Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors

Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase

(2015) Joonhyeok Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis

(2014) Chin-Feng Chan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation

(2014) Christopher A. Ramsden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone

(2014) Dennis Falzon et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Diagnosis of Enzyme Inhibition Using Excel Solver: A Combined Dry and Wet Laboratory Exercise

(2014) Albino A. Dias et al.   JOURNAL OF CHEMICAL EDUCATION

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins

(2014) Mor Goldfeder et al.   Nature Communications

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

Potent low toxicity inhibition of human melanogenesis by novel indole-containing octapeptides

(2012) Anan Abu Ubeid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Natural and Synthetic Tyrosinase Inhibitors as Antibrowning Agents: An Update

(2012) M. R. Loizzo et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Novel Tyrosinase Inhibitors From Natural Resources - Their Computational Studies

(2012) M.T.H. Khan   CURRENT MEDICINAL CHEMISTRY

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Large-scale prediction and testing of drug activity on side-effect targets

(2012) Eugen Lounkine et al.   NATURE

Crystal Structure ofAgaricus bisporusMushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone

(2011) Wangsa T. Ismaya et al.   BIOCHEMISTRY

Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase

(2011) Wei Yi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The association between Parkinson's disease and melanoma

(2011) Tianhong Pan et al.   INTERNATIONAL JOURNAL OF CANCER

The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase

(2011) Alexandra D. Ryazanova et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site

(2010) Usman Ghani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of α-MSH-induced melanin production in melanoma B16 cells

(2010) P. Thanigaimalai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

(2010) Michael M. Mysinger et al.   Journal of Chemical Information and Modeling

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

(2010) Ataman Sendoel et al.   NATURE

Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities

(2009) Qin Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Variations in IC50 Values with Purity of Mushroom Tyrosinase

(2009) Elizabeth Neeley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Updated Review of Tyrosinase Inhibitors

(2009) Te-Sheng Chang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Automated Docking Screens: A Feasibility Study

(2009) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds

(2008) Jinbing Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enzyme, Protein, Carbohydrate, and Phenolic Contaminants in Commercial Tyrosinase Preparations: Potential Problems Affecting Tyrosinase Activity and Inhibition Studies

(2008) Allison Flurkey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antithyroid Drug Carbimazole and Its Analogues: Synthesis and Inhibition of Peroxidase-Catalyzed Iodination ofl-Tyrosine

(2008) Debasis Das et al.   JOURNAL OF MEDICINAL CHEMISTRY