Journal
ANALYTICAL METHODS
Volume 3, Issue 8, Pages 1769-1773Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ay05130j
Keywords
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Funding
- Natural Science Foundation of China [20805004, 20725517, 20821120292]
- Fundamental Research Funds for the Central Universities [N090405004, N090105001]
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A cross-linked chitosan/multi-wall carbon nanotube (MWCNTs) nanocomposite is prepared via surface deposition-cross linking. The nanocomposite is characterized by means of FT-IR, SEM and TGA analysis, indicating that a chitosan layer is well coated on the surfaces of the MWCNTs, weighing about 35% of the total mass. Investigations on the performance of the chitosan/MWCNTs nanocomposite to the adsorption or loading of hemoglobin indicated that the adsorption equilibrium time is reduced from a few hours in the conventional protocols to 25 min in the present case. A theoretical adsorption capacity of 15.41 mu g mg(-1) is achieved, corresponding to a 6-fold improvement when compared to that obtained by using conventional chitosan particles in the micrometre range at a same mass condition. The nanocomposite is used as an adsorbent for the isolation of hemoglobin from human whole blood, the SDS-PAGE results indicated that successful separation of hemoglobin is obtained in the presence of large amount of abundant protein, e.g., human serum albumin.
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