Article
Agriculture, Dairy & Animal Science
Yinchuan Pan, Xu Liu, Jing Liu, Jianping Wang, Juxiang Liu, Yanxia Gao, Ning Ma
Summary: In this study, a chemiluminescence sensor was developed using a molecularly imprinted polymer (MIP) for specific detection of organophosphorus residues in milk samples. The sensor showed high sensitivity and reusability, and can be used as a routine tool for detecting OP residues.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biophysics
Patrycja Lach, Alvaro Garcia-Cruz, Francesco Canfarotta, Alistair Groves, Jakub Kalecki, Dominik Korol, Pawel Borowicz, Kostiantyn Nikiforow, Maciej Cieplak, Wlodzimierz Kutner, Sergey A. Piletsky, Piyush Sindhu Sharma
Summary: Redox-active MIP-Gly NPs were developed by incorporating ferrocenylmethyl methacrylate into the synthesis process, enabling them to selectively determine glyphosate without the need for redox probe. MIP-Gly NPs synthesized using allylamine and squaramide-based monomers exhibited the highest selectivity. The MIP-Gly NPs modified Pt-SPEs were characterized using differential pulse voltammetry and electrochemical impedance spectroscopy, with changes in the oxidation peak of the ferrocenyl moieties serving as the analytical signal. The chemosensor showed a low limit of detection and a wide linear dynamic concentration range for glyphosate, allowing successful detection in spiked river water samples.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Analytical
Xianzhi Huang, Ling Xia, Gongke Li
Summary: Molecularly imprinted polymers (MIPs) have been widely used in sensing due to their specific and high affinity for target molecules. MIP optical sensors, combining the preconcentration capability of MIPs and the quantification merit of optical techniques, have been applied to analyze various samples and gained considerable attention. This review provides an overview of the progress of MIP sensors combined with optical detection methods, including fluorescence, surface plasmon resonance, Raman scattering, and chemiluminescence. The construction, characterization, working principle, and application of four types of MIP optical sensors are discussed in detail. Finally, the opportunities and challenges faced by MIP optical sensors are summarized.
Review
Chemistry, Analytical
Viknasvarri Ayerdurai, Maciej Cieplak, Wlodzimierz Kutner
Summary: Food safety assessment plays a crucial role in the modern food industry, driven by increased public awareness and the rise in food pollutants due to globalization, industrialization, and population growth. Electrochemical sensors with molecularly imprinted polymer (MIP) recognition units have become a popular choice for food analysis. These sensors offer simplicity in preparation and measurement, cost-efficiency, and a high affinity for target contaminants. The review highlights recent developments in MIP-based electrochemical sensors and their applications in detecting contaminants in various food and drink samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This work presents a molecularly imprinted (MIP) sensor for the determination of ethanethiol. The MIP/GCE sensor showed a linear range of 6.1-32.4 mg L-1 with good detection capability and reproducibility. The sensitivity of the sensor was enhanced by incorporating gold nano-particles. The sensor was successfully applied to determine ethanethiol in spiked wine samples.
Article
Chemistry, Analytical
Zahra Mirzaei Karazan, Mahmoud Roushani
Summary: This study introduces an easy detection method for Hippuric Acid (HA) using electrochemical polymerization technique. The sensor exhibited good sensitivity and a wide linear range for HA detection, and it was successfully applied to determine HA in real samples.
