Article
Chemistry, Multidisciplinary
Mohamed Choukairi, Dounia Bouchta, Loubna Bounab, Elisa Gonzalez-Romero, Mohamed Achache, Khalid Draoui, Faiza Chaouket, Ihssane Raissouni, Mouad Gharous
Summary: A novel modification of a paste carbon electrode using Bentonite and l-Cysteine was developed for the detection and quantification of uric acid and ascorbic acid. The electrode surface was characterized using electrochemical impedance spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopic analysis. The sensor exhibited good stability, sensitivity, selectivity, and regeneration ability, with a limit of detection of 0.031 μm for uric acid and 9.6 μm for ascorbic acid. The sensor showed good linearity in the concentration range of 0.1-100 μm for uric acid and 10-1000 μm for ascorbic acid. The peak-to-peak separation of uric acid and ascorbic acid was determined to be 330 mV. The sensor was successfully applied for the monitoring of uric acid and ascorbic acid in serum samples.
Article
Chemistry, Applied
P. A. Pushpanjali, J. G. Manjunatha, N. Hareesha, T. Girish, Abdullah A. Al-Kahtani, Ammar Mohamed Tighezza, Narges Ataollahi
Summary: Selective, sensitive, easy, and fast voltammetric techniques were developed for the analysis of Hydroxychloroquine (HCQ). The analysis was carried out using a modified carbon nanotube paste electrode and a phosphate buffer solution. The detection of HCQ showed a linear response in a certain concentration range and a proposed mechanism for HCQ oxidation was proposed.
TOPICS IN CATALYSIS
(2022)
Article
Materials Science, Multidisciplinary
Ebrahim Naghian, Zahra Mahmoodi, Faezeh Shahdost-fard, Fatemeh Nosratzehi, Kourosh Adib, Mohammad Aghaei, Hadi Mohamedian, Mehdi Rahimi-Nasrabadi
Summary: The use of manganese ferrite nanoparticles as a modifier in an electrochemical sensor significantly improved the detection of dopamine and uric acid in biofluids, showing promise for simultaneous monitoring and selective measurement. The sensor demonstrated reliability in the presence of common interferences and feasibility in detecting the analytes in complex samples such as human urine and blood serum. These findings suggest the potential of MnFe2O4 NPs as a beneficial platform in electrocatalysis fields.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Electrochemistry
Sonia Sam, Manna Rachel Mathew, K. Girish Kumar
Summary: This article presents the development of a simple electropolymer-based voltammetric sensor for the sensitive determination of melanoma biomarkers, L-Dopa, and L-Tyrosine. The modified glassy carbon electrode exhibits excellent electro-catalytic properties for the oxidation of the analytes, enabling their simultaneous determination. The sensor shows consistent performance in terms of fabrication, characterization, calibration, and real sample applicability, and the spike recovery analysis confirms its practical application in real sample analysis.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Emad A. Khudaish, Adhara Al-Badri
Summary: Functionalized carbon nanotubes with excess oxygen-containing functional groups were prepared using a modified Hummers method, showing exceptional electrochemical activity for norepinephrine detection in serum blood samples with a low detection limit. The sensor exhibited good selectivity and recovery rates.
Article
Electrochemistry
Arya S. Madhavan, Lineesh M. Kunjappan, Leena Rajith
Summary: A novel nanocomposite of reduced graphene oxide (RGO) and spinel Cu0.5Co0.5Fe2O4 was synthesized and used to fabricate a sensor capable of simultaneously detecting L-dopa and melatonin. Electrochemical characterization and application studies showed that PBS buffer at pH 7 was the optimal experimental medium for further research.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Fotini Vasiliou, Alexios K. Plessas, Anastasios Economou, Nicolaos Thomaidis, Giannis S. Papaefstathiou, Christos Kokkinos
Summary: In this work, a new type of graphite paste electrode modified with a water-stable Cu(II)-complex was used for the voltammetric determination of glucose and uric acid in sweat. The electrode showed favorable electrochemical performance and low limits of detection for both biomarkers, without interference from common electroactive metabolites.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Rui An, Wenzhu Kuang, Zijian Li, Tiancheng Mu, Hongxia Luo
Summary: In this study, carbon nano-onions (CNOs) with particle sizes of 5-10 nm were successfully synthesized using the multi-potential step method. The effective synthesis of CNOs was confirmed by high-resolution transmission electron microscopy, infrared spectroscopy, and Raman spectroscopy. CNOs/GCEs were prepared by depositing the CNOs onto glassy carbon electrodes (GCEs) using a drop-coating method. The electrocatalytic activity of the CNOs/GCE sensor was examined by simultaneously detecting dopamine (DA), uric acid (UA), L-tryptophan (Trp), and theophylline (TP) using differential pulse voltammetry. The sensor showed wide linear ranges and low detection limits for all four analytes, as well as good stability and capability for real sample detection.
