Review
Immunology
Rocio Gallego-Duran, Rocio Montero-Vallejo, Douglas Maya-Miles, Ana Lucena, Franz Martin, Javier Ampuero, Manuel Romero-Gomez
Summary: MAFLD is the most prevalent form of liver disease globally, with immune responses playing a key role in its development, leading to various injuries and loss of function in the liver due to metabolic and immune changes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
James B. Maurice, Robert Goldin, Andrew Hall, Jennifer C. Price, Giada Sebastiani, Caryn G. Morse, Laura Iogna Prat, Hugo Perazzo, Lucy Garvey, Patrick Ingiliz, Giovanni Guaraldi, Emmanouil Tsochatzis, Maud Lemoine
Summary: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver disease in people living with human immunodeficiency virus (PLWH). This study found a strong association between body mass index and NAFLD, as well as between type 2 diabetes and advanced fibrosis in PLWH. Additionally, further optimization of serological markers for fibrosis is needed.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Guido A. Baselli, Oveis Jamialahmadi, Serena Pelusi, Ester Ciociola, Francesco Malvestiti, Marco Saracino, Luigi Santoro, Alessandro Cherubini, Paola Dongiovanni, Marco Maggioni, Cristiana Bianco, Federica Tavaglione, Annalisa Cespiati, Rosellina M. Mancina, Roberta D'Ambrosio, Valentina Vaira, Salvatore Petta, Luca Miele, Umberto Vespasiani-Gentilucci, Alessandro Federico, Jussi Pihlajamaki, Elisabetta Bugianesi, Anna L. Fracanzani, Helen L. Reeves, Giorgio Soardo, Daniele Prati, Stefano Romeo, Luca VC. Valenti
Summary: This study investigated the impact of rare variants on severe non-alcoholic fatty liver disease, and found that loss-of-function variants in the ATG7 gene promote the progression of NAFLD.
JOURNAL OF HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Monika Bischoff, Sebastian Zimny, Sebastian Feiner, Johannes Sauter, Svenja Sydor, Gerald Denk, Jutta M. Nagel, Gert Bischoff, Christian Rust, Simon Hohenester
Summary: This study found that lifestyle intervention in morbidly obese patients can significantly improve serum ALT levels and surrogate markers of NAFLD, indicating its importance in treating NAFLD and advanced fibrosis.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Leke Wiering, Pallavi Subramanian, Linda Hammerich
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a wide range of severity, from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, making hepatic fibrosis an important predictor of outcomes. Recent advancements in understanding the activation and inactivation of hepatic stellate cells, which drive fibrosis development, have shed light on the disease progression in NAFLD/NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Pediatrics
Antonella Mosca, Luca Della Volpe, Anna Alisi, Silvio Veraldi, Paola Francalanci, Giuseppe Maggiore
Summary: The study showed that Hepamet and APRI perform better than NFS and FIB-4 in identifying fibrosis in NAFLD patients. However, their positive predictive values are not high enough to be considered diagnostic, indicating the need for further research on new markers for fibrosis.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Benjamin Riviere, Audrey Jaussent, Valerie Macioce, Stephanie Faure, Nicolas Builles, Patrick Lefebvre, Philippe Geraud, Marie-Christine Picot, Sandra Rebuffat, Eric Renard, Valerie Paradis, Marie-Dominique Servais, Nathalie de Preville, David Nocca, Anne-Dominique Lajoix, Georges-Philippe Pageaux, Florence Galtier
Summary: The study suggests that the triglycerides and glucose (TyG) index is associated with the diagnosis of nonalcoholic steatohepatitis (NASH) and can be used as a noninvasive tool to predict the need for liver biopsy.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Nisreen Nimer, Ibrahim Choucair, Zeneng Wang, Ina Nemet, Lin Li, Janet Gukasyan, Taylor L. Weeks, Naim Alkhouri, Nizar Zein, W. H. Wilson Tang, Michael A. Fischbach, J. Mark Brown, Hooman Allayee, Srinivasan Dasarathy, Valentin Gogonea, Stanley L. Hazen
Summary: Metabolomic studies have shown that plasma levels of bile acids are elevated in subjects with NAFLD compared to healthy controls. Specific bile acids are associated with the transition from simple hepatic steatosis to NASH, as well as genetic determinants. This suggests a potential role for bile acid metabolism in the development and progression of NASH.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Surgery
Saleh A. Alqahtani, Pegah Golabi, James M. Paik, Brian Lam, Amir H. Moazez, Hazem A. Elariny, Zachary Goodman, Zobair M. Younossi
Summary: In a study of morbidly obese patients, NFS, FIB-4, and APRI were found to be ineffective at detecting advanced fibrosis but were valuable for excluding it. At optimal thresholds, the tests had good NPV but low PPV, and combining them did not improve performance. Additional research is needed to develop new NITs with high positive predictive value.
Letter
Gastroenterology & Hepatology
Amandeep Singh, Rajat Garg, Rocio Lopez, Naim Alkhouri
Summary: This study aims to develop a simple noninvasive fibrosis score to detect advanced fibrosis in patients with diabetes and compare its performance with other fibrosis scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Alessandra Pandolfo, Ciro Celsa, Michela Antonucci, Carlo Ciccioli, Giuseppe Infantino, Claudia La Mantia, Stefanie Parisi, Adele Tulone, Vito Di Marco, Antonio Craxi, Calogero Camma, Salvatore Petta
Summary: This study aimed to assess the accuracy of AGILE 3+, a score based on various factors, for the diagnosis of advanced fibrosis and the prediction of liver-related events in patients with NAFLD. The results showed that AGILE 3+ had higher diagnostic performance compared to FIB-4 and LSM.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Camille Houron, Dragos Ciocan, Nicolas Trainel, Francoise Mercier-Nome, Cindy Hugot, Madeleine Spatz, Gabriel Perlemuter, Anne-Marie Cassard
Summary: The study suggests that pectin plays a positive role in non-alcoholic fatty liver disease (NAFLD) by affecting gut bacteria, with preventive and curative fecal microbiota transfer (FMT) having different mechanisms of action on NAFLD.
