Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 4, Pages 8699-8718Publisher
MDPI
DOI: 10.3390/ijms16048699
Keywords
xenobiotic; immune; endocrine; epigenome; gut microbes; oxidative stress; transposable elements; endocrine disruptors; transgenerational; gene environment interactions; seizures; genotype
Funding
- Cyprus Institute of Neurology and Genetics
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Diverse environmental factors have been implicated with the development of autism spectrum disorders (ASD). Genetic factors also underlie the differential vulnerability to environmental risk factors of susceptible individuals. Currently the way in which environmental risk factors interact with genetic factors to increase the incidence of ASD is not well understood. A greater understanding of the metabolic, cellular, and biochemical events involved in gene x environment interactions in ASD would have important implications for the prevention and possible treatment of the disorder. In this review we discuss various established and more alternative processes through which environmental factors implicated in ASD can modulate the genome and epigenome of genetically-susceptible individuals.
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