Journal
ANALYTICAL METHODS
Volume 6, Issue 3, Pages 878-885Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ay41762j
Keywords
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Funding
- National Natural Science Foundation of China [51175268, 11102090]
- Specialized Research Fund for the Doctoral Program of Ministry of Education [20113219110004]
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Paper microfluidic devices are a promising technology in developing analytical devices for point-of-care diagnosis in the developing world. This article describes a simple method for paper microfluidic devices based on a PZT drop-on-demand droplet generator. Wax was jetted in the form of droplet, linked with each other and formed into wax pattern on filter paper with a PZT actuator and a glass nozzle. The heated wax pattern became a hydrophobic barrier for reagent used in bio-assay. The glass nozzle fabricated by a home-made micronozzle puller without complicated fabrication technology was low cost, simple and easily made. Coefficient of variation of the jetted wax droplet diameter was 4.0% which showed good reproducibility. The width of wax line was experimentally studied by changing the driving voltage, nozzle diameters and degree of overlapping. The wax line with width of 700-1700 mm was prepared for paper based microfluidic devices. Multi-assay of glucose, protein and pH and 3 x 3 arrays of glucose, protein and pH assay were realized with the prepared paper microfluidic devices. The wax droplet generating system supplied a low-cost, simple, easy-to-use and fast fabrication method for paper microfluidic devices.
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