Review
Medicine, General & Internal
Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan L. Dumitrascu
Summary: After analyzing the role of visfatin in nonalcoholic fatty liver disease, it was found that visfatin levels are not associated with NAFLD, presence or severity of hepatic steatosis, liver fibrosis, lobar inflammation, NASH, and gender.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
James A. Thomas, Bradley J. Kendall, Christine Dalais, Graeme A. Macdonald, Aaron P. Thrift
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with hepatocellular carcinoma (HCC) and extrahepatic cancer. The incidence rate of HCC is higher in patients with advanced liver fibrosis or cirrhosis, while the incidence rate of extrahepatic cancers is even higher. These findings emphasize the importance of prevention and early detection of cancer in adults with NAFLD.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Stefania Grimaudo, Paola Dongiovanni, Jussi Pihlajamaki, Mohammed Eslam, Hannele Yki-Jarvinen, Rosaria Maria Pipitone, Guido Baselli, Calogero Camma, Vito Di Marco, Marco Enea, Miriam Longo, Grazia Pennisi, Daniele Prati, Rossella Zito, Anna Ludovica Fracanzani, Antonio Craxi, Jacob George, Stefano Romeo, Luca Valenti, Salvatore Petta
Summary: The NR1H4 gene rs35724 C allele is protective against severity of steatosis, steatohepatitis, and liver fibrosis, but is associated with higher total circulating cholesterol levels. Patients carrying the NR1H4 rs35724 C allele show increased hepatic mRNA levels of FXR and genes involved in bile acid synthesis. This suggests that increased hepatic FXR expression due to the NR1H4 rs35724 C allele may have potential therapeutic implications for NAFLD.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Vicente Sperb Antonello, Ivan Carlos Ferreira Antonello, Sandra Herrmann, Cristiane Valle Tovo
Article
Parasitology
Camila V. Pereira, Cristiane Valle Tovo, Thiago K. Grossmann, Henrique Mirenda, Bruna B. Dal-Pupo, Paulo R. L. de Almeida, Angelo A. de Mattos
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2016)
Article
Nutrition & Dietetics
Giselle Souza Pinto, Anelise Femanda Zanolla, Cristiane Valle Tovo, Catarina Bertaso Andreatta Gottschall, Caroline Buss
NUTRICION HOSPITALARIA
(2016)
Article
Infectious Diseases
Kelly Fernanda Nomura Dresch, Angelo Alves de Mattos, Cristiane Valle Tovo, Fernanda Quadros de Onofrio, Leandro Casagrande, Alberi Adolfo Feltrin, Iago Christofoli de Barros, Paulo Roberto Lerias de Almeida
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2016)
Article
Gastroenterology & Hepatology
Dimas Alexandre Kliemann, Cristiane Valle Tovo, Ana Beatriz Gorini da Veiga, Angelo Alves de Mattos, Charles Wood
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Gastroenterology & Hepatology
Marcelo Campos Appel-da-Silva, Suelen Aparecida da Silva Miozzo, Isabella de Azevedo Dossin, Cristiane Valle Tovo, Fernanda Branco, Angelo Alves de Mattos
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Infectious Diseases
Luciana Brosina De Leon, Cristiane Valle Tovo, Dimas Alexandre Kliemann, Angelo Alves De Mattos, Alberi Adolfo Feltrin, Liliane Souto Pacheco, Paulo Roberto Lerias De Almeida
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2016)
Letter
Gastroenterology & Hepatology
Angelo Zambam de Mattos, Suelen Aparecida da Silva Miozzo, Cristiane Valle Tovo, Angelo Alves de Mattos
Article
Surgery
Rafael Bergesch D'Incao, Cristiane Valle Tovo, Vanessa Sune Mattevi, Diego Olschowsky Borges, Jane Maria Ulbrich, Gabriela Perdomo Coral, Mauricio Jacques Ramos, Nelson Guardiola Meinhardt
Article
Parasitology
Anelise Fernanda Zanolla, Caroline Buss, Dimas Alexandre Kliemann, Giselle Souza Pinto, Vivian Silveira Vasques, Cristiane Valle Tovo
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2017)
Article
Multidisciplinary Sciences
Dimas Alexandre Kliemann, Cristiane Valle Tovo, Ana Beatriz Gorini da Veiga, Andre Luiz Machado, John West
Review
Gastroenterology & Hepatology
Cristiane V. Tovo, Sabrina A. Fernandes, Caroline Buss, Angelo A. de Mattos
WORLD JOURNAL OF HEPATOLOGY
(2017)
Review
Gastroenterology & Hepatology
Sabrina Alves Fernandes, Angelo Alves de Mattos, Cristiane Valle Tovo, Claudio Augusto Marroni
WORLD JOURNAL OF HEPATOLOGY
(2016)
Article
Infectious Diseases
Adaliany Cecilia da Silva Souza, Giorgia de Souza Marasca, Nelson Alexandre Kretzmann-Filho, Aline Dall-Bello, Dimas Alexandre Kliemann, Cristiane Valle Tovo, Ana Beatriz Gorini da Veiga
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2017)