Article
Spectroscopy
Ali Mokhtari, Mozhdeh Barati, Hossein Karimian, Mohsen Keyvanfard
Summary: In this study, a molecularly imprinted polymerized high internal phase emulsion (MIP-polyHIPE) adsorbent was used for selective preconcentration of the anti-plaque drug clopidogrel. Chemiluminescence (CL) methods were evaluated for the determination of clopidogrel, with the Ru(phen)(3)(2+)-Cerium (IV) CL system showing reasonable sensitivity. The proposed method demonstrated good sensitivity and accuracy for the determination of clopidogrel in pharmaceuticals and blood serum samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Viknasvarri Ayerdurai, Maciej Cieplak, Krzysztof R. Noworyta, Marianna Gajda, Agnieszka Ziminska, Marta Sosnowska, Joanna Piechowska, Pawel Borowicz, Wojciech Lisowski, Shuai Shao, Francis D'Souza, Wlodzimierz Kutner
Summary: The electrochemical sensor with MIP film was developed for selective determination of tyramine, with a detection limit of 159 and 168 μM. The sensor showed a linear dynamic range from 290 μM to 2.64 mM, high selectivity, and an apparent imprinting factor of 5.6.
BIOELECTROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Greta Pilvenyte, Vilma Ratautaite, Raimonda Boguzaite, Arunas Ramanavicius, Roman Viter, Simonas Ramanavicius
Summary: Biomarkers are crucial in providing information about cancer and other diseases. Molecularly imprinted polymers (MIPs) have recently been used in analytical systems to detect cancer biomarkers, such as prostate cancer (PSA), breast cancer (CA15-3, HER-2), ovarian cancer (CA-125), hepatocellular carcinoma (AFP), and small molecule cancer biomarkers (5-HIAA and neopterin). The determination of low concentrations of these biomarkers in complex matrices is challenging, but MIP-based biosensors have been employed for assessment. This article provides an overview of the MIP-based sensor creation principles, analytical signal determination methods, and suitable materials for each biomarker through comparing and discussing the results of reviewed biosensors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yan Huang, Daixin Ye, Jing Yang, Wenyi Zhu, Li Li, Yaping Ding
Summary: A novel molecularly imprinted electrochemical aptasensor (MIEAS) using SnO2-Gr nanomaterial and AuNPs was developed for selective progesterone (P4) detection. The MIEAS exhibited improved selectivity due to the synergetic effect of the molecularly imprinted polymer (MIP) and aptamer towards P4. The sensor had a low detection limit of 1.73 x 10-15 M and showed satisfactory recovery in tap water and milk samples, indicating its potential in environmental and food analysis.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Xinning Dong, Congcong Zhang, Xin Du, Zhenguo Zhang
Summary: Molecularly imprinted polymer (MIP) is a synthetic material that mimics the natural antibody-antigen system and is suitable for use in electrochemical sensors. However, the irregular shape and slow electron transfer rate of MIP limit the sensitivity and conductivity of the sensors. The integration of nanomaterials improves the sensing and recognition capability of MIP sensors.
Article
Biophysics
Whitchuta Jesadabundit, Sakda Jampasa, Kanitha Patarakul, Weena Siangproh, Orawon Chailapakul
Summary: This study reported a novel enzyme-free impedimetric biosensor for the selective and sensitive determination of the biomarker L-hydroxyproline for early diagnosis of bone diseases. By using a mixture of monomers for coelectropolymerization, the biosensor showed high selectivity and sensitivity, and successfully detected L-hydroxyproline in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yan Huang, Xuyuan Sun, Jing Yang, Zhiyuan Cao, Rujie Wang, Li Li, Yaping Ding
Summary: A molecularly imprinted electrochemical sensor with dual functional monomers was designed for selective determination of gatifloxacin (GTX). The sensor exhibited higher specificity towards GTX with a wide linear range and low detection limit. Satisfactory recovery in real water samples confirmed the potential of this method in antibiotic contaminant determination.
Article
Chemistry, Analytical
Ece Ozkan, Goksu Ozcelikay, Elif Damla Gok Topak, Emirhan Nemutlu, Sibel A. Ozkan, Omer Dizdar, Sercan Aksoy, Sedef Kir
Summary: In this study, a molecularly imprinted polymer film (P (ANI)@MIP) was fabricated on the electrode surface using aniline as a functional monomer and octreotide as a template molecule. The P (ANI)@MIP film layer was evaluated and optimized to obtain the best electrochemical sensor for octreotide analysis. The developed P (ANI)@MIP/GCE sensor exhibited high sensitivity and selectivity for octreotide and was used to determine its concentration in cancer patient plasma samples.
