Journal
ANALYTICAL LETTERS
Volume 41, Issue 3, Pages 456-468Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032710701567055
Keywords
biosensor; hypoxanthine; xanthine oxidase; FeTPP NPs; microdialysis; dissolved oxygen
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The preparation and performance of hypoxanthine (Hx) electrochemical biosensor, which was based on iron (III) meso-tetraphenylporphyrin (FeTPP) nanoparticles (NPs), is reported in this work. FeTPP NPs prepared by mixing solvent techniques with diameters ca. 25 similar to 45nm and were used as a mediator. The XOD/FeTPPNP/GC electrode exhibited good amperometric signal for Hx. Based on the consumption of dissolved oxygen during the oxidation process of Hx catalyzed by the immobilized XOD, the biosensor could detect the concentration of Hx up to 0.34mM with a detection limit of 1.0M. The usefulness of this biosensor for the analysis of real sample was also demonstrated by determining Hx in rat brain dialysate coupled with microdialysis.
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