Article
Chemistry, Multidisciplinary
Edwige Mouafo-Tchinda, Justin Claude Kemmegne-Mbouguen, Charles Peguy Nanseu-Njiki, Henrietta W. Langmi, Chrispin Kowenje, Nicholas M. Musyoka, Robert Mokaya
Summary: An organoclay/Cu-MOF composite was synthesized using a solvothermal method and drop coating was used to form a stable thin film onto glassy carbon electrodes. These electrodes demonstrated electrocatalytic behavior toward DXEP, AC, and TYR, enabling their selective and simultaneous sensitive detection compared to bare electrodes and clay modified electrodes.
Article
Chemistry, Multidisciplinary
Tingting Ma, Yue Wang, Yasushi Hasebe, Zhiqiang Zhang
Summary: A simple, rapid, cost-effective and non-enzymatic amperometric sensor based on CB-MLN modified GCE was developed for sensitive and simultaneous determination of UA, DA, and AA. The synergistic effect of CB and MLN enhanced the electrochemical catalytic reaction and oxidation currents of UA, DA, and AA. The sensor demonstrated excellent performance in the electrochemical oxidation of AA, DA, and UA with well-separated oxidation potentials and low detection limits.
Article
Chemistry, Analytical
Nasrin Soltani, Nahid Tavakkoli, Razieh Malakoti, Fatemeh Davar, Maryam Khayatkashani, Hossein Salavati
Summary: In this study, a sensor based on an electrochemical process was developed for the analysis of the anti-estrogen drug tamoxifen in water. The modified electrode showed enhanced sensitivity and selectivity for tamoxifen measurement. This sensor has potential applications in drug analysis and detection.
MICROCHEMICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Seung Hyeon Ko, Seung Wook Kim, Yi Jae Lee
Summary: The sensor demonstrated selective low level detection of dopamine through the use of graphene oxide/PEDOT:PSS composite, which provided well-tailored interfacial properties for highly sensitive and selective determination of dopamine.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Multidisciplinary
M. M. Charithra, J. G. Manjunatha
Summary: A novel voltammetric sensor for detecting Adrenaline was developed and tested in this study, showing enhanced sensing ability compared to traditional methods. The sensor demonstrated high selectivity, reproducibility, and an excellent antifouling property, making it a promising candidate for electrochemical sensing applications.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Electrical & Electronic
Sadik Cogal, Venkat R. Bhethanabotla
Summary: In this study, a nanocomposite of two-dimensional WSe2 nanosheets with carbon black was prepared and used for electrode modification for the simultaneous electrochemical detection of AA, DA, and UA. The modified electrode exhibited enhanced electrocatalytic properties, wide linear ranges, and low detection limits for the target analytes. Additionally, it demonstrated high reproducibility and stability.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Shining Wu, Haoran Wang, Bo Zhao, Tongtong Cao, Juanjuan Ma, Lin Liu, Zhiwei Tong
Summary: A highly sensitive nanocomposite electrochemical sensor for simultaneous detection of dopamine, ascorbic acid, and uric acid was successfully synthesized and characterized in terms of structure and electrochemical properties. The experimental results demonstrate that the sensor has good stability and anti-interference performance, with detection limits for dopamine, ascorbic acid, and uric acid within specific concentration ranges.
