Journal
ANALYTICAL METHODS
Volume 4, Issue 11, Pages 3531-3535Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ay25663k
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Funding
- National Key Program for Basic Research of China [2011CB910603]
- National High-Tech Research and Development Program [2012AA020203]
- International Scientific Cooperation Project of China [2011DFB30370]
- National Natural Science Foundation of China [20905077, 30900258]
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Here we developed a facile method using the polycyclic aromatic hydrocarbon ethidium bromide (EB) for glycan derivatization, to enhance the ionization efficiency and detection sensitivity of glycans in mass spectrometry (MS). The cationic nature of EB also notably improved identification of neutral and acidic glycans of real samples, as well as their structural analysis.
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