Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 11, Pages 27978-27987Publisher
MDPI AG
DOI: 10.3390/ijms161126071
Keywords
Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity
Funding
- Natural Science Foundation Committee of China [81160496]
- Science and Technology Fund of Guizhou Province [[2009]2145]
- Research Grants Council of the Hong Kong Special Administrative Region, China [HKBU 262912, HKBU12103014]
- HKBU Interdisciplinary Research Matching Scheme [RC-IRMS/12-13/03]
- Faculty Research Grants, Hong Kong Baptist University [FRG2/14-15/047, FRG1/13-14/029]
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Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 mu M (SI = 12.2).
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