Article
Biochemistry & Molecular Biology
Zahra Aramesh-Boroujeni, Nahal Aramesh, Shohreh Jahani, Mozhgan Khorasani-Motlagh, Kagan Kerman, Meissam Noroozifar
Summary: The study showed that these lanthanide complexes interact with BSA through a static process, primarily via van der Waals force. Additionally, they exhibited promising antimicrobial activity and significant cytotoxicity against tumor cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Energy & Fuels
Marzieh Cheraghipoor, Davod Mohebbi-Kalhori, Meissam Noroozifar, Malek Taher Maghsoodlou
Summary: In this study, ceramic membranes with different compositions were fabricated and used as separators in microbial fuel cells (MFCs). The addition of SiO2 to the membrane had varying effects on MFCs performance, with significant improvements observed when 30% SiO2 was added to non-leached soil.
Article
Biochemistry & Molecular Biology
ShaoPei Li, Aruna Raja, Meissam Noroozifar, Kagan Kerman
Summary: Parkinson's disease (PD) is associated with the aggregation and misfolding of α-synuclein (α-syn) protein. A proof-of-concept study found that pyrroloquinoline quinone (PQQ) can effectively prevent ROS formation and fibrillation of α-syn-119 in the presence of Cu(II), suggesting PQQ as a potential multitarget therapeutic agent for PD.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Hamid Fini, Qusai Hassan, Meissam Noroozifar, Kagan Kerman
Summary: A novel hybrid bilayer membrane is introduced as a platform for studying the aggregation of amyloid-beta peptide on surfaces. The modified electrodes were characterized using XPS and ToF-SIMS, and electrochemical methods were used to investigate the interaction of the modified surfaces with the amyloid-beta peptide. The results showed a decrease in charge transfer resistance upon incubation of the peptide, indicating the potential of this platform for studying membrane-bound receptors.
Article
Nanoscience & Nanotechnology
Celia Ferrag, Meissam Noroozifar, Kagan Kerman
Summary: In this study, an ultralight graphene oxide aerogel decorated with bimetallic palladium-iron nanoparticles was synthesized and immobilized on a glassy carbon electrode for electrochemical sensor applications. The sensor was able to simultaneously detect eight biomolecules and exhibited excellent performance, stability, reproducibility, and sensitivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Maryam Abdinejad, Siddhartha Subramanian, Mozhgan Khorasani Motlagh, Meissam Noroozifar, Salatan Duangdangchote, Ihor Neporozhnii, Davide Ripepi, Donato Pinto, Mengran Li, Keith Tang, Joost Middelkoop, Atsushi Urakawa, Oleksandr Voznyy, Heinz-Bernhard Kraatz, Thomas Burdyny
Summary: In this study, a bimetallic Cu-Pd composition on 2D Ti3C2Tx (MXene) nanosheets is formulated to achieve more efficient formate production in CO2RR. By using a membrane electrode assembly (MEA), formate selectivities >90% and the highest reported overall energy efficiency of 47% are achieved at a current density of 150 mA cm(-2). This simple strategy represents an important step towards the experimental demonstration of 3D-MXenes-based electrocatalysts for CO2RR application and opens up a new platform for the fabrication of macroscale aerogel MXene-based electrocatalysts.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qusai Hassan, Chevon Riley, Meissam Noroozifar, Kagan Kerman
Summary: In this study, a novel hybrid nanomaterial-based electrochemical sensor was developed for the simultaneous detection of four DNA bases. Graphene oxide quantum dots (GOQDs) were synthesized and used to prepare a hybrid nanomaterial with multi-walled carbon nanotubes (GOQD-MWCNT). The modified sensor showed linear calibration plots up to a concentration of 50, 50, 500, and 500 μM for guanine, adenine, thymine, and cytosine, respectively. The sensor was also successfully applied for the determination of DNA bases in artificial saliva samples, with recovery values ranging from 95.9% to 106.8%.
