Journal
ANALYTICAL METHODS
Volume 5, Issue 23, Pages 6686-6692Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ay41149d
Keywords
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Funding
- National Science Foundation [0847205-CHE]
- National Science Foundation Instrumentation Development for Biological Research [DBI 0852740]
- National Center for Research Resources [5R21RR031246-03]
- National Institute of General Medical Sciences [8 R21 GM103454]
- National Institutes of Health
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0847205] Funding Source: National Science Foundation
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Direct mass spectrometry analysis of untreated samples of volumes as low as 0.2 mu L was achieved using fast extraction and nanoESI (electrospray ionization) in a combined fashion. The analytes in dried samples on paper substrates were extracted by an organic solvent in a nanoESI tube and ionized with a high voltage applied for generating a spray. The ionization source produced stable signals for different atmospheric pressure interfaces of triple quadrupole instruments. Analysis times more than 20 minutes were available with 10 mu L solvent consumed for the entire analysis process. The performance in qualitative and quantitative analyses was characterized with a wide variety of samples. Limits of detection as low as 0.1 ng mL(-1) (corresponding to an absolute amount of 0.05 pg) were obtained for analysis of atrazine in river water, thiabendazole in orange homogenate, and methamphetamine in blood.
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