosz, Patrycja Sniadek, Mateusz Psurski, Adrianna Graja, Marcin Bialas, Ewa Oliszewska, Joanna Wietrzyk, Rafal Walczak, Jan Dziuban
Summary: This paper presents a lab-on-chip platform for the long-term cultivation of human cancer cells, which meets the requirements of CubeSat biological missions. Cancer cell lines UM-UC-3 and RT 112 were cultured on the chip for up to 50 days, showing successful results and providing a basis for further testing in terrestrial and space conditions.
Article
Biochemistry & Molecular Biology
Alicja Skrzypek, Monika Karpinska, Malgorzata Juszczak, Aneta Grabarska, Joanna Wietrzyk, Elzbieta Krajewska-Kulak, Marek Studzinski, Tadeusz Paszko, Joanna Matysiak
Summary: Benzoxazole and naphthoxazole fused systems, functionalized by the 2,4-dihydroxyphenyl moiety, showed potential activity in inhibiting AChE, anticancer effects, and antioxidant properties. Naphtho[1,2-d][1,3]oxazoles exhibited higher antiproliferative activity against human cancer cell lines compared to benzoxazoles, with one analog showing no toxicity to normal cells.
Article
Biochemistry & Molecular Biology
Henryk Mastalarz, Agnieszka Mastalarz, Joanna Wietrzyk, Magdalena Milczarek, Andrzej Kochel, Andrzej Regiec
Summary: Two new platinum(II) complexes (1 and 2) were synthesized and characterized using various analytical techniques. The cytotoxicity of these complexes against different cancer cell lines was evaluated, and their cellular platinum uptake and stability were determined. Complex 2 showed higher cytotoxic activity compared to cisplatin, while complex 1 exhibited varying activity against different cancer cell lines.
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Eliana B. Souto, Marta Espina, Maria Luisa Garcia, Marta Switalska, Joanna Wietrzyk, Anna Gliszczynska, Elena Sanchez-Lopez
Summary: Cancer is a leading cause of death worldwide, but there is still a need for an effective treatment with minimal adverse effects. Diclofenac, a non-steroidal anti-inflammatory drug, has shown promise as an antitumoral agent, but its prolonged use can lead to adverse effects. In this study, biodegradable polymeric nanoparticles were used to deliver diclofenac in a controlled manner, resulting in prolonged release and demonstrating antitumoral effects without cytotoxicity to non-tumoral cells.
Article
Biochemistry & Molecular Biology
Tomasz Tronina, Agnieszka Bartmanska, Jaroslaw Poplonski, Magdalena Rychlicka, Sandra Sordon, Beata Filip-Psurska, Magdalena Milczarek, Joanna Wietrzyk, Ewa Huszcza
Summary: The antiproliferative activity of xanthohumol and its aurone derivative was investigated against ten human cancer cell lines and two normal cell lines. Both flavonoids showed potent to moderate anticancer activity against most tested cancer cell lines, including drug-resistant ones, while the reference drug cisplatin acted non-selectively. The findings suggest that these flavonoids have strong potential as candidates for further studies in the search for effective anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Milczarek, Tomasz Cierpial, Piotr Kielbasinski, Milena Malecka-Gieldowska, Marta Switalska, Joanna Wietrzyk, Maciej Mazur, Katarzyna Wiktorska
Summary: The combination of 5-fluorouracil and ISC has synergistic effects on triple-negative breast cancer, leading to enhanced antiproliferative effects and safety.
