Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model

Fingolimod Prevents Blood-Brain Barrier Disruption Induced by the Sera from Patients with Multiple Sclerosis

(2015) Hideaki Nishihara et al.   PLoS One

Sera from Remitting and Secondary Progressive Multiple Sclerosis Patients Disrupt the Blood-Brain Barrier

(2014) Fumitaka Shimizu et al.   PLoS One

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS

(2013) Stefan Bittner et al.   NATURE MEDICINE

Mrp1 is Essential for Sphingolipid Signaling to P-Glycoprotein in Mouse Blood–Brain and Blood–Spinal Cord Barriers

(2012) Tara A Cartwright et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Fingolimod-associated macular edema: Incidence, detection, and management

(2012) N. Jain et al.   NEUROLOGY

Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists

(2011) Martine Tencé et al.   CELLULAR SIGNALLING

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

(2009) Alan S. Fanning et al.   Annals of the New York Academy of Sciences

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation

(2009) Caroline Zeiller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

(2009) David Marsolais et al.   NATURE REVIEWS DRUG DISCOVERY

FTY720 inhibits S1P-mediated endothelial healing: Relationship to S1P1-receptor surface expression

(2008) Vera Krump-Konvalinkova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage

(2008) Carolyn A. Foster et al.   BRAIN PATHOLOGY

Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate

(2008) Sven-Christian Sensken et al.   CELLULAR SIGNALLING

Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells

(2008) Mohammad Tauseef et al.   CIRCULATION RESEARCH

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Regulation of vascular permeability by sphingosine 1-phosphate

(2008) Lichun Wang et al.   MICROVASCULAR RESEARCH

Pericyte–endothelial cell interaction increases MMP-9 secretion at the blood–brain barrier in vitro

(2007) Alla Zozulya et al.   BRAIN RESEARCH