Article
Chemistry, Analytical
Shanshan Li, Tingting Zhong, Qingxia Long, Cuiping Huang, Liying Chen, Dujuan Lu, Xin Li, Zhiqing Zhang, Guanghui Shen, Xiaoyan Hou
Summary: An electrochemical sensor utilizing molecularly imprinted polymer (MIP) on gold nanoparticles (AuNPs) electrode was developed for histamine (HIS) determination, showing enhanced performance and successful detection in alcoholic beverages. The results were in good agreement with high-performance liquid chromatography (HPLC) method, indicating the reliability and applicability of the proposed methodology for HIS detection in beer and wine samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Gang Qu, Yuxin Zhao, Qiaoli Zhang, Jina Wu, Xiaosen Li, Yang Yang, Shilei Liu
Summary: In this study, magnetic mesoporous materials combined with real-time in situ mass spectrometry were used for the high-throughput detection of hydrolyzed products of organophosphorus nerve agents. The method showed good linearity, low limits of detection and quantification, and high extraction recoveries. The magnetic preparation method used was quick, cost-effective, rugged, and safe. The results demonstrated the potential of this method for rapid and efficient determination of the target analytes in environmental samples.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Anna Hildebrand, Mariam Merchant, Danny O'Hare
Summary: Substandard and falsified artemisinin derivatives in antimalarials have caused significant deaths and economic losses. This study evaluates the feasibility of voltammetric methods for identifying and quantifying artemether. The findings suggest that electrochemical analysis shows promise as a method for artemether identification and quantification.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Marx Osorio Araujo Pereira, Alvaro Ferreira Junior, Edson Silvio Batista Rodrigues, Helena Mulser, Giovanna Nascimento de Mello e Silva, Wallans Torres Pio dos Santos, Eric de Souza Gil
Summary: Brazilian spotted fever (BSF) is a serious and rapidly evolving disease. A new impedimetric immunosensor was developed for rapid diagnosis by measuring specific antibodies in plasma. The sensor demonstrated selectivity and accuracy, and has potential for important applications in diagnostic testing.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Kathrin Schilling, Ronald A. Glabonjat, Olgica Balac, Marta Galvez-Fernandez, Arce Domingo-Relloso, Vesna Slavkovich, Jeff Goldsmith, Miranda R. Jones, Tiffany R. Sanchez, Ana Navas-Acien
Summary: Analysis of trace elements in urine is an important tool for assessing exposures, diagnosing nutritional status, and guiding public health and healthcare intervention. This study provides a sensitive method for analyzing 18 elements in urine samples, using only 100 μL. The results show good accuracy and sensitivity of the method.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Mengya Li, Shijie Liu, Shiliang Guo, Dong Liang, Miaoyun Li, Yaodi Zhu, Lijun Zhao, Jong-Hoon Lee, Gaiming Zhao, Yangyang Ma, Yanxia Liu
Summary: In this study, a magnetic flow device was developed to purify spores in a culture medium system. The device used magnetic nanoparticles to absorb vegetative cells, separating them from the spores. The achieved purity of the collected spores was over 95%. The study also demonstrated a rapid quantitative detection method using Raman spectroscopy.
ANALYTICAL METHODS
(2024)
Article
Chemistry, Analytical
Wanqiong Liu, Zixuan Wu, Jianwei Peng, Zebin Xu, Yong Liang
Summary: Metal-organic frameworks (MOFs) are effective carriers for molecular imprinting, but their poor dispersibility in aqueous solution is a significant drawback. In this study, we have applied amphiphilic block copolymers and molecularly imprinted technology on MOFs to improve the hydrophilicity of molecularly imprinted fluorescent materials.
ANALYTICAL METHODS
(2024)