Article
Chemistry, Analytical
Qusai Hassan, Zhixin Meng, Meissam Noroozifar, Kagan Kerman
Summary: Sugarcane biochar and methylene blue were used to develop a graphite paste electrode (GPE-SC-MB) for the simultaneous detection of four DNA bases. The linear ranges and detection limits were as follows: G: 0.67-38.67 μM and 0.037 μM, A: 0.67-126.67 μM and 0.042 μM, and T/C: 6.67-1600 μM and 4.25 μM, 5.33 μM. The GPE-SC-MB showed recovery values between 99.0 and 103.0% when tested in human saliva, indicating the effectiveness of sugarcane biochar as an electrode modifier for sensitive electrochemical sensors.
Article
Chemistry, Analytical
Niloufar Soltani, Qusai Hassan, Meissam Noroozifar, Kagan Kerman
Summary: In this proof-of-concept study, gold nanoparticles (AuNPs) were immobilized on a surface-modified glassy carbon electrode (GCE-Ph-S-AuNPs) using a surface-anchored diazonium salt of 4-aminothiophenol. The attachment of AuNPs onto the modified electrode surface was confirmed by X-ray photoelectron spectroscopy. Differential pulse voltammetry was performed to simultaneously determine guanine (G) and 8-hydroxyguanine (8-OH-G), with linear calibration curves up to 140 μM and 60 μM, and detection limits of 0.02 μM and 0.021 μM for G and 8-OH-G, respectively. Chronoamperometric studies were also conducted to determine the diffusion coefficients of 8-OH-G and G. The GCE-Ph-S-AuNPs were successfully applied to determine G and 8-OH-G in genomic DNA-spiked samples with recovery rates between 98.5% and 103.3%. This novel electrochemical surface provides a potential platform for the sensitive detection of 8-OH-G related to oxidative stress-induced DNA damage in clinical studies.
Article
Chemistry, Analytical
Niloufar Soltani, Meissam Noroozifar, Kagan Kerman
Summary: In this proof-of-concept study, a graphite paste electrode modified with a hybrid nanocomposite of multi-walled carbon nanotubes and iron-oxide nanoparticles was developed for the simultaneous voltammetric detection of guanine and inosine. The modified electrode showed enhanced electrocatalytic activity and good detection performance in commercially available bovine serum samples. This nanocomposite-modified sensor holds promise for the detection of guanine and inosine in pharmaceutical formulations and biological samples, serving as biomarkers of oxidative damage related to cancer research.
Article
Chemistry, Physical
Sona Niroomand, Abbas Jahanara, Shohre Jahani, Ghasem Sargazi, Brian O. Patrick, Meissam Noroozifar, Mozhgan Khorasani-Motlagh
Summary: UV-Vis and IR spectroscopy, elemental analysis, and X-ray crystallography were used to characterize a novel dimeric Lanthanum(III) complex with 1,10-phenanthroline (phen). The compound exhibited antibacterial, anticancer, and DNA and protein binding properties. Molecular modeling and absorption and fluorescence spectroscopy methods were used to study the binding qualities and thermodynamic parameters. The complex showed good antibacterial action, significant cytotoxicity, and high affinity for DNA and protein binding.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yilei Xue, Qusai Hassan, Meissam Noroozifar, Ruby May A. Sullan, Kagan Kerman
Summary: In this proof-of-concept study, a microfluidic flow injection analysis system using multiwalled carbon nanotube-modified screen-printed carbon electrodes modified with copper nanoparticles was developed for the sensitive detection of dopamine. The system showed high sensitivity and reproducibility, and has the potential to be used as an electrochemical point-of-care device for rapid dopamine detection.
Article
Chemistry, Physical
Zehao Fang, Junyan Wang, Yilei Xue, Mozhgan Khorasani Motlagh, Meissam Noroozifar, Heinz-Bernhard Kraatz
Summary: In this study, a bimetallic palladium-copper aerogel was synthesized and used for modification of a graphite paste electrode, enabling the sensitive determination of bisphenol A. The properties of the modified electrode were characterized using various techniques, and it was found to exhibit good selectivity, stability, and sensitivity for BPA determination.
