The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation

The role of T cell receptor signaling thresholds in guiding T cell fate decisions

(2015) Julie Zikherman et al.   CURRENT OPINION IN IMMUNOLOGY

RNA-binding protein hnRNPLL regulates mRNA splicing and stability during B-cell to plasma-cell differentiation

(2015) Xing Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

(2014) P. Bielli et al.   EMBO REPORTS

Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response

(2014) Kyung Soo Park et al.   JOURNAL OF IMMUNOLOGY

Zfp318 Regulates IgD Expression by Abrogating Transcription Termination within theIghm/IghdLocus

(2014) Peter D. Pioli et al.   JOURNAL OF IMMUNOLOGY

Identification of cis-Acting Elements and Splicing Factors Involved in the Regulation of BIM Pre-mRNA Splicing

(2014) Wen Chun Juan et al.   PLoS One

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

(2014) A. Enders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA

(2014) Vicky Cho et al.   GENOME BIOLOGY

Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS

(2013) Hirokazu Hara et al.   FEBS Journal

Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn

(2013) Nicole M. Martinez et al.   IMMUNOLOGICAL REVIEWS

Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells

(2012) M.-C. Gaudreau et al.   JOURNAL OF IMMUNOLOGY

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing

(2012) Manish J. Butte et al.   PLoS One

Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells

(2012) M. J. Benson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse

(2012) Y. L. Khodor et al.   RNA

The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing

(2012) Erica A. Moehle et al.   PLoS Genetics

RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic Outcomes

(2011) Steve D. Wilton et al.   CURRENT GENE THERAPY

Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila

(2011) Y. L. Khodor et al.   GENES & DEVELOPMENT

Signal- and Development-Dependent Alternative Splicing of LEF1 in T Cells Is Controlled by CELF2

(2011) M. J. Mallory et al.   MOLECULAR AND CELLULAR BIOLOGY

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Differential Requirement for the CD45 Splicing Regulator hnRNPLL for Accumulation of NKT and Conventional T Cells

(2011) Mehmet Yabas et al.   PLoS One

Alternative Splicing Factor/Splicing Factor 2 Regulates the Expression of the ζ Subunit of the Human T Cell Receptor-associated CD3 Complex

(2010) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation

(2010) Z. Wu et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

(2010) Florian Heyd et al.   MOLECULAR CELL

Context-Dependent Regulatory Mechanism of the Splicing Factor hnRNP L

(2010) Laura B. Motta-Mena et al.   MOLECULAR CELL

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

An emerging role for nuclear RNA-mediated responses to genotoxic stress

(2010) Roberta Busà et al.   RNA Biology

Involvement of tyrosine phosphatase CD45 in apoptosis

(2009) Geneviève Dupéré-Minier et al.   APOPTOSIS

Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

(2009) Melissa J. Moore et al.   CELL

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

(2009) Kathleen Martincic et al.   NATURE IMMUNOLOGY

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Expression analysis and functional activity of interleukin-7 splice variants

(2008) N K Vudattu et al.   GENES AND IMMUNITY

Alternative Splicing of CD45: The Tip of the Iceberg

(2008) Julie Zikherman et al.   IMMUNITY

Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL

(2008) Zuopeng Wu et al.   IMMUNITY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Innate immunity to pathogens: diversity in receptors for microbial recognition

(2008) Shizuo Akira   IMMUNOLOGICAL REVIEWS

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

CD127 immunophenotyping suggests altered CD4+ T cell regulation in primary progressive multiple sclerosis

(2008) Fiona C. McKay et al.   JOURNAL OF AUTOIMMUNITY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4

(2008) J. D. Topp et al.   RNA

Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL

(2008) S. Oberdoerffer et al.   SCIENCE