Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms17010052
Keywords
PERK; IRE1; ATF6 alpha; Grp78; cardiac ion channels; ischemia
Funding
- National Institutes of Health (NIH) Grants [RO1 HL104025, HL106592]
- Veterans Affairs MERIT grant [BX000859]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL106592, R01HL104025] Funding Source: NIH RePORTER
- Veterans Affairs [I01BX000859] Funding Source: NIH RePORTER
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The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.
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